Handbook of Basic Pharmacokinetics... Including Clinical Applications

by Ritschel, Wolfgang A.; Kearns, Gregory L., Ph.D.

• ISBN13: 9780917330735
• ISBN10: 0917330730
• Format: Paperback
• Copyright: 1999-01-01
• Publisher: MCG

Summary

The classic textbook of principles and techniques for practitioners, researchers, and undergraduate and graduate students involved in various applications of pharmacokinetics. Spanning 38 detailed chapters and an appendix providing pharmacokinetic data profiles on more than 420 drugs, this book includes information that is both current and accurate. Presented in a manner that fosters clinical application, readers will gain an understanding of the more precise equations for determining pharmacokinetic values.

Author Biography

Gregory L. Kearns is Marion Merrell Dow/Missouri Chair in Pediatric Pharmacology and Professor of Pediatrics and Pharmacology at the University of Missouri-Kansas City. He is also Chief, Division of Pediatric Pharmacology and Medical Toxicology and Director, Pediatric Pharmacology Research Unit, at Children's Mercy Hospitals and Clinics in Kansas City, Missouri

Table of Contents

Preface

1. Definitions and Glossary

2. The LADMER System¿Liberation, Absorption, Distribution, Metabolism, Elimination, and Response

3. Organs, Tissues, Cells, and Organelles

4. Cell Membranes

5. Drug–Receptor Interactions

6. Absorption/Transport Mechanisms

7. pKa and Degree of Ionization

8. Lipid/Water Partition Coefficient

9. Physicochemical Factors Altering Biological Performance of Drugs

10. Biopharmaceutical Data of the Gastrointestinal Tract

11. Fluid Compartments and Circulatory System

12. Binding of Drugs to Biological Material

13. Drug Biotransformation

14. Compartment Models

15. Determination of Rate Constants

16. Volume of Distribution and Distribution Coefficient

17. Excretion and Clearance of Drugs

18. Urinary and Biliary Recycling

19. Cumulative Urinary Excretion

20. Area Under the Blood Level–Time Curve

21. Pharmacokinetics of Single Dose Administration

22. Pharmacokinetics of Multiple Dosing

23. Compartment Model Independent Analysis

24. Pediatric Pharmacokinetics

25. Drug Dosage in Elderly Patients

26. Drug Dosage in Obese Patients

27. Drug Disposition in Pregnancy

28. Dosage Regimen Design

29. Drug Monitoring and Dose Adjustment

30. Physiological and Pathological Factors

31. First Dose Size in Man

32. Forensic Pharmacokinetics

33. Nonlinear Pharmacokinetics

34. Curve Fitting

35. Correlation of Clinical Response with Drug Disposition

36. Bioavailability and Bioequivalence

37. Body Surface Areas

38. Extracorporeal Methods of Drug Removal

Appendix

Index