Vascular Morphogenesis in the Female Reproductive System

by Augustin, Hellmut; Iruela-Arispe, M. Luisa; Rogers, Peter A. W.; Smith, Stephen K.

• ISBN13: 9780817642211
• ISBN10: 0817642218
• Format: Hardcover
• Copyright: 2001-08-01
• Publisher: Birkhauser

Summary

The field of angiogenesis is one of the most exciting fields in contemporary biomedical research. Angiogenesis in the healthy adult is primarily associated with pathological conditions such as tumor growth, inflammation, ischemia, and retinopathies. Physiological angiogenesis in the healthy adult is restricted to the organs of the female reproductive system where it occurs cyclically as well as during pregnancy. The importance of vascular morphogenetic events in the female reproductive system is increasingly being recognized. For example, it has a vital role in normal ovarian function, endometriosis and placental function as well as being important in reproductive tumors of the mammary gland, ovary and uterus. The insights gained from studying this system have a more general interest too since they help shed light on the fundamental characteristics and components involved in the formation of the vascular system and blood vessels during development, and during tumorigenesis. This is the first book that reviews and presents recent advances in the emerging field of reproductive vascular biology. It is divided into four parts reflecting the four female reproductive organs (breast, ovary, uterus, and placenta) and the authors cover both the basic biological processes involved and also stress their clinical significance. The book will interest vascular and reproductive biologists as well as cell and developmental biologists interested in angiogenesis and vasculogenesis.

Table of Contents

Contributors	vii
Series Preface	ix
Roger R. Markwald
Preface	xi
Color Insert	84
PART I: VASCULAR MORPHOGENESIS IN THE MAMMARY GLAND:	1	(106)
Vascular Morphogenesis in the Mammary Gland: Introduction and Overview	3	(22)
M. Luisa Iruela-Arispe
Maria Asuncion Ortega
Sarah Oikemus
Michael S. Pepper
Growth Factor Regulation of Physiologic Angiogenesis in the Mammary Gland	25	(16)
Anne Saaristo
Marika J. Karkkainen
Kari Alitalo
Roberto Montesano
M. Luisa Iruela-Arispe
Michael S. Pepper
The Role of Angiogenesis in Breast Cancer Progression	41	(22)
Sandra W. McLeskey
Robert B. Dickson
Angiogenesis in Mammary Tumors: Quantitation and Relation to Prognosis	63	(22)
Stephen B. Fox
Oncogenes, Anti-Oncogenes, and Genetic Regulators of Vascular Development	85	(22)
Timoth F. Lane
Alicia Collado-Hidalgo
PART II: VASCULAR MORPHOGENESIS IN THE OVARY	107	(100)
Vascular Morphogenesis in the Ovary: Introduction and Overview	109	(22)
Hellmut G. Augustin
Growth Factors During Ovarian Angiogenesis	131	(18)
Anna T. Grazul-Bilska
Dale A. Redmer
Lawrence P. Reynolds
Vascular Endothelial Growth Factor: A Key Regulator of Physiologic Angiogenesis	149	(18)
Napoleone Ferrara
Hormonal Regulation of Gonadal Angiogenesis	167	(20)
H. William Schnaper
Constance E. Runyan
Angiogenesis, Vascular Imaging, and Therapeutic Approaches in Ovarian Tumors	187	(20)
Elise C. Kohn
Steven K. Libutti
PART III: VASCULAR MORPHOGENESIS IN THE UTERUS	207	(64)
The Vascular System in the Endometrium: Introduction and Overview	209	(14)
Peter A. W. Rogers
Caroline E. Gargett
The Clinical Relevance of Disturbances of Uterine Vascular Growth, Remodeling, and Repair	223	(22)
Martha Hickey
Ian S. Fraser
Angiogenesis in Endometriosis	245	(26)
Michael D. Mueller
Robert N. Taylor
PART IV: VASCULAR MORPHOGENESIS IN THE PLACENTA	271	(56)
Placental Vascular Morphogenesis: Introduction and Overview	273	(12)
D. Stephen Charnock-Jones
Stephen K. Smith
Placental Functional Morphology	285	(16)
Graham J. Burton
Placenta Growth Factor	301	(14)
M. Graziella Persico
Early Placental Vascular Morphogenesis	315	(12)
Caroline H. Damsky
Susan J. Fisher
Index	327