Vascular Complications of Diabetes: Current Issues in Pathogenesis and Treatment, 2nd Edition

by Editor: Richard Donnelly (University of Nottingham, Nottingham, UK); Editor: Edward Horton (Joslin Diabetes Center, Boston, MA, USA)

• ISBN13: 9781405127851
• ISBN10: 1405127856
• Edition: 2nd
• Format: Paperback
• Copyright: 2005-06-01
• Publisher: Wiley-Blackwell

Summary

-Provides an overview of the clinical features and evidence-based therapies for microvascular and macrovascular disease in diabetes -Provides detailed reviews of diabetic neuropathy and retinpathy, with emphasis on diagnosis and treatment -Provides a description of the biochemical pathways involved in hyperglycaemia-induced structural and functional vascular abnormalities, in particular PKC as a new therapeutic target for delaying and reversing important pathological changes in neural, retinal, renal and endothelial tissues.

Author Biography

Richard Donnelly MD PhD FRCP FRACP is Professor of Vascular Medicine at the University of Nottingham and Honorary Consultant Physician at the J. O'Neil Diabetic Centre, Derbyshire Royal Infirmary, Derby, UK

Table of Contents

List of contributors	v
Preface	vi
SECTION I MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES
The public health impact of the diabetes epidemic	3	(10)
Adrian R. Scott
Risk factors	13	(10)
Adrian R. Scott
Diabetic nephropathy	23	(12)
Adrian R. Scott
Coronary heart disease and diabetes	35	(10)
Adrian R. Scott
Diabetes and cerebrovascular disease	45	(6)
Adrian R. Scott
Erectile dysfunction	51	(8)
Adrian R. Scott
Evidence-based interventions to prevent or retard vascular complications	59	(20)
Adrian R. Scott
SECTION II DIABETIC NEUROPATHIES
Classification and clinical features of neuropathy	79	(6)
Rayaz A. Malik
Pathophysiology of diabetic neuropathy	85	(6)
Rayaz A. Malik
Epidemiology and natural history of DPN	91	(6)
Rayaz A. Malik
Detection/Screening/Assessment	97	(8)
Rayaz A. Malik
Foot ulceration and Charcot arthropathy	105	(8)
Rayaz A. Malik
Treatments options	113	(8)
Rayaz A. Malik
Management guidelines for diabetic peripheral neuropathy and foot ulceration	121	(8)
Rayaz A. Malik
SECTION III DIABETIC RETINOPATHY AND ASSOCIATED OPHTHALMIC DISORDERS
Diabetic retinopathy: epidemiology and risk factors	129	(10)
Hean-Choon Chen
Classification and diagnosis of diabetic retinopathy	139	(12)
Hean-Choon Chen
Diabetic maculopathy	151	(12)
Hean-Choon Chen
Proliferative diabetic retinopathy	163	(8)
Hean-Choon Chen
Non-retinal diabetic ocular complications	171	(8)
Hean-Choon Chen
SECTION IV MECHANISMS OF HYPERGLYCAEMIA INDUCED VASCULAR DYSFUNCTION
Pathophysiology and potential targets for therapeutic intervention	179	(10)
Richard Donnelly
Protein kinase C	189	(8)
Richard Donnelly
Protein kinase C activation and vascular permeability	197	(8)
Richard Donnelly
Role of protein kinase C activation in cardiovascular and renal complications of diabetes	205	(8)
Richard Donnelly
Experimental pharmacology using isoform-selective protein kinase C inhibitors	213	(8)
Richard Donnelly
Clinical trials with ruboxistaurin	221	(5)
Richard Donnelly
Index	226