The Tumour Microenvironment Causes and Consequences of Hypoxia and Acidity

by Goode, Jamie A.; Chadwick, Derek J.

• ISBN13: 9780471499596
• ISBN10: 0471499595
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-11-28
• Publisher: WILEY

Summary

Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, "in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.

Author Biography

Jamie Goode is a British author with a PhD in plant biology, and a wine columnist of The Sunday Express. Goode also contributes to wine publications such as Harpers, The World of Fine Wine, Decanter, GrapesTALK and Sommelier Journal.

Derek J. Chadwick is the editor of The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity, published by Wiley.

Table of Contents

Introduction	1	(6)
Robert J. Gillies
Frontiers in the measurement of cell and tissue pH	7	(16)
Robert J. Gillies
Ronald M. Lynch
Discussion	19	(4)
The physiological environment in cancer vascularization, invasion and metastasis	23	(23)
Zaver M. Bhujwalla
Dmitri Artemov
Eric Aboagye
Ellen Ackerstaff
Robert J. Gillies
Kshama Natarajan
Meiyappan Solaiyappan
Discussion	38	(8)
Why are cancers acidic? A carrier-mediated diffusion model for H+ transport in the interstitial fluid	46	(22)
J.R. Griffiths
D.J.O. McIntyre
F.A. Howe
M. Stubbs
Discussion	62	(6)
pH and therapy of human cancers	68	(17)
Jeffrey L. Evelhoch
Discussion	80	(5)
Mathematical models of tumour invasion mediated by transformation-induced alteration of microenvironmental pH	85	(15)
Robert A. Gatenby
Edward T. Gawlinski
Discussion	96	(4)
pH regulation of renal gene expression	100	(15)
Norman P. Curthoys
Aimin Tang
Gerhard Gstraunthaler
Discussion	111	(4)
Genetic determinants that influence hypoxia-induced apoptosis	115	(18)
Rodolfo M. Alarcon
Nicholas C. Denko
Amato J. Giaccia
Discussion	128	(5)
Genomic instability in cancer	133	(19)
Sara Rockwell
Jianling Yuan
Shani Peretz
Peter M. Glazer
Discussion	142	(10)
General discussion I	152	(113)
pH, hypoxia and metastasis	154	(15)
R. P. Hill
K. De Jaeger
A. Jang
R. Cairns
Discussion	165	(4)
Modelling tumour acidity and invasion	169	(17)
Steven D. Webb
Jonathan A. Sherratt
Reginald G. Fish
Discussion	181	(5)
pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth	186	(13)
Jacques Pouyssegur
Arlette Franchi
Gilles Pages
Discussion	196	(3)
pH and chemotherapy	199	(13)
Natarajan Raghunand
Robert J. Gillies
The HIF pathway: implications for patterns of gene expression in cancer	212	(20)
Charles C. Wykoff
Christopher W. Pugh
Adrian L. Harris
Patrick H. Maxwell
Peter J. Ratcliffe
Discussion	225	(7)
pH and multidrug resistance	232	(19)
Paul D. Roepe
Discussion	247	(4)
`The metabolism of tumours': 70 years later	251	(14)
Gregg L. Semenza
Dmitri Artemov
Atul Bedi
Zaver Bhujwalla
Kelly Chiles
David Feldser
Erik Laughner
Rajani Ravi
Jonathan Simons
Panthea Taghavi
Hua Zhong
Discussion	260	(5)
General discussion II Tissue penetration	265	(27)
The multiple mechanisms of multidrug resistance and cellular pH	269	(21)
Sanford Simon
Discussion	282	(8)
Summing up	290	(2)
Robert J. Gillies
Index of contributors	292	(2)
Subject index	294