Williams Hematology, Eighth Edition

The landmark hematology reference --- now in full colorEdition after edition,Williams Hematologyhas guided generations of clinicians, biomedical researchers, and trainees of many disciplines through the origins, pathophysiological mechanisms and management of benign and malignant disorders of blood cells and coagulation proteins.The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present a complete treatment of disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.Featuring a brand-new full-color presentation, the Eighth Edition ofWilliams Hematologyis extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders.New to this Edition: Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text Two additional chapters, "Epigenetics and Genomics," and "Principles of Multipotential Cell Therapy for Tissue Replacement," offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches Companion DVD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format

Author Profile
The Williams' editorial team truly represents the cream of the crop of research and clinical hematology. The editors are all known worldwide for their contributions to the field. Three editors are previous or current Presidents of the American Society of Hematology.

The editor-in-chief of the 8th edition, Kenneth Kaushansky MD, is Chairman of Medicine at the University of California San Diego School of Medicine. He is current Present of the American Society of Hematology.

Contributors
Preface
PART I: CLINICAL EVALUATION OF THE PATIENT
1. Initial Approach to the Patient: History and Physical Examination, Marshal A. Lichtman and Ernest Beutler
2. Examination of Blood Cells, Daniel H. Ryan
3. Examination of the Marrow, Daniel H. Ryan
PART II: THE ORGANIZATION OF THE LYMPHOHEMATOPOIETIC TISSUES
4. Structure of the Marrow and the Hematopoietic Microenvironment, Mark J. Koury and Marshall A. Lichtman
5. The Organization and Structure of Lymphoid Tissues, Thomas J. Kipps
PART III: EPOCHAL HEMATOLOGY
6. Hematology of the Fetus and Newborn, James Palis and George B. Segel
7. Hematology during Pregnancy, Martha P. Mims and Josef T. Prchal
8. Hematology in Older Persons, William B. Ershler and Dan L. Longo
PART IV: MOLECULAR AND CELLULAR HEMATOLOGY
9. Genetic Principles and Molecular Biology, Ernest Beutler
10. Genomics and Epigenetics, Lynn B. Jorde
11. Cytogenetics and Molecular Abnormalities, Lucy A. Godley and Michelle M. Le Beau
12. Apoptosis, Roberta A. Gottlieb
13. Cell-Cycle Regulation and Hematologic Disorders, Mathias Schmid and Dennis A. Carson
14. Signal Transduction Pathways, Kenneth Kaushansky
15. The Cluster of Differentiation Antigens, Thomas J. Kipps
16. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky
17. The Inflammatory Process, Jeffrey S. Warren and Peter A. Ward
18. Innate Immunity, Bruce Beutler
19. Dendritic Cells and the Control of Innate Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman
PART V: THERAPEUTIC PRINCIPLES
20. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Jeffrey Barnes, James Cleary, Andrew Lane, Constantine Mitsiades, and Paul Richardson
21. Principles of Hematopoietic Cell Transplantation, Robert Lowsky and Robert S. Negrin
22. Treatment of Infections in the Immunocompromised Host, Steven Beutler and Lisa Beutler
23. Principles of Antithrombotic Therapy, Charles W. Francis and Mark Crowther
24. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell
25. Principles of Vaccine Therapy, Sattva S. Neelapu and Larry W. Kwak
26. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications, Bruce C. McLeod
27. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps
28. Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement, Armand Keating
PART VI: THE ERYTHROCYTE
29. Morphology of the Erythron, Brian S. Bull and Paul C. Herrmann
30. Composition of the Erythrocyte, Ernest Beutler
31. Production of Erythrocytes, Josef T. Prchal
32. Destruction of Erythrocytes, Ernest Beutler
33. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal
34. Aplastic Anemia: Acquired and Inherited, George B. Segel and Marshall A. Lichtman
35. Pure Red Cell Aplasia, Neal S. Young
36. Anemia of Chronic Renal Disease, Jaime Caro and Ubaldo Martinez Outschoorn
37. Anemia of Chronic Disease, Tomas Ganz
38. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal
39. The Congenital Dyserythropoietic Anemias, Jean Delaunay
40. Paroxysmal Nocturnal Hemoglobinuria, Charles J. Parker
41. Folate, Cobalamin, and Megaloblastic Anemias, Ralph Green
42. Disorders of Iron Metabolism, Ernest Beutler
43. Anemia Resulting from Other Nutritional Deficiencies, Ralph Green
44. Anemia Associated with Marrow Infiltration, Archana M. Agarwal and Josef T. Prchal
45. The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseaes, Patrick G. Gallagher
46. Disorders of Red Cells Resulting from Enzyme Abnormalities, Wouter W. van Solinge and Richard van Wijk
47. The Thalassemias: Disorders of Globin Synthesis, David J. Weatherall
48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Kavita Natarajan, Tim M. Townes, and Abdullah Kutlar
49. Methemoglobinemia and Other Dyshemoglobinemias, Neeraj Agarwal and Josef T. Prchal
50. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake
51.Hemolytic Anemia Resulting from Chemical and Physical Agents, Brian S. Bull and Paul C. Herrmann
52. Hemolytic Anemia Resulting from Infections with Microorganisms, Marshall A. Lichtman
53. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman
54. Alloimmune Hemolytic Disease of the Fetus and Newborn, Jayashree Ramasethu and Naomi L. C. Luban
55. Hypersplenism and Hyposlenism, Jaime Caro and Ubaldo Martinez Outschoorn
56. Primary and Secondary Polycythemias (Erythrocytosis), Josef T. Prchal
57. The Porphyrias, John D. Phillips and Karl E. Anderson
58. Hereditary and Acquired Sideroblastic Anemias, Prem Ponka and Josef T. Prchal
PART VII: NEUTROPHILS, EOSINOPHILS, BASOPHILS, AND MAST CELLS
59. Morphology of Neutrophils, Eosinophils, and Basophils, C. Wayne Smith
60. Composition of Neutrophils, C. Wayne Smith
61. Production, Distribution, and Fate of Neutrophils, C. Wayne Smith
62. Eosinophils and Their Disorders, Andrew J. Wardlaw
63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak
64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman
65. Neutropenia and Neutrophilia, David C. Dale
66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer
PART VIII: MONOCYTES AND MACROPHAGES
67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Florin Tuluc
68. Biochemistry and Functions of Monocytes and Macrophages, Annette Pluddemann and Siamon Gordon
69. Production, Distribution, and Fate of Monocytes and Macrophages, Siamon Gordon and Annette Pluddemann
70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman
71. Monocytosis and Monocytopenia, Marshall A. Lichtman
72. Inflammatory and Malignant Histiocytosis, Kenneth L. McClain and Carl E. Allen
73. Lipid Storage Diseases, Ari Zimran and Deborah Elstein
PART IX: LYMPHOCYTES AND PLASMA CELLS
74. Morphology of Lymphocytes and Plasma Cells, H. Elizabeth Broome
75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps
76. Lymphopoiesis, Gay M. Crooks
77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps
78. Functions of T Lymphocytes: T-Cell Receptors for Antigen, Thomas J. Kipps
79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier
80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps
81. Lymphocytosis and Lymphocytopenia, Thomas J. Kipps
82. Immunodeficiency Diseases, Hans D. Ochs and Luigi D. Notarangelo
83. Hematologic Manifestations of Acquired Immunodeficiency Syndrome, Erin Gourley Reid
84. Mononucleosis Syndromes, Robert F. Betts
PART X: NEOPLASTIC MYELOID DISEASES
85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman
86. Polycythemia Vera, Josef T. Prchal and Jaroslav F. Prchal
87. Essential Thrombocythemia, Philip A. Beer and Anthony R. Green
88. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia), Jane L. Liesveld and Marshall A. Lichtman
89. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman
90. Chronic Myelogenous Leukemia and Related Disorders, Jane L. Liesveld and Marshall A. Lichtman
91. Primary Myelofibrosis, Marshall A. Lichtman and Ayalew Tefferi
PART XI: NEOPLASTIC LYMPHOID DISEASES
92. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps and Huan-You Wang
93. Acute Lymphoblastic Leukemia, Ching-Hon Pui
94. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps
95. Hairy Cell Leukemia, Darren Sigal and Alan Saven
96. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin
97. General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodel Disease, Kenneth A. Foon and Marshall A. Lichtman
98. Pathology of Malignant Lymphomas, Randy D. Gascoyne and Kenneth A. Foon
99. Hodgkin Lymphoma, Sandra J. Horning
100. Diffuse Large B-Cell Lymphoma, Michael Boyiadzis and Kenneth A. Foon
101. Follicular Lymphoma, Oliver W. Press
102. Mantle Cell Lymphoma, Jorge E. Romaguera and Peter W. McLaughlin
103. Marginal Zone B-Cell Lymphomas, Emanuele Zucca
104. Burkitt Lymphoma, Jonathan W. Friedberg and Archibald S. Perkins
105. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome), Larisa J. Geskin
106. Mature T-Cell and Natural Killer Cell Lymphomas, Oscar B. Goodman, Jr. and Nam H. Dang
107. Plasma Cell Neoplasms: General Considerations, H. Elizabeth Broome
108. Essential Monoclonal Gammopathy, Marshall A. Lichtman
109. Myeloma, Frits van Rhee, Elias Anaissie, Edgardo Angtuaco, Twyla Bartel, Joshua Epstein, Bijay Nair, John Shaughnessy, Shmuel Yaccoby, and Bart Barlogie
110. The Amyloidoses, Vaishali Sanchorawala, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum
111. Macroglobulinemia, Steven P. Treon and Giampaolo Merlini
112. Heavy-Chain Disease, Dietlind L. Wahner-Roedler and Robert A. Kyle
PART XII: HEMOSTATIS AND THROMBOSIS
113. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky
114. Platelet Morphology, Biochemistry, and Function, Susan S. Smyth, Sidney Whiteheart, Joseph E. Italiano, Jr. and Barry S. Coller
115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Dougald M. Monroe, III, Maureane Hoffman, and Harold R. Roberts
116. Control of Coagulation Reactions, John H. Griffin
117. Vascular Function in Hemostatis, Katherine A. Hajjar, Aaron J. Marcus, and William Muller
118. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky
119. Thrombocytopenia, Reyhan Diz-Kucukkaya, Junmei Chen, Amy Geddis, and Jose A. Lopez
120. Reactive Thrombocytosis, Kenneth Kaushansky
121. Hereditary Qualitative Platelet Disorders, Barry S. Coller, Deborah L. French, and A. Koneti Rao
122. Acquired Qualitative Platelet Disorders, Charles S. Adams, Sanford J. Shattil, and Joel S. Bennett
123. The Vascular Purpuras, Doru T. Alexandrescu and Richard L. Gallo
124. Hemophilia A and Hemophilia B, Harold R. Roberts, Nigel S. Key, adn Miguel A. Escobar
125. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Ophira Salomon
126. Hereditary Fibrinogen Abnormalities, Marguerite Neerman-Arbez and Philippe de Moerloose
127. Von Willebrand Disease, Jill Johnsen and David Ginsburg
128. Antibody-Mediated Coagulation Factor Deficiencies, Pete Lollar
129. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. De Groot
130. Disseminated Intravascular Coagulation, Marcel Levi and Uri Seligsohn
131. Hereditary Thrombophilia, Uri Seligsohn and Aharon Lubetsky
132. The Antiphospholipid Syndrome, Jacob H. Rand
133. Antibody-Mediated Thrombotic Disorders: Thrombotic-Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz
134. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo
135. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schafer
136. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Jia Ruan
PART XIII: TRANSFUSION MEDICINE
137. Erythrocyte Antigens and Antibodies, Marion E. Reid
138. Human Leukocyte and Platelet Antigens, Myra Coppage, David Stroncek, Janice McFarland, and Neil Blumberg
139. Blood Procurement and Screening, Jeffrey McCullough
140. Red Cell Transfusion, Norma B. Lerner, Majed A. Rafaai, and Neil Blumberg
141. Preservation and Clinical Use of Platelets, Mike Murphy and Ralph Vassallo
Index

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