Xenopus Development

by Kloc, Malgorzata; Kubiak, Jacek Z.

• ISBN13: 9781118492819
• ISBN10: 1118492811
• Edition: 1st
• Format: Hardcover
• Copyright: 2014-06-03
• Publisher: Wiley-Blackwell

Summary

Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in  various disciplines of biological science.

Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research.

Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research.

• Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis
• Explores cellular to systems development in key biomedical model organisms
• Timely synthesis of the field of Xenopus biology
• Highlights key biomedical and basic biological findings unlocked by Xenopus

Author Biography

Malgorzata Kloc is the Weill Cornell Professor of Cell and Molecular Biology and Director of the Immuno-Biology Laboratory at the Houston Methodist Hospital Research Institute and Adjunct Associate Professor at the University of Texas M D Anderson Cancer Center

Jacek Z. Kubiak is a DR2 Researcher in the CNRS at the Institute of Genetics and Development and at the University of Rennes 1

Table of Contents

I.    Oocyte and early embryo

 

1. Polarity, cell cycle control and developmental potential of Xenous laevis oocyte. Malgorzata Kloc & Jacek Z. Kubiak. (The Methodist Hospital, Houston, USA & IGDR, CNRS/Univ. Rennes 1, France).

2. Cell cycle regulation & cytoskeleton in Xenopus. Marc W. Kirschner (Harvard University, USA) or Kinases and phosphatases in Xenopus oocytes and embryos. Tim Hunt (University of Cambridge, GB)

or Randall W. King (Harvard University, USA).

3. DNA replication and repair in Xenopus. Julian J. Blow (University of Dundee, Wellcome Trust Centre for Gene Regulation & Expression, GB) or Marcel Méchali (IGH, CNRS, Montpellier, France).

4.   Gene expression in Xenopus laevis development and nuclear transfer. John B. Gurdon (The Wellcome Trust/Cancer Research UK Gurdon Institute, GB).

5.   Translational control in Xenopus development. Joel D. Richter (Univ. of Massachusetts, USA).

 

II. Midblastula transition, gastrulation and neurulation

 

6.   Apoptosis in Xenopus embryos. Sally Kornbluth (Duke University, USA) or

Jean Gautier Columbia University College of Physicians and Surgeons, New York, USA.

7.   Cell cleavage and polarity in Xenopus leavis embryo epithelium. Jean-Pierre Tassan (IGDR, CNRS/Univ. Rennes, France) or John B. Wallingford (University of Texas at Austin, TX, USA)

8.   Germ cell specification, Mary Lou King (University of Miami, USA).

9.   Mesoderm formation in Xenopus. James C. Smith (The Gurdon Institute, GB) or Laurent Kodjabachian (CNRS/Univ. Provence, Marseille, France) or Sergei Y. Sokol (Mount Sinai School of Medicine, New York, USA) or Eddy De Robertis (University of California, Los Angeles, USA) or

Pierre McCrea (MDAnderson Cancer Center, Houston TX, USA).

10. Neural tube formation in Xenopus. Naoto Ueno (National Institute for Basic Biology, Okazaki, Japan.).

11. Left-right axis control in Xenopus development. Ali H. Brivanlou (The Rockefeller University, New York, USA).

 

III. Metamorphosis and organogenesis

 

12. Metamorphosis and endocrine system development in Xenopus. Barbara A. Demeneix (CNRS, Paris, France).

13. Xenopus laevis kidney development. Rachel Miller (MD Anderson Cancer Center, University of Texas, Houston, USA).

14. Xenopus nervous system development. Christine E. Holt (Cambridge University, GB) or Eric J. Bellefroid (Université Libre de Bruxelles, Institut de biologie et de médecine moléculaires, Belgium).

15. Gonads development in Xenopus and other anurans. Rafal P. Piprek (Jagiellonian University, Krakow, Poland).

16. Immune system development in Xenopus. Louis Du Pasquier (Universität Basel, Switzerland).

 

IV. Novel techniques and approaches

 

17. MicroRNA in Xenopus development. Nancy Papalopulu (University of Manchester, GB).

18. Genetics of Xenopus tropicalis development. Richard M. Harland (University of California, Berkeley, USA) or Nicolas Pollet (Institute of Systems and Synthetic Biology, Genopole, CNRS, Université d'Evry Val d'Essonne, Evry, France).

19. Transgenic Xenopus laevis as an experimental tool for amphibian regeneration study.

Yoko Ueda (Nara Women's University, Nara, Japan).

20. The Xenopus model for regeneration research. Jonathan MW Slack (Centre for Regenerative Medicine, University of Bath, Bath, BA2 7AY, United Kingdom and Stem and Cell Institute, University of Minnesota, MN, USA).