Vascular Dementia

by Paul, Robert H.; Cohen, Ronald; Ott, Brian R., M.D.; Salloway, Stephen, M.D.

• ISBN13: 9781588293664
• ISBN10: 1588293661
• Format: Hardcover
• Copyright: 2004-12-30
• Publisher: Humana Pr Inc

Summary

A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

Author Biography

Mark S. Aloia, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Clive Ballard: Wolfson Research Centre, University of Newcastle upon Tyne, Newcastle, UK Patricia A. Boyle, PhD: Department of Neurology, Boston University School of Medicine, Boston, MA Adam M. Brickman, MPhil: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Jeffrey Browndyke, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Deborah Cahn-Weiner, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Ronald Cohen, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Anelyssa D'Abreu, MD: Department of Clinical Neurosciences, Brown Medical School, Providence, RI Jennifer Duncan Davis, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sophie Desbiens, BS: Department of Biomedical Engineering, Boston University, MA John E. Donahue, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI Timo Erkinjuntti, MD: Memory Research Unit, Department of Neurology, Helsinki University Central Hospital, Finland Margaret M. Esiri, MD: Department of Clinical Neurology, University of Oxford; Department of Neuropathology, Oxford Radcliffe NHS Trust, UK Marc Fisher, MD: Department of Neurology, University of Massachusetts Medical School, Worcester Kelly D. Garrett, PhD: Utah State University, Logan Serge Gauthier, MD: MCSA Alzheimer's Disease Research Unity, McGill Center for Studies on Aging, McGill University, Montreal, Canada Paula Grammas, PhD: Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City John Gunstad, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Vladimir Hachinski, MD, FRCP(C), DSC: Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada Ebrahim Haroon, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Angela Lee Jefferson, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Kurt A. Jellinger, MD: Institute of Clinical Neurobiology and University of Vienna, Austria Elizabeth M. Jonak, PhD: Yerkes National Primate Center, Emory University, Atlanta, GA Raj Kalaria: Wolfson Research Center, University of Newcastle upon Tyne, UK Jason E. Kanz, PhD: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City Rose Anne Kenny: Wolfson Research Center, University of Newcastle upon Tyne, UK George A. Kuchel, MD: University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington Anand Kumar, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Kelly L. Lange, MD: Department of Psychology, San Diego State University and Department of Psychiatry, School of Medicine, University of California at San Diego Helen Lavretsky, MD: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine David J. Libon, PhD: Department of Psychiatry, Center for Aging, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford Lewis A. Lipsitz, MD: Division on Aging, Harvard Medical School, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, MA Jose G. Merino, MD, MPhil: Department of Neurology, University of Florida, Shands Jacksonville William P. Milberg, PhD: Department of Psychiatry, Harvard Medical School and West Roxbury Department of Veteran Affairs Medical Center, Boston, MA David J. Moser, PhD: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA Mark B. Moss, PhD: Department of Anatomy and Neurobiology and Department of Neurology, Boston University School of Medicine, Boston, MA and Yerkes National Primate Center, Emory University, Atlanta, GA Dan Mungas, PhD: Department of Neurology, University of California at Davis, Sacramento Zsuzsanna Nagy, MD: Department of Pharmacology, University of Birmingham, UK Brian R. Ott, MD: Department of Clinical Neurosciences, Brown Medical School, Providence, RI Robert H. Paul, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Dana L. Penney, PhD: Department of Neurology, Lahey Clinic, Burlington, MA Rebecca E. Ready, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Kenneth Rockwood, PhD: Geriatric Medicine Research Unit, Queen Elizabeth II Health Science Center, Dalhousie University, Halifax, Nova Scotia, Canada Gustavo C. Roman, MD: Geriatric Research Education and Clinical Center, Department of Neurology, University of Texas Health Science Center at San Antonio and the Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio Stephen Salloway, MD, MS: Departments of Clinical Neurosciences and Psychiatry and Human Behavior, Brown Medical School; Department of Neurology, Butler Hospital, Providence, RI Stephen Scheinthal, DO: Department of Psychiatry, Center for Aging, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford Magdy Selim, MD, PhD: Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA Jorge M. Serrador, PhD: Division on Aging, Harvard Medical School, Beth Isreal Deaconess Medical Center, Boston, MA Mary Beth Spitznagel, MS: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sally Stephens: Wolfson Research Center, University of Newcastle Upon Tyne, UK Edward G. Stopa, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI Lawrence Sweet, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Rod Swenson, PhD: Department of Neuroscience, University of North Dakota School of Medicine, Grand Fords, ND David F. Tate, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Geoffrey Tremont, PhD: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI Sharon X. C. Yang, MD: University of Connecticut Center on Aging, University of Connecticut Health Center, Farmington Brian D. Zipser, MD: Division of Neuropathology, Department of Pathology, Brown Medical School, Providence, RI

Table of Contents

Series Editor's Introduction	v
Preface	vii
Contributors	xi
Part I. Introduction
The Aging Population and the Relevance of Vascular Dementia	3	(4)
Kelly L. Lange
Robert H. Paul
Clinical Forms of Vascular Dementia	7	(16)
Gustavo C. Roman
The Neuropathological Substrates of Vascular-Ischemic Dementia	23	(34)
Kurt A. Jellinger
Diagnosis of Vascular Dementia: Conceptual Challenges	57	(18)
Jose G. Merino
Vladimir Hachinski
Part II. Basic Mechanisms of Vascular Dementia
Cerebral Hemodynamics in the Elderly	75	(12)
Jorge M. Serrador
William P. Milberg
Lewis A. Lipsitz
The CADASIL Syndrome and Other Genetic Causes of Stroke and Vascular Dementia	87	(12)
Stephen Salloway
Sophie Desbiens
Estrogen, the Cerebrovascular System, and Dementia	99	(14)
Sharon X. C. Yang
George A. Kuchel
Effects of Hypertension in Young Adult and Middle-Aged Rhesus Monkeys	113	(18)
Mark B. Moss
Elizabeth M. Jonak
Part III. The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living
The Cognitive Profile of Vascular Dementia	131	(14)
Angela L. Jefferson
Adam M. Brickman
Mark S. Aloia
Robert H. Paul
Progression of Cognitive Impairments Associated With Cerebrovascular Disease	145	(12)
Sally Stephens
Raj Kalaria
Rose Anne Kenny
Clive Ballard
Neuropsychiatric Correlates of Vascular Injury: Vascular Dementia and Related Neurobehavioral Syndromes	157	(14)
Anand Kumar
Helen Lavretsky
Ebrahim Haroon
Functional Impairment in Vascular Dementia	171	(10)
Patricia A. Boyle
Deborah Cahn-Weiner
Part IV. Neuroimaging of Vascular Dementia
Functional Brain Imaging of Cerebrovascular Disease	181	(30)
Ronald Cohen
Lawrence Sweet
David F. Tate
Marc Fisher
Contributions of Subcortical Lacunar Infarcts to Cognitive Impairment in Older Persons	211	(12)
Dan Mungas
White Matter Hyperintensities and Cognition	223	(8)
David J. Moser
Jason E. Kanz
Kelly D. Garrett
Poststroke Dementia: The Role of Strategic Infarcts	231	(14)
Anelyssa D'Abreu
Brian R. Ott
Part V. Interactions Between Vascular Dementia and Alzheimer's Disease
Understanding Incidence and Prevalence Rates in Mixed Dementia	245	(12)
John Gunstad
Jeffrey Browndyke
Vascular Basement Membrane Abnormalities and Alzheimer's Disease	257	(10)
Edward G. Stopa
Brian D. Zipser
John E. Donahue
Amyloid Beta and the Cerebral Vasculature	267	(8)
Paula Grammas
Cerebrovascular Disease and the Expression of Alzheimer's Disease	275	(6)
Margaret M. Esiri
Zsuzsanna Nagy
The Neuropsychological Differentiation Between Alzheimer's Disease and Subcortical Vascular Dementia	281	(16)
David J. Libon
Stephen Scheinthal
Dana L. Penney
Rod Swenson
Part VI. Clinical Management of Vascular Dementia
Pharmacological Treatment of Vascular Dementia	297	(8)
Timo Erkinjuntti
Gustavo Roman
Serge Gauthier
Kenneth Rockwood
Understanding and Managing Caregiver Burden in Cerebrovascular Disease	305	(18)
Geoffrey Tremont
Jennifer Duncan Davis
Mary Beth Spitznagel
Quality of Life in Patients With Vascular Dementia	323	(8)
Rebecca E. Ready
Brian R. Ott
Approaches to Neuroprotection and Recovery Enhancement After Acute Stroke	331	(10)
Marc Fisher
Magdy Selim
Index	341	(14)
About the Editors	355