Vascular Disease and Injury

by Simon, Daniel I., M.D.; Rogers, Campbel, M.D.

• ISBN13: 9780896037533
• ISBN10: 0896037533
• Format: Hardcover
• Copyright: 2000-11-01
• Publisher: Humana Pr Inc

Summary

A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.

Author Biography

David H. Adams, MD: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Masanori Aikawa, MD, PhD: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Gary L. Baumbach, MD: Department of Pathology, University of Iowa College of Medicine, Iowa City Andrew J. Carter, DO: Division of Cardiovascular Medicine, Stanford University Medical Center Raymond H. Chen, MD, DPhil: Brigham and Women's Hospital, Harvard Medical School, Boston, MA Zhiping Chen, MS: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Barry S. Coller, MD: Department of Medicine, Mount Sinai School of Medicine, New York Victor J. Dzau, MD: Department of Medicine, Brigham and Women's Hospital, Boston, MA Elazer R. Edelman, MD, PhD, FACC: Division of Health Sciences and Technology, Brigham and Women's Hospital/Harvard-MIT, Cambridge, MA Afshin Ehsan, MD: Research Institute and Department of Medicine, Brigham and Women's Hospital, Boston, MA Daniel T. Eitzman, MD: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor William P. Fay, MD: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor John D. Folts, PhD, FACC: Division of Cardiology, Coronary Thrombosis Research Laboratory, University of Wisconsin-Madison Medical School Yoshihiro Fukumoto, MD, PhD: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA David R. Holmes, Jr., MD: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN Jennifer L. Hoover, BA: Transplantation Biology, Novartis Pharmaceuticals Corporation, Summit, NJ Christopher Horvath, DVM, MS: Millenium Pharmaceuticals Inc., Cambridge, MA Birgit Kantor, MD: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN David Kritchevsky, PhD: Wistar Institute, Philadelphia, PA Peter Libby, MD: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Volkhard Lindner, MD, PhD: Division of Molecular Medicine, Maine Medical Center Research Institute, South Portland Michael J. Mann, MD: Research Institute and Department of Medicine, Brigham and Women's Hospital, Boston, MA Robert P. Marini, DVM: Division of Comparative Medicine, MIT, Cambridge, MA Barbara Meyrick, PhD: Department of Pathology and Center for Lung Research, Vanderbilt University Medical Center, Nashville, TN Richard N. Mitchell, MD, PhD: Department of Pathology, Brigham and Women's Hospital, Boston, MA Claudio Napoli, MD: Department of Medicine, University of California, San Diego Mark Nedelman, MS: Primedica Corporation, Worcester, MA Robert J. Nicolosi, PhD: Center for Chronic Disease Control, University of Massachusetts, Lowell Wulf Palinski, MD: Department of Medicine, University of California, San Diego Andrew C. Parker, BS: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor Marlene Rabinovitch, MD: Division of Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario, Canada Elena Rabkin, MD, PhD: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Peter D. Reaven, MD: Department of Endocrinology, Carl T. Hayden VAMC, Phoenix, AZ Ernane D. Reis, MD: Department of Surgery, Mount Sinai School of Medicine, New York Campbell Rogers, MD, FACC: Cardiovascular Division, Brigham and Women's Hospital/Harvard-MIT, Boston, MA Robert S. Schwartz, MD: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN Philip S. Seifert, MS, HTL (ASCP): Health Sciences and Technology Division Biomedical Engineering Center, MIT, Cambridge, MA Victor Chengwei Shi, MD: Novartis Pharmaceuticals Corporation, Transplantation Biology, Summit, NJ Daniel I. Simon, MD: Cardiovascular Division, Brigham and Women's Hospital, Boston, MA Susan S. Smyth, MD, PhD: Department of Medicine, Mount Sinai School of Medicine, New York Elena Tchekneva, MD: Department of Pathology and Center for Lung Research, Vanderbilt University Medical Center, Nashville, TN Frederick G.P. Welt, MD: Division of Cardiology, Brigham and Women's Hospital/Harvard-MIT, Boston, MA Randal J. Westrick, BS: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor Yanhong Zhu, MD: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor

Table of Contents

Foreword	v
Victor J. Dzau
Preface	vii
Contributors	xiii
Color Plates	xvii
Part I Acute Mechanical Injury and Vascular Repair
Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries	3	(16)
Frederick G.P. Welt
Elazer R. Edelman
Campbell Rogers
The Porcine Model of Coronary Restenosis	19	(24)
Robert S. Schwartz
Birgit Kantor
David R. Holmes Jr.
Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies	43	(10)
Andrew J. Carter
Nonhuman Primate Models of Arterial Injury and Repair	53	(8)
Mark Nedelman
Christopher Horvath
Campbell Rogers
Experimental Models of Arteriovenous Grafting	61	(18)
Afshin Ehsan
Michael J. Mann
Victor J. Dzau
Wire Denudation and Ligation Models of the Mouse Carotid Artery	79	(8)
Volkhard Lindner
Endothelial Denudation and Arterial Dilation in the Mouse	87	(8)
Zhiping Chen
Campbell Rogers
Daniel I. Simon
Vascular Photochemical Injury in the Mouse	95	(8)
Daniel T. Eitzman
Randal J. Westrick
Mouse Model of Transluminal Femoral Artery Injury	103	(14)
Ernane D. Reis
Susan S. Smyth
Barry S. Coller
Part II Models of Arterial Thrombosis
A Murine Model of Arterial Injury and Thrombosis	117	(10)
William P. Fay
Andrew C. Parker
Yanhong Zhu
Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls	127	(22)
John D. Folts
Part III Chronic Atherosclerotic Models
Mouse Models of Atherosclerosis	149	(26)
Wulf Palinski
Claudio Napoli
Peter D. Reaven
Rabbit Models of Atherosclerosis	175	(18)
Masanori Aikawa
Yoshihiro Fukumoto
Elena Rabkin
Peter Libby
Atherosclerosis in Nonhuman Primates	193	(14)
David Kritchevsky
Robert J. Nicolosi
Part IV Vascular Disease in Transplanted Vessels
Murine Carotid Loop Model of Transplant Vascular Disease	207	(8)
Victor Chengwei Shi
Jennifer L. Hoover
Murine Heterotopic Model of Transplant Arteriopathy	215	(16)
Richard N. Mitchell
Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation	231	(16)
Raymond H. Chen
David H. Adams
Part V Vascular Disease in Models of Arterial Hypertension
Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension	247	(14)
Gary L. Baumbach
Monocrotaline-Induced Pulmonary Hypertension in Rats	261	(20)
Marlene Rabinovitch
Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization	281	(22)
Barbara Meyrick
Elena Tchekneva
Part VI Animal Care and Tissue Processing
Veterinary Issues and Anesthesia Options	303	(22)
Robert P. Marini
Histological and Immunohistochemical Methods for Vascular Animal Model Studies	325	(14)
Philip Seifert
Campbell Rogers
Elazer R. Edelman
Index	339