9780123003300

Development of the Nervous System

by ; ;
  • ISBN13:

    9780123003300

  • ISBN10:

    012300330X

  • Format: Hardcover
  • Copyright: 2000-04-01
  • Publisher: Academic Pr
  • View Upgraded Edition

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

Purchase Benefits

  • Free Shipping Icon Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • eCampus.com Logo Get Rewarded for Ordering Your Textbooks! Enroll Now
  • Complimentary 7-Day eTextbook Access - Read more
    When you rent or buy this book, you will receive complimentary 7-day online access to the eTextbook version from your PC, Mac, tablet, or smartphone. Feature not included on Marketplace Items.
List Price: $109.00 Save up to $27.25
  • Buy Used
    $81.75
    Add to Cart Free Shipping Icon Free Shipping

    USUALLY SHIPS IN 2-4 BUSINESS DAYS

    7-Day eTextbook Access 7-Day eTextbook Access

Supplemental Materials

What is included with this book?

Summary

Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time.

Table of Contents

Preface xiii
Induction
Development and Evolution of Neurons
1(2)
Early Embryology of Metazoans
3(1)
Neural Tissue Is Derived from Ectoderm
3(9)
Interactions with Neighboring Tissues Are Required for the Ectoderm to Make Neural Tissue in Many Animals
12(15)
Interactions among the Ectodermal Cells Control Neuroblast Segregation
27(9)
Polarity and Regionalization
Regional Identity of the Nervous System
36(2)
The Anterior--Posterior Axis and Hox Genes
38(4)
Hox Gene Function
42(5)
Signaling Molecules that Pattern the Anterior--Posterior Axis in Vertebrates
47(2)
Organizing Centers in the Developing Brain
49(3)
Forebrain Development, Prosomeres, and Pax Genes
52(4)
Dorsal--Ventral Polarity in the Neural Tube
56(1)
Molecular Basis of Dorsal--Ventral Polarity
57(4)
Dorsal Neural Tube and Neural Crest
61(15)
Birth and Migration
Cell Cycle Genes Control the Number of Neurons Generated during Development
76(3)
Cell Interactions Control the Number of Neurons and Glia Generated
79(2)
Cerebral Cortex Histogenesis
81(9)
The Subventricular Zone: A Secondary Zone of Neurogenesis
90(2)
Cerebellar Cortex Histogenesis
92(8)
Postembryonic and Adult Neurogenesis
100(6)
Determination and Differentiation
Transcriptional Control of Invariant Lineages
106(2)
Position and Determination
108(4)
Multiple Interactions in a Lineage-Based System with Asymmetric Cell Division
112(2)
The Dominance of Cellular Interactions in the Determination of Drosophila Retinal Cells
114(3)
Vertebrate Retinogenesis Has a Similar Developmental Strategy
117(6)
Glial Cell Fate
123(2)
Fate Decisions in the Vertebrate Neural Crest
125(5)
Neuronal Fate in the Vertebrate Spinal Cord
130(2)
Laminar Fate in the Cerebral Cortex
132(3)
Positional Cues Determine Axonal Projection Patterns
135(3)
Regulation of Phenotype by the Target
138(4)
Conclusions
142(3)
Axon Growth and Guidance
Axonal Navigation
145(4)
The Growth Cone
149(10)
The Growing Zone
159(2)
The Dynamic Cytoskeleton
161(8)
Growth Cone Guidance
169(1)
Mechanical Guidance
169(2)
Adhesive Guidance
171(1)
Extracellular Matrix and Axon Outgrowth
172(3)
Cell Adhesion Molecules
175(6)
Labeled Pathways and Global Guidance
181(4)
Gradients of Diffusible Tropic Factors
185(4)
Repulsive Factors
189(8)
Axon Regeneration
197(1)
Stop Factors
198(1)
Signal Transduction
199(2)
Summary
201(2)
Target Selection
Cellular Target Recognition
203(3)
Multicellular Targets
206(3)
Secondary Targets
209(1)
Targeting to the Correct Layer
209(3)
Topographic Mapping
212(2)
Mapping the Body
214(7)
Somatotopy: Maps in the Brain and Their Modification
221(3)
Visual Maps and the Theory of Chemospecificity
224(4)
Determination of Retinotopic Identity
228(10)
Shifting Connections, Fine Tuning, and Registration
238(2)
Olfactory Maps
240(4)
Computational Maps
244(3)
Summary
247(1)
Survival and Growth
What Does Neuron Death Look Like?
248(2)
How Many Neurons Die?
250(3)
Survival Depends on the Synaptic Target
253(3)
NGF: A Target-Derived Survival Factor
256(4)
NGF Is a Member of the Neurotrophin Family
260(1)
There Is a Family of Neurotrophin Receptors
260(4)
The Low-Affinity Neurotrophin Receptor
264(2)
The Expanding World of Survival Factors
266(2)
Endocrine Control of Cell Survival
268(2)
Cell Death Requires Protein Synthesis
270(1)
Intracellular Signaling
271(6)
Caspases: Agents of Death
277(2)
Regulating Death Proteins
279(1)
Synaptic Transmission at the Target
279(2)
Afferent Regulation of Cell Survival
281(5)
Summary
286(3)
Synapse Formation and Electric Function
Synaptogenesis
289(1)
What Does Synapse Formation Look Like?
289(4)
Where Do Synaptic Specializations Form?
293(2)
Initial Signs of Synaptogenesis in Vitro
295(1)
Role of Calcium during Presynaptic Differentiation
295(4)
Second Messengers Mediate Presynaptic Differentiation
299(2)
Molecular Signals and Presynaptic Differentiation
301(1)
Receptor Clustering Signifies Postsynaptic Differentiation at NMJ
302(5)
Presynaptic Terminals Induce Receptor Aggregation
307(2)
Agrin, a Transynaptic Clustering Signal
309(1)
Postsynaptic Response to Agrin
309(5)
Receptor Clustering Mechanisms in the CNS
314(4)
Regulation of Receptor Expression and Synthesis
318(3)
Neuronal Activity Limits Receptor Expression
321(1)
ARIA, a Transynaptic Regulator of Transcription
321(3)
Synaptic Transmission
324(1)
Rapid Modulation of Release and Receptor Function
324(4)
Maturation of Transmission and Receptor Isoform Transitions
328(4)
Maturation of Transmitter Reuptake
332(3)
Appearance of Synaptic Inhibition
335(1)
Is Inhibition Really Inhibitory during Development?
335(2)
Electrical Properties
337(1)
Resting Potential and Membrane Properties
337(3)
The Action Potential
340(1)
Channel Diversity
340(2)
Significance of Calcium Channel Expression
342(1)
Regulation of Ionic Channel Expression
343(4)
Summary
347(3)
Refinement of Synaptic Connections
Rearranging Synaptic Connections
350(1)
Functional Synapses Are Eliminated
351(3)
Axonal Arbors Are Refined or Eliminated
354(6)
Some Terminals Expand or Remain Stable
360(1)
Neural Activity Regulates Synaptic Connections
360(11)
Sensory Coding Properties Reflect Synapse Rearrangement
371(4)
Activity Contributes to the Alignment of Sensory Maps
375(3)
Spontaneous Activity and Afferent Segregation
378(1)
Some Forms of Plasticity Have a Time Limit
379(3)
Cellular Events during Synapse Elimination
382(1)
Synapses Interact over a Short Distance
382(2)
Effect of Disuse
384(2)
Heterosynaptic Depression
386(1)
Postsynaptic Receptors Are Eliminated
387(2)
Involvement of Intracellular Calcium
389(3)
NMDA Receptors and Calcium Signaling
392(2)
The Role of Second Messenger Systems
394(2)
Metabotropic Receptors: The Plot Broadens
396(1)
Gain Control
396(3)
Silent Synapses
399(1)
Plasticity of Inhibitory Connections
400(1)
Synaptic Influence on Neuron Morphology
401(2)
Conclusions
403(1)
Behavioral Development
Behavioral Ontogeny
404(1)
Cellular and Environmental Mechanisms
405(2)
Environmental Determinants of Behavioral Development
407(1)
Motor Behavior: The First Movements
408(1)
Are the First Behaviors Spontaneous or Reflexive?
408(2)
The Mechanism of Spontaneous Movements
410(1)
Embryonic Movements: Uncoordinated or Integrated?
410(4)
The Role of Activity in the Emergence of Coordinated Behavior
414(2)
Embryo-Specific Behaviors
416(3)
Motor Learning
419(2)
Beginning to Make Sense of the World
421(2)
Asking Babies Questions
423(1)
Sharp Eyesight
423(3)
Acute Hearing
426(4)
Sex-Specific Behavior
430(1)
Genetic Sex
431(1)
Hormonal Signals
431(1)
Hormonal Control of Brain Gender
432(2)
Genetic Control of Brain Gender
434(2)
Singing in the Brain
436(1)
From Gonads to Brain?
436(1)
Learning to Remember
437(2)
Where's Mamma?
439(1)
Fear and Loathing
440(2)
Complex Tasks
442(3)
Getting Information from One Brain to Another
445(1)
Language
446(4)
Summary
450(3)
References 453(38)
Index 491

Rewards Program

Reviews for Development of the Nervous System (9780123003300)