Understanding and Modulating Aging, Volume 1067

by Rattan, Suresh I. S.; Kristensen, Peter; Clark, Brian F. C.

• ISBN13: 9781573315999
• ISBN10: 1573315990
• Edition: 1st
• Format: Paperback
• Copyright: 2006-07-12
• Publisher: Wiley-Blackwell

Summary

For the last 40 years, biogerontology-the study of the biological basis of aging-has progressed tremendously, and it has now become an independent and respected field of study and research. This volume brings together contributions by biogerontologists, bioethicists, biodemographers, researchers, students, clinicians, and dieticians.The main areas of discussion and presentation of new research results include (1) biological and non-biological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifespan and health-span extension; (3) physiological, cellular, and molecular aspects of aging; (4) new technologies to understand and modulate aging; (5) the latest successful approaches in the prevention and treatment of age-related diseases, and (6) aging intervention, prevention, and modulation by genes, natural and synthetic molecules, and lifestyle modifications.Accordingly, the main sections of the volume focus on the following topics: defining aging, longevity, and the diseases of aging; selected aging organs; cellular aging; molecular aging; ethics of aging intervention; genetics of aging and longevity; and aging interventions.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Suresh Rattan is a biogerontologist - a researcher in the field of biology of ageing, biogerontology. Peter Kristensen is the editor of Understanding and Modulating Aging, Volume 1067, published by Wiley.

Table of Contents

Preface.
By SURESH I.S. RATTAN, PETER KRISTENSEN, AND BRIAN F.C. CLARK	XV
Part I. Aging: Ideas and Challenges
Aging is No Longer an Unsolved Problem in Biology.
By ROBIN HOLLIDAY	1	(9)
Free Radical Theory of Aging: An Update.
By DENHAM HARMAN	10	(12)
The Free Radical Fantasy.
By RANDOLPH M. HOWES	22	(5)
Catabolic Insufficiency and Aging.
By ALEXEI TERMAN	27	(10)
Methionine Sulfoxide Reductases.
By FILIPE CABREIRO, CÉDRIC R. PICOT, BERTRAND FRIGUET, AND ISABELLE PETROPOULOS	37	(8)
Inadequate Intensity of Various Components of Total Environmental Signals Can Lead to Natural Aging.
By ALEXANDER V. KHALYAVKIN AND ANATOLI I. YASHIN	45	(2)
Cellular Redox Regulation and Prooxidant Signaling Systems.
By ANTHONY W. LINNANE AND HAYDEN EASTWOOD	47	(9)
Human Immunosenescence.
By G. PAWELEC, S. KOCH, C. FRANCESCHI, AND A. WIKBY	56	(10)
Aging in Mouse and Human Systems.
By LLOYD DEMETRIUS	66	(17)
Extrapolaholics Anonymous.
By AUBREY D.N.J. DE GREY	83	(11)
The Value of Life and the Value of Life Extension.
By STEVEN HORROBIN	94	(12)
Part II. Aging Organisms, Organs, and Tissues
OXPHOS Supercomplexes.
By FRANK KRAUSE, CHRISTIAN Q. SCHECKHUBER, ALEXANDRA WERNER, SASCHA REXROTH, NICOLE H. REIFSCHNEIDER, NORBERT A. DENCHER, AND HEINZ D. OSIEWACZ	106	(10)
Unraveling Age-Dependent Variation of the Mitochondrial Proteome.
By NORBERT A. DENCHER, SATARO GOTO, NICOLE H. REIFSCHNEIDER, MICHIRU SUGAWA, AND FRANK KRAUSE	116	(4)
Using Caenorhabditis elegans as a Model for Aging and Age-Related Diseases.
By ANDERS OLSEN, MAITHILI C. VANTIPALLI, AND GORDON J. LITHGOW	120	(9)
Age-Dependent Decrease in Renal Glucocorticoid Receptor Function Is Reversed By Dietary Restriction in Mice.
By RAMESH SHARMA AND DEBIPREETA DUTTA	129	(13)
Investigation of Differentially Expressed Genes in the Ventricular Myocardium of Senescent Rats.
By AKIRA ISHIHATA AND YUMI KATANO	142	(10)
Naive T Cells in the Elderly.
By GERALD PFISTER, DANIELA WEISKOPF, LUTFAN LAZUARDI, RANIA D. KOVAIOU, DANIEL P. CIOCA, MICHAEL KELLER, BERND LORBEG, WALTHER PARSON, AND BEATRIX GRUBECK-LOEBENSTEIN	152	(6)
Brain Lipopigment Accumulation in Normal and Pathological Aging.
By DAN RIGA, SORIN RIGA, FLORIN HALALAU, AND FRANCISC SCHNEIDER	158	(6)
Aging and Orchidectomy Modulate Expression of VEGF Receptors (Flt-1 and Flk-1) on Corpus Cavernosum of the Rat.
By DELMINDA NEVES, JANETE SANTOS, NUNO TOMADA, HENRIQUE ALMEIDA, AND PEDRO VENDEIRA	164	(9)
Role of Angiotensin II and Endothelin-1 Receptors in Aging-Related Functional Changes in Rat Cardiovascular System.
By AKIRA ISHIHATA AND YUMI KATANO	173	(9)
Part III. Aging Cells, Organelles, and Macromolecules Mitochondria Damage Checkpoint, Aging, and Cancer.
By KESHAV K. SINGH	182	(9)
DNA Damage By Free Radical Production By Aminoguanidine.
By GEORGE SUJI AND SUBRAMANIUM SIVAKAMI	191	(9)
Effect of Lipid Restriction on Mitochondrial Free Radical Production and Oxidative DNA Damage.
By ALBERTO SANZ, PILAR CARO, JOSE GOMEZ SANCHEZ, AND GUSTAVO BARJA	200	(10)
Establishment of H2O2-Induced Premature Senescence in Human Fibroblasts Concomitant with Increased Cellular Production.
By STEPHANIE ZDANOV, JOSE REMACLE, AND OLIVIER TOUSSAINT	210	(7)
CARF Regulates p19ARF-p53-p21WAF1 Senescence Pathway By Multiple Checkpoints.
By SUNIL C. KAUL, KAMRUL HASAN, AND RENU WADHWA	217	(3)
Structural and Functional Differences between Mouse Mot-1 and Mot-2 Proteins That Differ in Two Amino Acids.
By CUSTER C. DEOCARTS, KAZUHIKO YAMASAKI, SUNIL C. KAUL, AND RENU WADHWA	220	(4)
Proteasomal Oscillation during Mild Heat Shock in Aging Human Skin Fibroblasts.
By DAVID CHRISTIAN KRAFT, CUSTER C. DEOCARIS, AND SURESH I.S. RATTAN	224	(4)
Apoptosis and Necrosis in Senescent Human Fibroblasts.
By SUSUMU OHSHIMA	228	(7)
Aging of Murine Mesenchymal Stem Cells.
By CHRISTINE FEHRER, GERHARD LASCHOBER, AND GÜNTER LEPPERDINGER	235	(8)
Prevention of Accelerated Cell Aging in the Werner Syndrome.
By TERENCE DAVIS, MICHÈLE F. HAUGHTON, CHRISTOPHER J. JONES, AND DAVID KIPLING	243	(5)
Oxidative Stress Induces Intralysosomal Accumulation of Alzheimer Amyloid β-Protein in Cultured Neuroblastoma Cells.
By LIN ZHENG, KARIN ROBERG, FREDRIK JERHAMMAR, JAN MARCUSSON, AND ALEXEI TERMAN	248	(4)
Part IV. Gerontogenesis and Longevity Assurance
The Genetics of Human Longevity.
By MIRIAM CAPRI, STEFANO SALVIOLI, FEDERICA SEVINI, SILVANA VALENSIN, LAURA CELANI, DANIELA MONTI, GRAHAM PAWELEC, GIOVANNA DE BENEDICTIS, EFSTATHIOS S. GONOS, AND CLAUDIO FRANCESCHI	252	(12)
Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis.
By GIUST IRMA FORTE, PAOLO RAGONESE, GIUSEPPE SALEMI, LETIZIA SCOLA, GIUSEPPINA CANDORE, MARCO D'AMELIO, ANTONIO CRIVELLO, NORMA DI BENEDETTO, DOMENICO NUZZO, ANTONIO GIACALONE, DOMENICO LIO, AND CALOGERO CARUSO	264	(6)
Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity.
By GIUSEPPINA CANDORE, CARMELA RITA BALISTRERI, MARIA PAOLA GRIMALDI, FLORINDA LISTI, SONYA VASTO, MARCO CARUSO, GREGORIO CAIMI, ENRICO HOFFMANN, GIUSEPPINA COLONNA-ROMANO, DOMENICO LIO, GIUSEPPE PAOLISSO, CLAUDIO FRANCESCHI, AND CALOGERO CARUSO	270	(6)
Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily.
By CARMELA RITA BALISTRERI, SONYA VASTO, FLORINDA LISTI, MARIA PAOLA GRIMALDI, DOMENICO LIO, GIUSEPPINA COLONNA-ROMANO, MARCO CARUSO, GREGORIO CAIMI, ENRICO HOFFMANN, CALOGERO CARUSO, AND GIUSEPPINA CANDORE	276	(6)
Inflammation, Longevity, and Cardiovascular Diseases.
By GIUSEPPINA CANDORE, ALESSANDRA AQUINO, CARMELA RITA BALISTRERI, MATTEO BULATI, DANIELE DI CARLO, MARIA PAOLA GRIMALDI, FLORINDA LISTI, VALENTINA ORLANDO, SONYA VASTO, MARCO CARUSO, GIUSEPPINA COLONNA-ROMANO, DOMENICO LIO, AND CALOGERO CARUSO	282	(6)
Frequency of Polymorphisms of Signal Peptide of TGF-β1 and –1082G/A SNP at the Promoter Region of I1-10 Gene in Patients with Carotid Stenosis.
By ANTONIO CRIVELLO, ANTONIO GIACALONE, LETIZIA SCOLA, GIUSI IRMA FORTE, DOMENICO NUZZO, ROBERTINA GIACCONI, CATIA CIPRIANO, GIUSEPPINA CANDORE, EUGENIO MOCCHEGIANI, GIUSEPPINA COLONNA ROMANO, DOMENICO LIO, AND CALOGERO CARUSO	288	(6)
Reduced Expression Levels of the Senescence Biomarker Clüsterin/Apolipoprotein J in Lymphocytes from Healthy Centenarians.
By IOANNIS P. TROUGAKOS, CHARIKLLA PETROPOULOU, CLAUDIO FRANCESCHI, AND EFSTATHIOS S. GONGS	294	(7)
Heat-Shock Protein 70 Genes and Human Longevity.
By RIPUDAMAN SINGH, STEEN KØLVRAA, PETER BROSS, KAARE CHRISTENSEN, NIELS GREGERSEN, QILIDA TAN, LIFFE BIRK JENSEN, HANS EIBERG, AND SURESH I.S. RATTAN	301	(8)
Possible Associations between Successful Aging and Polymorphic Markers in the Werner Gene Region.
By MARI SILD, CEMILE KOCA, METTE H. BENDIXEN, HENRIK FREDERIKSEN, MATT MCGUE, STEEN KØLVRAA, KAARE CHRISTENSEN, AND BJØRN NEXØ	309	(2)
The Pattern of Chromosome-Specific Variations in Telomere Length in Humans Shows Signs of Heritability and Is Maintained through Life.
By J. GRAAKJAER, J.A. LONDONO-VALLEJO, K. CHRISTENSEN, AND S. KØLVRAA	311	(6)
Identification of Genes Involved in Healthy Aging and Longevity.
By JENS WEIBEL, MORTEN DRÆBY SØRENSEN, AND PETER KRISTENSEN	317	(6)
Part V. Interventions, Preventions, and Therapies
Prevention and Treatment of Skin Aging.
By JERRY L. MCCULLOUGH AND KRISTEN M. KELLY	323	(9)
Kinetin-Induced Differentiation of Normal Human Keratinocytes Undergoing Aging in Vitro.
By ULRICH BERGE, PETER KRISTENSEN, AND SURESH I.S. RATTAN	332	(5)
Epidermal and Dermal Characteristics in Skin Equivalent after Systemic and Topical Application of Skin Care Ingredients.
By JANA VICANOVA, CHARBEL BOUEZ, SOPHIE LACROIX, LARS LINDMARK, AND ODILF DAMOUR	337	(6)
MAP Kinases and Heat Shock–Induced Hormesis in Human Fibroblasts during Serial Passaging in Vitro.
By ELISE R. NIELSEN, YVONNE E.G. ESKILDSEN-HELMOND, AND SURESH I.S. RATTAN	343	(6)
The Roles of Satellite Cells and Hematopoietic Stern Cells in Impaired Regeneration of Skeletal Muscle in Old Rats.
By SHUICHI MACHIDA AND MITSUO NARUSAWA	349	(5)
Age-Related Effects of Dexamethasone Administration in Adrenal Zona Reticularis.
By HENRIQUE ALMEIDA, LILIANA MATOS, JORGE FERREIRA, AND DELMINDA NEVES	354	(7)
Does Chronic Glycolysis Accelerate Aging? Could This Explain How Dietary Restriction Works?
By ALAN R. HIPKISS	361	(8)
Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?
By ALAN R. HIPKISS	369	(6)
The Necessity of Having a Proper Dose of (—)Deprenyl (D) to Prolong the Life Spans of Rats Explains Discrepancies among Different Studies in the Past.
By KENICHI KITANI, SETSUKO KANAI, KYOKO MIYASAKA, MARIA CRISTINA CARRILLO, AND GWEN O. IVY	375	(8)
Processing, Lysis, and Elimination of Brain Lipopigments in Rejuvenation Therapies.
By SORIN RIGA, DAN RIGA, FRANCISC SCHNEIDER, AND FLORIN HALALAU	383	(5)
Effect of Dietary Restriction on Learning and Memory Impairment and Histologic Alterations of Brain Stem in Senescence-Accelerated Mouse (Sam) P8 Strain.
By RYOYA TAKAHASHI, YUKARI KOMIYA, AND SATARO GOTO	388	(6)
Curcumin's Biphasic Hormetic Response on Proteasome Activity and Heat-Shock Protein Synthesis in Human Keratinocytes.
By REHAB E. ALI AND SURESH I.S. RATTAN	394	(6)
Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype.
By FRANCESO MAROTTA, MARK WEKSLER, YASUHIRO NAITO, CHISATO YOSHIDA, MAYUMI YOSHIOKA, AND PAOLO MARANDOLAE	400	(8)
Redox Status Impairment in Liver and Kidney of Prematurely Senescent Mice.
By F. MAROTTA, F. LORENZETTI, M. HARADA, S.K. ONO-NITA, E. MINELLI, AND P. MARANDOLA	408	(6)
A Dietary Supplement Improves Outcome in an Experimental Influenza Model in Old Mice.
By J. CERVI, F. MAROTTA, C. BATER, K. MASULAIR, E. MINELLI, M. HARADA, AND P. MARANDOLA	414	(6)
Preincubation with the Proteasome Inhibitor MG-132 Enhances Proteasome Activity via the Nrf2 Transcription Factor in Aging Human Skin Fibroblasts.
By DAVID CHRISTIAN KRAFT, CUSTER C. DEOCARIS, RENU WADHWA, AND SURESH I.S. RATTAN	420	(5)
Exercise and Hormesis.
BY LI LI JI, MARIA-CARMEN GOMEZ-CABRERA, AND JOSE VINA	425	(11)
Part VI. Novel Technologies, Strategies, and Possibilities
Stem Cells.
By MOUSTAPHA KASSEM	436	(7)
Heat Shock—Induced Enhancement of Osteoblastic Differentiation of hTERT-Immortalized Mesenchymal Stem Cells.
By RUNE NØRGAARD, MOUSTAPHA KASSEM, AND SURESH I.S. RATTAN	443	(5)
Selective PPAR Agonists for the Treatment of Type 2 Diabetes.
By JAN O. NEHLIN, JOHN P. MOGENSEN, INGRID PETTERSON, LONE JEPPESEN, JAN FLECKNER, ERIK M. WULFF, AND PER SAUERBERG	448	(6)
Alzheimer's Disease Pathogenesis.
By DENHAM HARMAN	454	(7)
RNA Regulation in Mammals.
By MACIEJ SZYMANSKI AND JAN BARCISZEWSKI	461	(8)
Quantum Dot-Based Protein Imaging and Functional Significance of Two Mitochondrial Chaperones in Cellular Senescence and Carcinogenesis.
By ZEENIA KAUL, TOMOKO YAGUCHI, SUNIL C. KAUL, AND RENU WADHWA	469	(5)
Phage-Displayed Antibodies for the Detection of Glycated Proteasome in Aging Cells.
By REGINA GONZALEZ-DOSAL, MORTEN DRÆBY SØRENSEN, BRIAN F.C. CLARK, SURESH I.S. RATTAN, AND PETER KRISTENSEN	474	(5)
Techniques Used in Studies of Age-Related DNA Methylation Changes.
By TOMASZ K. WOJDACZ AND LISE LOTTE HANSEN	479	(9)
Geroprotection By Glycerol.
By CUSTER C. DEOCARIS, BHUPAL G. SHRESTHA, DAVID C. KRAFT, KAZUHIKO YAMASAKI, SUNIL C. KAUL, SURESH S. RATTAN, AND RENU WADHWA	488	(5)
Age-Dependent Effects of in Vitro Radiofrequency Exposure (Mobile Phone) on CD95+ T Helper Human Lymphocytes.
By MIRIAM CAPRI, STEFANO SALVIOLI, SERENA ALTILIA, FEDERICA SEVINI, DANIEL REMONDINI, PIETRO MESIRCA, FERDINANDO BERSANI, DANIELA MONTI, AND CLAUDIO FRANCESCHI	493	(7)
Severe Acute Respiratory Syndrome (SARS).
By MORTEN DRÆBY SØRENSEN, BRIAN SØRENSEN, REGINA GONZALEZ-DOSAL, CONNIE JENNING MELCHJORSEN, JENS WETBEL, JING WANG, CIIEN WIE JUN, YANG HUANMING, AND PETER KRISTENSEN	500	(7)
Index of Contributors	507