Venous Thrombosis in Women: Pregnancy, the Contraceptive Pill and Hormone Replacement Therapy

by Greer; Ian A.

• ISBN13: 9781842142288
• ISBN10: 1842142283
• Format: Hardcover
• Copyright: 2003-04-28
• Publisher: CRC Press

Summary

Univ. of Glasgow, UK. Text provides an overview of venous thrombosis in women during different stages of life. Discusses hemostasis and fibrinolysis during pregnancy, hemostatic effects of the combined oral contraceptive pill, and the risk factors of hormone replacement. Halftone illustrations. Extensive references.

Table of Contents

Overview of the hemostatic and fibrinolytic systems	p. 7
Physiological changes in hemostasis and fibrinolysis in pregnancy	p. 15
Platelets in pregnancy	p. 16
Coagulation factors	p. 16
Endogenous anticoagulants and pregnancy	p. 17
Fibrinolysis	p. 18
Summary: hemostasis in normal pregnancy	p. 19
Venous thromboembolism in pregnancy	p. 21
The problem of venous thromboembolism in pregnancy	p. 22
Risk factors for VTE in pregnancy	p. 23
Long-term morbidity from pregnancy-associated VTE	p. 26
Pathophysiology of pregnancy-associated VTE	p. 27
Thrombophilia and pregnancy-associated venous thrombosis	p. 29
Thrombophilia and adverse pregnancy outcome	p. 34
Screening for congenital thrombophilia in pregnancy	p. 39
Diagnosis of VTE in pregnancy	p. 41
Antithrombotic therapy in pregnancy	p. 44
Management of acute gestational VTE	p. 47
Labor and Cesarean section in the woman with VTE in pregnancy	p. 51
Thromboprophylaxis in pregnancy	p. 52
Venous thromboembolism and the oral contraceptive pill	p. 59
Epidemiology of venous thromboembolism and the oral contraceptive pill	p. 60
Heritable thrombophilia and the oral contraceptive pill	p. 64
Hemostatic effects of the combined oral contraceptive pill	p. 66
Implications for practice	p. 66
Venous thromboembolism and hormone replacement therapy	p. 69
Epidemiology of venous thromboembolism and hormone replacement therapy	p. 70
Potential mechanisms underlying the association between HRT and VTE	p. 76
Thrombophilia, HRT and risk of VTE	p. 78
Risk factors for VTE and HRT	p. 79
HRT and VTE: implications for management	p. 81
References	p. 85
Index	p. 107
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