Vaccine Adjuvants and Delivery Systems

by Singh, Manmohan

• ISBN13: 9780471739074
• ISBN10: 0471739073
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-06-29
• Publisher: Wiley-Interscience

Summary

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: Provides a comprehensive overview of the rapidly evolving field and developing formulation methods Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

Author Biography

MANMOHAN SINGH, M.Pharm., PhD, has worked in the area of vaccine adjuvants and delivery systems for seventeen years and has authored over eighty-five manuscripts and review articles. Dr. Singh is on the editorial board of five international journals and has contributed several book chapters. He is a Director of Vaccine Research within Novartis Vaccines.

Table of Contents

Contributors	p. vii
Preface	p. ix
Development of Vaccine Adjuvants: A Historical Perspective	p. 1
Antigen Processing and Presentation	p. 33
Mechanisms of Adjuvant Action	p. 53
Aluminum-Containing Adjuvants: Properties, Formulation, and Use	p. 81
MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant	p. 115
TLR4 Agonists as Vaccine Adjuvants	p. 131
Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants	p. 157
Small Molecule Immunopotentiators as Vaccine Adjuvants	p. 175
New ISCOMs Meet Unsettled Vaccine Demands	p. 191
Surface-Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems	p. 223
Liposomal Cytokines and Liposomes Targeted to Co-Stimulatory Molecules as Adjuvants for HIV Subunit Vaccines	p. 249
Archaeosome Vaccine Adjuvants for Cross-Priming CD8[superscript +] T-Cell Immunity	p. 263
Mucosal Adjuvants and Delivery Systems	p. 295
Cytokines as Vaccine Adjuvants	p. 327
Polyphosphazenes as Vaccine Adjuvants	p. 355
Vaccine Delivery by Transdermal Electroporation	p. 379
Nonclinical Safety Assessment of Vaccines and the Evaluation of Novel Adjuvants and Delivery Systems	p. 403
Safety Evaluation of Vaccine Adjuvants	p. 421
Index	p. 445
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