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9780521104753

In Vitro Methods in Toxicology

by
  • ISBN13:

    9780521104753

  • ISBN10:

    0521104750

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2009-03-19
  • Publisher: Cambridge University Press
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Supplemental Materials

What is included with this book?

Summary

First published in 1987, this book describes tissue (cell and organ) culture techniques which could be used at a critical predevelopment stage to screen for drug-inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studies. This type of research has important ethical, financial and scientific implications. In particular, less animals and compound are required in in vitro research and more detailed information at the cellular and subcellular levels can be obtained. The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists. It could also form a framework for discussion of potential improvements and modification of toxicity testing.

Table of Contents

Introduction
Target Organ Toxicity
In vitro methods in renal toxicology
Ototoxicity
Cultured cell models for studying problems in cardiac toxicology
Use of the isolated rat heart for the detection of cardiotoxic agents
Brain reaggregate cultures in neurotoxicological investigations
Application of thyroid cell culture to the study of thyrotoxicity
In vitro methods to investigate toxic lung disease
Metabolism and toxicity of drugs in mammalian hepatocyte culture
In vitro evaluation of haemic systems in toxicology
General and Topical Toxicity
The chorioallantoic membrance in irritancy testing
In vitro dermal irritancy tests
Genetic toxicology
In vitro immunotoxicology
Reproductive Toxicity
An in vitro test for teratogens using cultures of rat embryo cells
Postimplantion embryo culture and its application to problems in teratology
Sub-mammalian and sub-vertebrate models in teratogenicity screening
The use of in vitro techniques to investigate the action of testicular toxicants
An in vitro assessment of ovarian function: a potential tool for investigating mechanisms of toxicity in the ovary
Conclusion
Conclusion
Index
Table of Contents provided by Publisher. All Rights Reserved.

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