Vander's Renal Physiology, 7th Edition

by Eaton, Douglas; Pooler, John

• ISBN13: 9780071613033
• ISBN10: 007161303X
• Edition: 7th
• Format: Paperback
• Copyright: 2009-03-30
• Publisher: McGraw-Hill Medical

Summary

The structure, function, and pathologies of the human kidney - simplified and explained ..Written in a concise, conversational style this trusted text reviews the fundamental principles of renal physiology that are essential for an understanding of clinical medicine. Combining the latest research with a fully integrated teaching approach,Vander's Renal Physiology ...Features: . Offers the best review of renal physiology available for the USMLE Step 1. Begins with the basics and works up to advanced principles. Distills the essence of renal processes and their regulation in a concise, integrated manner that focuses on the logic of renal processes. Features learning aids such as flow charts, diagrams, key concepts, clinical examples, learning objectives, and review questions with answers and explanations. Explains the relationship between blood pressure and renal function. Presents the normal functions of the kidney with clinical correlations to disease states. Includes the most current research on the molecular and genetic principles underlying renal physiology .

Author Biography

Douglas C. Eaton, PhD is a Professor of Physiology and Pediatrics at Emory University in the School of Medicine, Atlanta, Georgia.
.John P. Pooler, PhD is an Associate Professor of Physiology at Emory University in the School of Medicine, Atlanta, Georgia.

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Table of Contents

Preface	p. vii
Renal Functions, Anatomy, and Basic Processes	p. 1
Functions	p. 2
Anatomy of the Kidneys and Urinary System	p. 4
The Nephron	p. 5
Blood Supply to the Nephrons	p. 12
Basic Renal Processes	p. 16
Renal Blood Flow and Glomerular Filtration	p. 24
Glomerular Filtration and Renal Blood Flow	p. 25
Flow, Resistance, and Pressure in the Kidneys	p. 25
Glomerular Filtration	p. 26
Autoregulation	p. 34
Clearance	p. 38
Clearance Units	p. 39
Plasma Creatinine and Urea Concentrations as Indicators of GFR Changes	p. 43
Basic Transport Mechanisms	p. 47
Crossing the Epithelial Barriers	p. 47
Receptor-Mediated Endocytosis and Transcytosis	p. 53
Transport Mechanisms in Reabsorption	p. 55
Renal Handling of Organic Substances	p. 63
Active Proximal Reabsorption of Organic Nutrients (eg, Glucose, Amino Acids)	p. 64
Proteins and Peptides	p. 66
Active Proximal Secretion of Organic Anions	p. 68
Active Proximal Secretion of Organic Cations	p. 70
pH Dependence of Passive Reabsorption or Secretion	p. 74
Urea	p. 74
Basic Renal Processes for Sodium, Chloride, and Water	p. 77
Overview	p. 78
Individual Tubular Segments	p. 84
Urinary Concentration: The Medullary Osmotic Gradient	p. 93
Control of Sodium and Water Excretion: Regulation of Plasma Volume and Plasma Osmolality and Renal Control of Systemic Blood Pressure	p. 102
Regulation of Blood Pressure	p. 104
Contribution of the Kidney to the Regulation of Sodium Excretion and Blood Pressure	p. 110
Control of Water Excretion	p. 131
Renal Regulation of Potassium Balance	p. 140
Regulation of Potassium Between the Intracellular and Extracellular Compartments	p. 141
Renal Potassium Handling	p. 143
Regulation of Hydrogen Ion Balance	p. 155
Guidelines for Studying Acid-Base Biology	p. 156
Renal Handling of Acids and Bases	p. 162
Renal Excretion of Acid and Base	p. 165
Hydrogen Ion Excretion on Urinary Buffers	p. 167
Phosphate and Organic Acids as Buffers	p. 169
Hydrogen Ion Excretion on Ammonium	p. 170
Quantification of Renal Acid-Base Excretion	p. 174
Regulation of the Renal Handling of Acids and Bases	p. 176
Control of Renal Glutamine Metabolism and NH4+ Excretion	p. 177
Intravenous Solutions: Lactated Ringer's	p. 178
Specific Categories of Acid-Base Disorders	p. 179
Renal Response to Metabolic Acidosis and Alkalosis	p. 180
Factors Causing the Kidneys to Generate or Maintain A Metabolic Alkalosis	p. 181
Regulation of Calcium and Phosphate Balance	p. 185
Effector Sites for Calcium Balance	p. 188
Hormonal Control of Effector Sites	p. 192
PTH	p. 193
Overview of Renal Phosphate Handling	p. 197
Answers to Study Questions	p. 201
	p. 209
	p. 211
Index	p. 213
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