Viral Genome Replication

by Cameron, Craig E.; Götte, Matthias; Raney, Kevin D.

• ISBN13: 9780387894256
• ISBN10: 038789425X
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-08-04
• Publisher: Springer Verlag

Summary

Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy of all viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets targets for the development of antiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of antiviral agents. By combining studies of both RNA and DNA viruses - and more - into a single volume, the editors have created a mechanism for cross-talk between the fields that will produce synergy and could lead to more rapid discovery of approaches to treat viral infections.

Table of Contents

Genome Replication Strategies
Model of Picornavirus RNA Replication	p. 3
Coronavirus Genome Replication	p. 25
Flaviviruses	p. 41
Hepatitis C Virus Genome Replication	p. 61
Brome Mosaic Virus RNA Replication and Transcription	p. 89
Retroviruses	p. 109
Hepadnaviral Genomic Replication	p. 129
Rhabdoviruses	p. 145
Orthomyxovirus Genome Transcription and Replication	p. 163
Arenaviruses: Genome Replication Strategies	p. 181
Core-Associated Genome Replication Mechanisms of dsRNA Viruses	p. 201
Poxviruses	p. 225
Herpesvirus Genome Replication	p. 249
Host Factors Promoting Viral RNA Replication	p. 267
Host Factors that Restrict Retrovirus Replication	p. 297
Elements, Factors and Enzymes: Structure-Function and Mechanism
T4 Phage Replisome	p. 337
Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase	p. 365
RNA Virus Polymerases	p. 383
Human Immunodeficiency Virus Reverse Transcriptase	p. 403
Viral Helicases	p. 429
Integrase: Structure, Function, and Mechanism	p. 467
Antivirals: Targets, Mechanisms and Resistance
Viral DNA Polymerase Inhibitors	p. 481
Viral RNA Polymerase Inhibitors	p. 527
HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance	p. 549
Lethal Mutagenesis	p. 571
Clinical Implications of Reverse Transcriptase Inhibitor Resistance	p. 589
Index	p. 621
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