Bioarrays

by Appasani, Krishnarao; Southern, Edwin M., Ph.D.

• ISBN13: 9781588294760
• ISBN10: 1588294765
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-06-27
• Publisher: Humana Pr Inc

Summary

Bioarrays: From Basics to Diagnostics provides an integrated and comprehensive collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. The entire volume is broken into four sections a?? Bioarray Technology Platforms, Biomarkers and Clinical Genomics, Biomarker Identification Using Clinical Proteomics and Glycomics, and Emerging Technologies in Diagnostics a?? that create one well-integrated work. Particular emphasis is placed on DNA, protein, and carbohydrate biochips. The volume also looks extensively at oligonucleotides, cDNA, proteins, antibodies, and carbohydrate arrays. Bioarrays: From Basics to Diagnostics will serve as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.

Table of Contents

Foreword	p. vii
Preface	p. ix
Contributors	p. xv
Bioarray Technology Platforms
Investigation of Tumor Metastasis by Using cDNA Microarrays	p. 3
From Tissue Samples to Tumor Markers	p. 17
Experimental Design for Gene Expression Analysis: Answers Are Easy, Is Asking the Right Question Difficult?	p. 29
From Microarrays to Gene Networks	p. 45
Biomarkers and Clinical Genomics
Reduction in Sample Heterogeneity Leads to Increased Microarray Sensitivity	p. 61
Genomics to Identify Biomarkers of Normal Brain Aging	p. 83
Gene Expression Profiling for Biomarker Discovery	p. 95
Array-Based Comparative Genomic Hybridization: Applications in Cancer and Tuberculosis	p. 107
Regional Specialization of Endothelial Cells as Revealed by Genomic Analysis	p. 123
Biomarker Identification by Using Clinical Proteomics and Glycomics
Identification of Target Antigens in CNS Inflammation by Protein Array Technique	p. 137
Differential Protein Expression, Protein Profiles of Human Gliomas, and Clinical Implications	p. 149
Antibody-Based Microarrays: From Focused Assays to Proteome-Scale Analysis	p. 175
Glycoprofiling by DNA Sequencer-Aided Fluorophore-Assisted Carbohydrate Electrophoresis: New Opportunities in Diagnosing and Following Disease	p. 191
High-Throughput Carbohydrate Microarray Technology	p. 201
Emerging Technologies in Diagnostics
Microarrays and Blood Diagnostics	p. 215
"Lab-On-A-Chip" Devices for Cellular Arrays Based on Dielectrophoresis	p. 231
Genetic Disorders and Approaches to Their Prevention	p. 245
Index	p. 263
Table of Contents provided by Ingram. All Rights Reserved.