Zebrafish Neurobehavioral Protocols

by Kalueff, Allan V.; Cachat, Jonathan M.

• ISBN13: 9781607619529
• ISBN10: 1607619520
• Format: Hardcover
• Copyright: 2010-10-01
• Publisher: Humana Pr Inc

Summary

As a model organism, zebrafish (Danio rerio) offer an opportunity to perform steadfast scientific investigations in a robust and high-throughput manner. In Zebrafish Neurobehavioral Protocols, experts in the field provide a series of detailed behavioral protocols dealing with the major current research areas in the field of behavioral neuroscience. The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. This "how to" book will be a useful practical guide for zebrafish researchers and will complement another related book from this series, Zebrafish Models in Neurobehavioral Research. Cutting-edge and timely, Zebrafish Neurobehavioral Protocols serves as an excellent compilation epitomizing the growing potential of zebrafish in modern scientific inquiry.

Table of Contents

Preface to the Series	p. v
Preface	p. vii
Contributors	p. xi
Video-Aided Analysis of Zebrafish Locomotion and Anxiety-Related Behavioral Responses	p. 1
Videograms: A Method for Repeatable Unbiased Quantitative Behavioral Analysis Without Scoring or Tracking	p. 15
Automated Imaging of Avoidance Behavior in Larval Zebrafish	p. 35
Quantifying Anti-predator Responses to Chemical Alarm Cues	p. 49
Modified Associative Learning T-Maze Test for Zebrafish (Danio rerio) and Other Small Teleost Fish	p. 61
Zebrafish Conditioned Place Preference Models of Drug Reinforcement and Relapse to Drug Seeking	p. 75
A Simple and Effective Method to Condition Olfactory Behaviors in Groups of Zebrafish	p. 85
Aquatic Light/Dark Plus Maze Novel Environment for Assessing Anxious Versus Exploratory Behavior in Zebrafish (Danio rerio) and Other Small Teleost Fish	p. 99
A Novel Test Battery to Assess Drug-Induced Changes in Zebrafish Social Behavior	p. 109
Measuring Agonistic Behavior in Zebrafish	p. 125
Measuring Endocrine (Cortisol) Responses of Zebrafish to Stress	p. 135
Phenotyping of Zebrafish Homebase Behaviors in Novelty-Based Tests	p. 143
Neurophenotyping of Adult Zebrafish Using the Light/Dark Box Paradigm	p. 157
Intraperitoneal Injection as a Method of Psychotropic Drug Delivery in Adult Zebrafish	p. 169
Assessing the Maximum Predictive Validity for Neuropharmacological Anxiety Screening Assays Using Zebrafish	p. 181
Deconstructing Adult Zebrafish Behavior with Swim Trace Visualizations	p. 191
Index	p. 203
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