Virulence Mechanisms of Bacterial Pathogens

by Roth, James A.

• ISBN13: 9781555810856
• ISBN10: 1555810853
• Edition: 2nd
• Format: Hardcover
• Copyright: 1995-06-01
• Publisher: Amer Society for Microbiology

Summary

This is the second edition of a landmark book, originally published in 1988. the new edition has been extensively revised and updated to provide an overview of the current state of knowledge of how bacterial pathogens go about establishing infections, producing disease, and persisting in the host. Strategies for overcoming bacterial virulence mechanisms are also covered. This book will appeal strongly to molecular biologists wanting an understanding of how molecular mechanisms relate to disease, as well as infectious disease

Table of Contents

Organizing Committee	ix	(2)
Authors	xi	(4)
Preface	xv	(2)
Acknowledgments	xvii
I. BACTERIAL ADHERENCE, COLONIZATION, AND INVASION ON MUCOSAL SURFACES	3	(46)
Kim A. Brogden
1. Attachment and Interaction of Bacteria at Respiratory Mucosal Surfaces	3	(18)
Diana R. Cundell
E. Tuomanen
2. Paradigms in Bacterial Entry into Host Cells	21	(12)
Michael K. Zierler
Jorge E. Galan
3. Mechanisms of Mucosal Colonization and Penetration by Bacterial Pathogens	33	(16)
B. Brett Finlay
Annette Siebers
II. BACTERIAL ADAPTATION TO EXTRACELLULAR ENVIRONMENTS	49	(50)
Carole A. Bolin
4. Resistance of Bacteria to Complement	49	(16)
Peter W. Taylor
5. Quorum Sensing and Virulence Gene Regulation in Pseudomonas aeruginosa	65	(14)
Luciano Passador
Barbara H. Iglewski
6. Acquisition of Iron and Other Nutrients In Vivo	79	(20)
Eugene D. Weinberg
III. BACTERIAL RESISTANCE TO CELLULAR DEFENSE MECHANISMS	99	(74)
Michael J. Wannemuehler
7. Role of Mycobacterial Constituents in Regulation of Macrophage Effector Function	99	(16)
James L. Krahenbuhl
8. Microbial Resistance to Macrophage Effector Functions: Strategies for Evading Microbicidal Mechanisms and Scavenging Nutrients within Mononuclear Phagocytes	115	(18)
Andreas J. Baumler
Fred Heffron
9. Francisella tularensis, a Model Pathogen to Study the Interaction of Facultative Intracellular Bacteria with Phagocytic Host Cells	133	(12)
Anne H. Fortier
Carol A. Nacy
Tammy Polsinelli
Nirupama Bhatnagar
10. Bacterial Superantigens in Disease	145	(28)
Allen D. Sawitzke
Kevin L. Knudtson
Barry C. Cole
IV. BACTERIAL TOXINS IN DISEASE PRODUCTION	173	(72)
F. Chris Minion
11. Lipopolysaccharide and Bacterial Virulence	173	(22)
Richard A. Proctor
Loren C. Denlinger
Paul J. Bertics
12. Phylogenetic Analyses of the RTX Toxin Family	195	(12)
Rodney A. Welch
13. Pore-Forming Toxins of Gram-Positive Bacteria	207	(24)
Rodney K. Tweten
14. Bacterial ADP-Ribosylating Exotoxins	231	(14)
Kathleen M. Krueger
Joseph T. Barbieri
V. STRATEGIES TO OVERCOME BACTERIAL VIRULENCE MECHANISMS	245	(90)
James A. Roth
15. Ecological Concepts in the Control of Pathogens	245	(12)
Kenneth H. Wilson
16. Enhancement of Nonspecific Resistance to Bacterial Infection by Biological Response Modifiers	257	(12)
Charles J. Czuprynski
17. Vaccination Strategies for Mucosal Pathogens	269	(34)
Suzanne M. Michalek
Noel K. Childers
Mark T. Dertzbaugh
18. Induction of Cytokine Formation by Bacteria and Their Products	303	(32)
Anthony C. Allison
Elsie M. Eugui
VI. PAST, PRESENT, AND FUTURE STUDIES	335	(24)
19. The State and Future of Studies on Bacterial Pathogenicity	335	(24)
H. Smith
Index	359