In Vitro Neurotoxicology

by Tiffany-Castiglioni, Evelyn; Hollinger, Mannfred A.

• ISBN13: 9781588290472
• ISBN10: 1588290476
• Format: Hardcover
• Copyright: 2004-02-01
• Publisher: Humana Pr Inc

Summary

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

Table of Contents

Dedication	v
Foreword	vii
Preface	ix
Contributors	xiii
In Vitro Neurotoxicology: Introduction to Concepts	1	(28)
Evelyn Tiffany-Castiglioni
Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment	29	(12)
Marion Ehrich
David C. Dorman
Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics	41	(18)
William H. Hanneman
Melvin E. Andersen
Marie E. Legare
Christine T. French
Tami S. McMullin
Carolyn Broccardo
Ruth E. Billings
In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis	59	(36)
Gerald J. Audesirk
Ronald B. Tjalkens
Role of Apoptosis in Neurotoxicology	95	(38)
Lori D. White
Sid Hunter
Michael W. Miller
Marion Ehrich
Stanley Barone, Jr.
Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants: Enzyme Pathways in Neurons and Astroglia	133	(18)
Michael Aschner
Ursula Sonnewald
Cell-Type-Specific Responses of the Nervous System to Lead	151	(36)
Evelyn Tiffany-Castiglioni
Yongchang Qian
Effects of Toxicants on Neural Differentiation	187	(30)
Stanley Barone, Jr.
Prasada R. S. Kodavanti
William R. Mundy
Impairment of Synaptic Function by Exposure to Lead	217	(26)
Stephen M. Lasley
Mary E. Gilbert
Aggregating Brain Cell Cultures for Neurotoxicological Studies	243	(24)
Marie-Gabrielle Zurich
Florianne Monnet-Tschudi
Lucio G. Costa
Benoit Schilter
Paul Honegger
Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors	267	(24)
W. Les Dees
Jill K. Hiney
Robert K. Dearth
Vinod K. Srivastava
Establishing In Vitro Models to Study Endogenous Neurotoxicants	291	(24)
Heather D. Durham
Appendix: Annotated Reading List	315	(10)
Evelyn Tiffany-Castiglioni
Lucio G. Costa
Marion Ehrich
William R. Mundy
Gerald J. Audesirk
Michael Aschner
Prasada R. S. Kodavanti
Stephen M. Lasley
Index	325