Workbook for Organic Synthesis Strategy and Control

by Wyatt, Paul; Warren, Stuart

• ISBN13: 9780470758830
• ISBN10: 047075883X
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-07-08
• Publisher: Wiley

Summary

This workbook accompanies Organic Synthesis: Strategy and Control, the bestselling advanced organic textbook Provides a complete course for advanced organic students and includes a graded set of problems, solutions and discussions to illustrate and develop the themes of each of the chapters in the textbook

Author Biography

Dr Paul Wyatt, School of Chemistry, University of Bristol, Bristol
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning.

Dr Stuart Warren, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge
Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley) and Organic Synthesis (OUP)

Table of Contents

Preface

Introduction: Selectivity.

Planning Organic Syntheses: Tactics, Strategy and Control

Chemoselectivity

Regioselectivity: Controlled Aldol Reactions

Stereoselectivity: Stereoselective Aldol Reactions

Alternative Strategies for Enone Synthesis

Choosing a Strategy: The Synthesis of Cyclopentenones

Making Carbon-Carbon Bonds.

The Ortho Strategy for Aromatic Compounds

?-Complexes of Metals

Controlling the Michael Reaction

Specific Enol Equivalents

Extended Enolates

Allyl Anions

Homoenolates

Acyl Anion Equivalents

CarbonûCarbon Double Bonds.

Synthesis of Double Bonds of Defined Stereochemistry

Vinyl Anions

Electrophilic Attack on Alkenes

Vinyl Cations

Allyl Alcohols: Allyl Cation Equivalents (and More)

Stereochemistry.

Control of Stereochemistry ù Introduction

Diastereoselectivity

Resolution

The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials

Asymmetric Induction I: Reagent-Based Strategy

Asymmetric Induction II: Asymmetric Catalysis: Formation of CûO and CûN Bonds

Asymmetric Induction III: Asymmetric Catalysis: Formation of CûH and CûC Bonds

Asymmetric Induction IV: Substrate-Based Strategy

Kinetic Resolution

Enzymes: Biological Methods in Asymmetric Synthesis

New Chiral Centres from Old: Enantiomerically Pure Compounds & Sophisticated Syntheses

Strategy of Asymmetric Synthesis

Functional Group Strategy.

Functionalisation of Pyridine

Oxidation of Aromatic Rings and of Enol(ate)s

Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements

Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms

Tandem Organic Reactions

Index

Table of Contents provided by Publisher. All Rights Reserved.