Summary

The Wiley Encyclopedia of Chemical Biology is an authoritative new work whose goal is to illuminate the crucial role of chemistry and chemical techniques in the life sciences. The encyclopedia will adopt an inclusive editorial approach, encompassing fundamental and blue-sky science as well as those areas of research that have more immediate medical or commercial applications. The scope and structure of the work will reflect the multidimensional character of chemical biology, focusing in particular on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate that science, and the applications of this knowledge in areas as diverse as drug discovery, sensor technology, and catalysis.Major topics areas covered in the encyclopedia: Chemical Views of Biology Biomolecules within the Cell Chemistry of Biological Processes and Systems Chemical Biology of Cellular Compartments Synthetic Molecules as Tools for Chemical Biology Technologies and Techniques in Chemical Biology Applications of Chemical Biology

Author Biography

Tadhg P. Begley is Professor of Chemistry and Chemical Biology at Cornell University. Begley (PhD, California Institute of Technology, 1983) is a leading figure in the chemical biology community. He is the recipient of a number of awards for teaching and research, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher-Scholar Award.

ADME properties of drugs
AdoMet-dependent methyltransferases
Chemistry of Alkaloid Biosynthesis
Allergy and Asthma
Small Molecules to Target
Amino Acids
Chemical Properties of Aminoacyl tRNA Synthetases
Chemistry of Amyloid Formation
Antibiotics
Bacterial Resistance to Antibiotics
Biosynthesis of Anxiety Disorders
Macromolecular Pathways and Interactions
Apoptosome and Caspase Activation
Artificial Metalloproteins
Design and Engineering of ATP Synthesis
Chemistry of Attenuation
Control of Gene Expression by B12-Dependent Enzyme Reactions
Chemistry of Bacterial DNA Polymerases
Chemistry of Bacteriorhodopsin
Chemistry of Biocatalysis and Biotransformation
Biocatalysts and Chemocatalysts in the Pharmaceutical Industry
Biocompatibility of Materials in Medical Devices
Calcium Pump
Chemistry of Calcium Signaling
Carbohydrate-Carbohydrate Interactions
Catalytic Antibodies (abzymes)
Synthetic Catalytic Modes in Natural Ribozymes
Cell Cycle
Regulation of Cell Death
Biological Mechanisms and Small Molecule Inhibitors of Cell Membranes
Dynamics of Cellular Energy Metabolism and Integrated Oxidative Phosphorylation
Chaperones
Molecular Chemical Libraries to Screen for Biologically Active Small Molecules
Chemical Molecules that Regulate Transcription and Facilitate Cell-to-Cell Communication
Chlorophylls and Carotenoids, Chemistry of Chromosome Formation
Chronic Obstructive Pulmonary Disease (COPD), Mechanisms of Circular Dichroism for Natural Products
Click Peptides
Design and Applications of CoA-Dependent Enzymes
Chemistry of Cofactor Biosynthesis
Collagen Triple Helix
Stability of Combinatorial Libraries: Overview of Applications in Chemical Biology
Controlled Drug Delivery: Pharmacokinetic Considerations, Methods and Systems
Cyclooxygenase Inhibition
Recent Advances in the Mechanisms of Cytochrome P450 Monooxygenases
Chemistry of Cytosolic Glycosylated Proteins
Chemistry of Depression
Chemical Mechanisms of Differential Scanning Calorimetry to Study Lipids and Lipid Membranes
Directed Evolution
Novel and Improved Enzymes through
DNA Damage Repair
Chemistry of DNA Damage
Sensing of DNA Helicases
Chemistry and Mechanisms of DNA Polymorphisms
Tools to Detect DNA Transposition: Topics in Chemical Biology
DNA-Conjugated Organic Chromophores in DNA Stacking Interactions
Drug Design Strategies for Targeting G-Protein-Coupled Receptors
Drug Discovery and Development
Computational Approaches in Drug Transport in Living Systems
Electron paramagnetic resonance (EPR) in Enzymology
Electron Transfer
Chemical Roles of Water in Endocytosis
Receptor-Mediated
Endoplasmic Reticulum: Topics in Chemical Biology
Enzymatic Synthesis of Carbohydrate-Containing Biomolecules
Enzyme Catalysis
Chemical Strategies for Enzyme Inhibition
Approaches to Enzyme Kinetics
Epigenetic Modifications
Essential Fatty Acids
Physiology and Clinical Significance of Fatty Acid Desaturases
Chemistry of Flavin-Mediated Hydroxylation Reactions
Flavoenzymes
Chemistry of Fluorescence in Living Systems: Overview of Applications in Chemical Biology
Fluorescence Spectroscopy: Overview of Applications in Chemical
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