Ultrastructure of Mast Cells And Basophils

by Dvorak, Ann M.

• ISBN13: 9783805578646
• ISBN10: 3805578644
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-06-01
• Publisher: KARGER, S. PUBLISHERS INC

Summary

In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. Including more than 180 excellent micrographs, this book will be of interest to basic scientists in immunology, cell biology, secretion and angiogenesis research, and histochemistry. As mast cells and basophils play a crucial role in various diseases, it will be essential reading for allergists, immunologists, dermatologists, hematologists, gastroenterologists, rheumatologists, neurologists, pathologists, pulmonologists, and cardiologists.

Table of Contents

Introduction	p. 1
Ultrastructural analysis is necessary and sufficient for identification of basophils and mast cells	p. 10
Cyclooxygenase, a key enzyme family for production of prostaglandins, is present in human mast cell lipid bodies	p. 68
Subcellular localization of the cytokines, basic fibroblast growth factor and tumor necrosis factor-[alpha] in mast cells	p. 72
Immunogold ultrastructural techniques identify subcellular sites of cymase, Charcot-Leyden crystal protein, and histamine in basophils and mast cells	p. 89
Ultrastructural enzyme-affinity-gold and inhibitor-gold techniques identify subcellular sites of histamine and heparin in basophils and mast cells	p. 98
Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents	p. 135
Mast cell-derived mediators of enhanced microvascular permeability, vascular permeability factor/vascular endothelial growth factor, histamine, and serotonin, cause leakage of macromolecules through a new endothelial cell permeability organelle, the vesiculo-vacuolar organelle	p. 185
Degranulation and recovery form degranulation of basophils and mast cells	p. 205
Mast cell secretory granules and lipid bodies contain the necessary machinery important for the in situ synthesis of proteins	p. 252
Concluding statement	p. 316
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