Diseases of the Breast

by Harris, Jay R.; Lippman, Marc E.; Morrow, Monica; Hellman, Samuel

• ISBN13: 9780397514700
• ISBN10: 0397514700
• Format: Hardcover
• Copyright: 1996-01-01
• Publisher: Lippincott Williams & Wilkins

Summary

Completely revised and updated, with 24 brand-new chapters, the Third Edition of this definitive reference is a must for all clinicians who treat benign or malignant breast diseases. This edition features two new sections on pathology, biological markers, and staging of breast cancer and adjuvant systemic therapy of primary breast cancer. Other new chapters cover imaging, pathogenesis of breast cancer, special therapeutic problems, and breast cancer in young women. Treatment-oriented chapters have been reorganized for greater depth of coverage. An up-to-the-minute "late-breaking" page has been added to many chapters just before publication. This edition also includes new full-color pathology illustrations.

Table of Contents

Contributing Authors	p. xi
Preface	p. xix
Breast Anatomy and Development	p. 1
Breast Anatomy and Development	p. 3
Molecular Mechanisms Regulating Breast Development	p. 15
Diagnosis and Management of Benign Breast Diseases	p. 27
Physical Examination of the Breast	p. 29
Management of the Palpable Breast Mass	p. 33
Management of Disorders of the Ductal System and Infections	p. 47
Management of Breast Pain	p. 57
Abnormalities of the Breast in Pregnancy and Lactation	p. 63
Management of Gynecomastia	p. 69
Pathology of Benign Breast Disorders	p. 77
Breast Imaging and Image-Guided Biopsy Techniques	p. 101
Screening for Breast Cancer	p. 103
Imaging Analysis: Mammography	p. 131
Imaging Analysis: Ultrasonographic Imaging	p. 149
Imaging Analysis: Magnetic Resonance Imaging	p. 165
Imaging: New Techniques	p. 181
Image-Guided Biopsy of Nonpalpable Breast Lesions	p. 199
Epidemiology and Assessing and Managing Risk	p. 221
Nongenetic Factors in the Causation of Breast Cancer	p. 223
Inherited Genetic Factors and Breast Cancer	p. 277
Newer Techniques of Risk Assessment	p. 303
Evaluation and Management of Women with a Strong Family History	p. 315
Chemoprevention of Breast Cancer: Laboratory Principles	p. 347
Chemoprevention: Clinical Aspects	p. 363
Pathogenesis of Breast Cancer	p. 381
Genomic Events in Breast Cancer Progression	p. 383
Targeted Therapeutics in Breast Cancer: Challenges to Success	p. 397
Alterations in the ErbB Signaling Network in Breast Cancer	p. 415
The Role of Proteomic Analyses in Breast Cancer	p. 427
Microarray Analysis of Human Breast Cancer	p. 433
The Biology of Breast Tumor Angiogenesis	p. 441
Control of Invasion and Metastasis	p. 459
The Bcl-2 Family Proteins, Apoptosis, and Breast Cancer	p. 473
In Situ Carcinoma	p. 487
Lobular Carcinoma In Situ: Biology and Pathology	p. 489
Lobular Carcinoma In Situ: Clinical Management	p. 497
Biologic Features of Human Premalignant Breast Disease	p. 507
Ductal Carcinoma In Situ and Microinvasive Carcinoma	p. 521
Pathology, Markers, and Staging of Invasive Breast Cancer	p. 539
Pathology of Invasive Breast Cancer	p. 541
The Biology of Estrogen Receptors	p. 585
Clinical Aspects of Estrogen and Progesterone Receptors	p. 603
Impact of Her-2/Neu Expression on Natural History and Outcome of Human Breast Cancer	p. 619
Staging of Breast Cancer	p. 653
Evaluation of Patients for Metastasis Prior to Primary Therapy	p. 669
Prognostic and Predictive Markers	p. 675
Bone Marrow Micrometastases and Circulating Tumor Cells	p. 697
Lymph Node Micrometastases	p. 709
Local Treatment of Primary Invasive Breast Cancer	p. 717
Local Management of Invasive Cancer: Breast	p. 719
Local Management of Invasive Breast Cancer: Axilla	p. 745
Postmastectomy Radiation Therapy	p. 785
Breast Reconstruction	p. 801
Techniques in Surgery: Lumpectomy for Palpable and Nonpalpable Cancer	p. 819
Techniques in Surgery: Sentinel Node Biopsy and Axillary Dissection	p. 827
Techniques in Surgery: Therapeutic and Prophylactic Mastectomy	p. 835
Techniques in Surgery: Prophylactic Oophorectomy	p. 845
Techniques in Radiation Therapy After Lumpectomy	p. 849
Management Summary on Local Therapy	p. 861
Adjuvant Systemic Therapy of Primary Breast Cancer	p. 863
Adjuvant Endocrine Therapy	p. 865
Adjuvant Chemotherapy and Chemoendocrine Therapy	p. 893
Bone Metastases from Breast Cancer: The Role of Bisphosphonates in Prevention	p. 921
Preoperative Therapy for Operable Breast Cancer	p. 929
Adjuvant Systemic Therapy Treatment Guidelines	p. 945
Special Therapeutic Problems	p. 949
Locally Advanced Breast Cancer	p. 951
Inflammatory Breast Cancer	p. 971
Male Breast Cancer	p. 983
Phyllodes Tumors	p. 991
Paget's Disease	p. 1007
Rare Cancers in the Breast	p. 1015
Pregnancy-Associated Breast Cancer and Subsequent Pregnancy in Breast Cancer Survivors	p. 1035
Occult Primary Cancer with Axillary Metastases	p. 1047
Evaluation After Primary Therapy and Management of Recurrent Breast Cancer	p. 1053
Evaluation of Patients after Primary Therapy	p. 1055
Local-Regional Recurrence after Breast Conservation Treatment or Mastectomy	p. 1067
Treatment of Metastatic Breast Cancer: The Role of Herceptin	p. 1089
Treatment of Metastatic Breast Cancer	p. 1101
New Breast Cancer Therapeutic Approaches	p. 1161
Angiogenesis Inhibition in Breast Cancer	p. 1163
Immunology and Immunotherapy	p. 1169
Tyrosine Kinase Inhibitors	p. 1187
Site-Specific Therapy of Metastatic Breast Cancer	p. 1203
Brain Metastases	p. 1205
Epidural Metastases	p. 1219
Leptomeningeal Metastases	p. 1231
Brachial Plexopathy in Patients with Breast Cancer	p. 1241
Ocular Metastases	p. 1257
Malignant Effusions	p. 1261
Management of Discrete Pulmonary Nodules	p. 1273
Management of Isolated Liver Metastases	p. 1279
Biology of Bone Metastases	p. 1285
Bisphosphonates and Other Medical Treatment of Bone Metastases	p. 1297
Local Treatment of Bone Metastases	p. 1307
Breast Cancer in Special Populations	p. 1321
Breast Cancer in Older Women	p. 1323
Breast Cancer in Young Women	p. 1339
Breast Cancer in Minority Women	p. 1351
End-of-Life Considerations in Patients with Breast Cancer	p. 1365
Issues in Breast Cancer Survivorship	p. 1385
Nursing Care in Patient Management and Quality of Life	p. 1387
Preserving and Restoring Function in Breast Cancer Survivors	p. 1405
Issues in Breast Cancer Survivorship	p. 1419
Lymphedema	p. 1453
Management of Menopausal Problems in Breast Cancer Survivors	p. 1465
Reproductive Health in Breast Cancer Patients	p. 1481
Other Considerations	p. 1491
Medical Legal Aspects of Breast Cancer Evaluation and Management	p. 1493
Cost and Cost-Effectiveness Considerations	p. 1497
Recent and Ongoing Randomized Trials of Adjuvant Therapy for Breast Cancer, Classified by Research Organization	p. 1515
Index	p. 1533
Table of Contents provided by Rittenhouse. All Rights Reserved.