Vitamin D: An Issue of Rheumatic Disease Clinics of North America

by Epstein, Sol, M.D.

• ISBN13: 9781455739318
• ISBN10: 1455739316
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-05-01
• Publisher: SAUNDERS W B CO

Summary

This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feedback loops were identified between vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in autoimmune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders, and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.

Table of Contents

Preface	p. xiii
Vitamin D: Metabolism	p. 1
The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by1,25-Dihydroxyvitamin D3	p. 13
Assessment and Interpretation of Circulating 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment	p. 29
Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction	p. 45
Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets	p. 61
Osteomalacia as a Result of Vitamin D Deficiency	p. 81
Genetic Disorders and Defects in Vitamin D Action	p. 93
Vitamin D and Fracture Prevention	p. 107
Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment	p. 115
Vitamin D and the Immune System: New Perspectives on an Old Theme	p. 125
Vitamin D: Extraskeletal Health	p. 141
The Role of Vitamin D in Cancer Prevention and Treatment	p. 161
Vitamin D and Diabetes	p. 179
Vitamin D Analogs	p. 207
Index	p. 233
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