Hypertension Primer : The Essentials of High Blood Pressure

by Izzo, Joseph L.; Black, Henry R.; Council on High Blood Pressure Research, American Heart Association

• ISBN13: 9780683307061
• ISBN10: 0683307061
• Edition: 2nd
• Format: Paperback
• Copyright: 1999-05-01
• Publisher: Lippincott Williams & Wilkins

Summary

Now in its thoroughly updated Third Edition, the Hypertension Primer is a comprehensive, readable source of state-of-the-art scientific and clinical information on hypertension. The book contains more than 150 short chapters by distinguished experts that cover every aspect of hypertension and its pathogenesis, epidemiology, impact, and management. The chapters are grouped into three well-organized sections--basic science, population science, and clinical management--and each chapter is cross-referenced to other relevant chapters. Each chapter is easily digestible and begins with a bulleted list of key points.

Table of Contents

Part A: BASIC SCIENCE
Vasoactive Substances
Adrenergic and Dopaminergic Receptors and Actions	3	(4)
Kathleen H. Berecek
Robert M. Carey
Catecholamine Synthesis, Release, Reuptake and Metabolism	7	(4)
Richard Weinshilboum
Angiotensins: Actions and Receptors	11	(3)
Theodore L. Goodfriend
Angiotensinogen	14	(2)
Morton P. Printz
Renin Synthesis and Release	16	(3)
William H. Beierwaltes
Angiotensin I-Converting Enzyme	19	(2)
Randal A. Skidgel
Ervin G. Erdos
Angiotensin Formation and Degradation	21	(2)
Carlos M. Ferrario
Tissue Renin-Angiotensin Systems	23	(2)
M. Ian Phillips
Mineralocorticoid Receptors and Actions	25	(1)
David J. Morris
Charles O. Watlington
Aldosterone and Other Mineralocorticoid Synthesis and Regulation	26	(2)
Celso E. Gomez-Sanchez
Cardiovascular Effects of Sex Steroids	28	(2)
David C. Kem
Prostaglandins and P450 Metabolites	30	(3)
John C. McGiff
Alberto Nasjletti
Lipoxygenase Products	33	(2)
Jerry L. Nadler
Cardiovascular Effects of Fatty Acids	35	(1)
Brent M. Egan
Endothelin	36	(2)
Ernesto L. Schiffrin
Vasopressin and Neuropeptide Y	38	(2)
Allen W. Cowley
Kinins	40	(2)
Oscar A. Carretero
Endogenous Natriuretic Peptides	42	(2)
John C. Burnett
Yorman Shenker
Nitric Oxide	44	(3)
Ferid Murad
R. Clinton Webb
Acetylcholine, GABA, Serotonin, Adenosine, and Endogenous Quabain	47	(3)
Roger J. Grekin
John M. Hamlyn
Adrenomedullin-Derived Peptides and CGRP	50	(1)
Willis K. Samson
Cell Physiology
Membrane Sodium Transport	51	(2)
Alan B. Weder
Intracellular pH and Cell Volume	53	(3)
Bradford C. Berk
Cellular Potassium Transport	56	(2)
Jason Xiao-Jian Yuan
Mordecai P. Blaustein
Calcium Transport and Calmodulin	58	(3)
David J. Triggle
Signal Transduction: Receptors	61	(2)
Greti Aguilera
Signal Transduction: Guanine Nucleotide Binding Proteins	63	(3)
James C. Garrison
Signal Transduction: Cyclic Nucleotides	66	(3)
Kevin J. Catt
Tamas Balla
Signal Transduction: Inositol Phosphates	69	(2)
Kevin J. Catt
Tamas Balla
Signal Transduction: Protein Phosphorylation	71	(5)
George W. Booz
Kenneth M. Baker
Adhesion Molecules	76	(2)
Willa A. Hsueh
Vascular Smooth Muscle Contraction and Relaxation	78	(2)
Anna F. Dominiczak
David F. Bohr
Vasoregulatory Systems
Functional Neuroanatomy of Central Vasomotor Control Centers	80	(3)
Donald J. Reis
Arterial Baroreflexes	83	(4)
Mark W. Chapleau
Cardiopulmonary Baroreflexes	87	(2)
Pramod K. Mohanty
Renal Nerves and ECF Volume Regulation	89	(3)
Jeffrey L. Osborn
Suzanne G. Greenberg
Systemic Hemodynamics and Regional Blood Flow Regulation	92	(3)
Thomas G. Coleman
John E. Hall
Autoregulation of Blood Flow	95	(3)
Richard J. Roman
Pathophysiology of Essential Hypertension
Monogenic Determinants of Blood Pressure: Adrenal Steroid Disorders	98	(3)
Robert G. Dluhy
Polygenic Determinants of Blood Pressure	101	(3)
George T. Cicila
Renin-Angiotensin Genetics	104	(2)
James R. Sowers
Sympathetic Nervous System Abnormalities in Hypertension	106	(3)
J. Michael Wyss
The Sympathetic Nervous System in Human Hypertension	109	(4)
Joseph L. Izzo
Hyperkinetic Hypertension and Vascular Hyperresponsiveness	113	(2)
Mark A. Creager
Marie D. Gerhard
Hemodynamic Profiles and Responses	115	(3)
Fetnat Found-Tarazi
Joseph L. Izzo
Obesity	118	(3)
Lewis Landsberg
Insulin Resistance and Hypertension	121	(2)
Helmut O. Steinberg
Salt Sensitivity	123	(2)
Myron H. Weinberger
Divalent Cations in Essential Hypertension	125	(3)
Lawrence M. Resnick
Experimental Models of Hypertension	128	(3)
Donald J. DiPette
Pathophysiology of Secondary Hypertension
Pathophysiology of Renovascular Hypertension	131	(4)
Luis Gabriel Navar
David W. Ploth
Pathophysiology of Renal Parenchymal Hypertension	135	(3)
Vito M. Campese
Pathophysiology of Adrenal Cortical Hypertension	138	(3)
Burl R. Don
Morris Schambelan
Pathophysiology of Pheochromocytoma	141	(2)
William M. Manger
HTN Caused by Thyroids and Parathyroid Abnormalities and Acromegaly	143	(3)
Yoram Shenker, MD
Coarctation of the Aorta	146	(2)
Albert P. Rocchini
Pathophysiology of Sleep Apnea	148	(2)
Barbara J. Morgan
Affective Illness and Hypertension	150	(2)
Wayne L. Creelman
Pathophysiology of Preeclampsia	152	(3)
Ellen W. Seely
Marshall D. Lindheimer
Hypertension and Transplantation	155	(2)
Stephen C. Textor
Mechanisms of Target Organ Damage
Mechanisms of Vascular Hypertrophy	157	(3)
Paul R. Standley
Arterial Stiffness and Hypertension	160	(3)
Michael F. O'Rourke
Oxidative Stress and Hypertension	163	(4)
David G. Harrison
Zorina Galis
Sampath Parthasarathy
Kathy K. Griendling
Endothelial Dysfunction	167	(3)
James R. Sowers
Joseph L. Izzo
Atherogenesis	170	(3)
John P. Cooke
Microvascular Regulation and Dysregulation	173	(2)
Andrew S. Greene
Sequelae of Hypertension
Pathogenesis of Coronary Artery Disease	175	(2)
Charles K. Francis
Pathogensis of Left Ventricular Hypertrophy and Diastolic Dysfunction	177	(3)
Joseph L. Izzo
Pathogenesis of Congestive Heart Failure	180	(3)
Edmund H. Sonnenblick
Thierry H. LeJemtel
Pathogenesis of Stroke	183	(3)
Patrick Pullicino
Pathogenesis of Acute Hypertensive Encephalopathy	186	(2)
Donald D. Heistad
William J. Lawton
Pathogenesis of Vascular Disease and Mixed Dementia	188	(2)
Linda A. Hershey
Pathogenesis of Hypertensive Renal Damage	190	(4)
Sharon Anderson
The Eye in Hypertension	194	(5)
Robert N. Frank
Part B: POPULATION SCIENCE
Cardiovascular Risk and Hypertension
Cardiovascular Risk Factors and Hypertension	199	(4)
William B. Kannel
Peter W.F. Wilson
Cerebrovascular Risk	203	(5)
Philip A. Wolf
Left Vertricular Hypertrophy Prognosis	208	(3)
Daniel Levy
Renal Risk	211	(4)
Michael J. Klag
Peripheral Arterial Disease and Hypertension	215	(3)
Michael H. Criqui
Julie O. Denenberg
Robert D. Langer
Arnost Fronek
Gloria Bensussen
Genetics and Family History of Hypertension	218	(4)
Steven C. Hunt
Roger R. Williams
Gene-Enviroment Interactions	222	(2)
Anne E. Kwitek-Black
Howard J. Jacob
Impact of Hypertension: Globally and Special Populations
Geographic Patterns of Hypertension: A Global Perspective	224	(2)
Richard S. Cooper
Geographic Patterns of Hypertension in the United States	226	(3)
W. Dallas Hall
Gender and Blood Pressure	229	(4)
David A. Calhoun
Suzanne Oparil
Blood Pressure in Children	233	(3)
Alan R. Sinaiko
The Elderly Patient with Hypertension	236	(3)
William B. Applegate
Ethnicity and Socioeconomic Status in Hypertension	239	(3)
John M. Flack
Beth A. Staffileno
Carla Yunis
Socioeconomic Status and Blood Pressure	242	(2)
Daniel W. Jones
Lifestyle Factors and Blood Pressure
Overall Dietary Patterns and Blood Pressure	244	(3)
Frank M. Sacks
Salt and Blood Pressure	247	(3)
Norman M. Kaplan
Potassium and Blood Pressure	250	(3)
Paul K. Whelton
Calcium, Magnesium, and Blood Pressure	253	(3)
Lawrence J. Appel
Obesity, Body Fat Distribution, and Insulin Resistance: Clinical Relevance	256	(3)
Steven M. Haffner
Physical Activity, Fitness, and Blood Pressure	259	(4)
Denise G. Simons-Morton
Alcohol Use and Blood Pressure	263	(3)
William C. Cushman
Psychosocial Stress and Blood Pressure	266	(2)
Thomas G. Pickering
Prevention and Control
Trends in Blood Pressure Control and Mortality	268	(3)
Thomas J. Thom
Edward J. Roccella
Hypertension: A Worldwide Epidemic	271	(3)
Patrick J. Mulrow
Prevention of Hypertension	274	(5)
Jeffrey A. Cutler
Jeremiah Stamler
Treatment Trials: Morbidity and Mortality	279	(4)
Bruce M. Psaty
Curt D. Furberg
Antihypertensive Treatment Trials: Quality of Life	283	(3)
Richard H. Grimm
Economic Impact of Blood Pressure	286	(3)
William B. Stason
Economic Considerations in the Management of Hypertension	289	(6)
William J. Elliott
Part C: CLINICAL MANAGEMENT
General Diagnostic Aspects
Blood Pressure Measurement	295	(4)
Carlene M. Grim
Clarence E. Grim
Initial Workup of the Hypertensive Patient	299	(3)
Marvin Moser
Out of Office Blood Pressure Monitoring	302	(4)
William B. White
Genetic Profiling in Hypertension	306	(2)
Haralambos Gavras
Evaluation of Target Organs
Neurological Evaluation in Hypertension	308	(3)
Stephen J. Phillips
Irene Meissner
Basic Cardiac Evaluation: Physical Examination, Electrocardiogram, and Chest Radiograph	311	(2)
Clarence Shub
John A. Rumberger
Cardiac Imaging	313	(4)
Clarence Shub
John A. Rumberger
Exercise Stress Testing	317	(3)
Michael F. Wilson
Mofid N. Khalil Ibrahim
Evaluation of Renal Parenchymal Disease	320	(3)
Michael A. Moore
Evaluation of the Peripheral Circulation	323	(4)
Jeffrey W. Olin
Evaluation of Arterial Compliance	327	(3)
Gary E. McVeigh
Evaluation of Aortocarotid Baroreflexes	330	(3)
Addison Taylor
Principles of Management
Approach to Treatment of the Hypertensive Patient	333	(4)
Ray W. Gifford
Treatment Goals in the Hypertensive Patient	337	(2)
Kenneth Jamerson
Lifestyle Modifications	339	(3)
Theodore A. Kotchen
Jane Morley Kotchen
Dose-Response Relationship and Dose Adjustments	342	(3)
Domenic A. Sica
Todd W.B. Gehr
Variability in Individual Responses to Antihypertensive Drugs	345	(3)
Joseph L. Izzo
Adherence to Antihypertensive Therapy	348	(4)
Martha N. Hill
When to Refer Patients for Hypertensive Consultation	352	(2)
Gary L. Schwartz
Managment of Patients with Refractory Hypertension	354	(4)
Henry R. Black
Antihypertensive Drugs
Diuretics	358	(4)
Jules B. Puschett
Beta Adrenergic Blockers	362	(4)
William H. Frishman
Alpha Adrenergic Blockers	366	(2)
Richard H. Grimm
Alpha-Beta Adrenergic Blockers	368	(2)
Mahboob Rahman
Jackson T. Wright
Central and Peripheral Sympatholytics	370	(2)
Barry J. Materson
Angiotensin-Converting Enzyme Inhibitors	372	(5)
Domenic A. Sica
Elizabeth Ripley
Angiotensin II Receptor Blockers	377	(2)
Michael A. Weber
Dihydropyridine Calcium Antagonists	379	(3)
Matthew R. Weir
Non-Dihydropyridine Calcium Antagonists	382	(3)
T. Barry Levine
Domenic A. Sica
Direct Vasodilators	385	(3)
C. Venkata S. Ram
Other Agents: Potassium Channel Openers, Serotonin-Related Agents, Dopamine Agonists, Renin Inhibitors, Imidazolines, Neutral Endopeptidase Inhibitors, and Endothelin-Receptor Antagonists	388	(2)
William J. Elliott
Managing Hypertension (Target Organ Damage)
Management of Orthostatic Hypotension, Hypertension, and Tachycardia	390	(3)
David H.P. Streeten
Management of Baroreflex Failure	393	(3)
David Robertson
Management of Hypertensive Patients with Cerebrovascular Disease	396	(2)
Robert D. Brown
Management of Hypertensive Patients with Ischemic Heart Disease	398	(4)
Jay M. Sullivan
Charles K. Francis
Management of Hypertensive Patients with Left Ventricular Hypertrophy and Diastolic Dysfunction	402	(3)
Edward D. Frohlich
Management of Hypertensive Patients with Dilated Cardiomyopathy (Systolic Dysfunction)	405	(2)
Jay N. Cohn
Management of Hypertensive Patients with Chronic Renal Insufficiency	407	(3)
Marc A. Pohl
Management of Hypertensive Patients with Peripheral Arterial Disease	410	(3)
Jeffrey W. Olin
Management of Special Populations
Management of Minority Patients with Hypertension	413	(2)
Keith C. Ferdinand
Management of the Obese Hypertensive Patient	415	(3)
Efrain Reisen
Management of the Hypertensive Patient with Lipid and Lipoprotein Abnormalities	418	(3)
Michael D. Cressman
Treatment of Hypertensive Patients with Diabetic Nephropathy	421	(3)
George L. Bakris
Management of Hypertensive Children and Adolescents	424	(3)
Bonita Falkner
Management of Pregnant Hypertensive Patients	427	(3)
Phyllis August
Management of Hypertension in Older Persons	430	(3)
Henry R. Black