Unraveling the Genetics of Bovine Johne's Disease

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  • Edition: 1st
  • Format: Paperback
  • Copyright: 2011-03-30
  • Publisher: Nova Science Pub Inc
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Johne's disease is a chronic, granulomatous enteritis of ruminants and some wild-type species that is caused by infection with Mycobacterium avium spp. paratuberculosis (MAP). This inflammatory bowel disease (IBD) is characterised by a lengthy yet variable asymptomatic subclinical phase in which infected animals can transmit MAP to their progeny and herd mates; this is followed by a clinical phase characterised by chronic diarrhoea, wasting, and eventually death. The impact of Johne's disease is particularly evident in the dairy and beef industries, where significant losses due to reduced productivity and fertility, mortality, and premature culling have been reported. This book addresses the genetics of this condition and its possible treatments.

Table of Contents

MAP & the Bovine Immune Response
A Role for CD8+ & ?d-T Cells in Early Infection
The Host Response during the sub-clinical phase of infection
Clinical phase
Pathological similarities between Johne's disease & Crohn's disease
A genetic basis for mammalian IBDs
Potential susceptibility loci conserved across mammalian IBDs
Impact of alternate mechanisms of gene regulation
Table of Contents provided by Publisher. All Rights Reserved.

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