Foye's Principles of Medicinal Chemistry

by Foye, William O.; Lemke, Thomas L.; Williams, David A.

• ISBN13: 9780683033236
• ISBN10: 0683033239
• Edition: 4th
• Format: Hardcover
• Copyright: 1995-06-01
• Publisher: Lippincott Williams & Wilkins

Summary

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist as therapeutic clinical consultant. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.

Table of Contents

Introduction and History	1	(7)
William O. Foye
Medicinals of Plant Origin: Historical Aspects	7	(5)
William O. Foye
Biopharmaceutical Properties of Drug Substances	12	(13)
Sunil S. Jambhekar
Structural Features and Pharmacologic Activity	25	(25)
Ian W. Mathison
William E. Solomons
Richard R. Tidwell
Theoretic Aspects of Drug Design	50	(8)
Michael S. Tute
Lemont B. Kier
Molecular Modeling	58	(17)
James G. Henkel
Eric M. Billings
Receptors and Drug Action	75	(8)
Timothy J. Maher
Drug Metabolism	83	(58)
David A. Williams
Volatile Anesthetics	141	(13)
Ronald L. Jacoby
Karl A. Nieforth
Central Nervous System Depressants: Sedative-Hypnotics	154	(28)
Julius A. Vida
Anticonvulsants	182	(17)
Julius A. Vida
Neuroleptics and Anxiolytic Agents	199	(33)
John L. Neumeyer
Raymond G. Booth
Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonism Agents and Skeletal Muscle Relaxants	232	(15)
John L. Neumeyer
Raymond G. Booth
Analgesics	247	(23)
David S. Fries
Central Nervous System Stimulants	270	(35)
Karl A. Nieforth
Gerald Gianutsos
Local Anesthetics	305	(16)
Matthias C. Lu
Cholinergic Agonists, Acetylcholinesterase Inhibitors, and Cholinergic Antagonists	321	(24)
Danny L. Lattin
Adrenergic Drugs	345	(21)
Robert K. Griffith
Elizabeth A. Johnson
Cardiac Agents: Cardiac Glycosides, Antianginals, and Antiarrhythmic Drugs	366	(22)
Ahmed S. Mehanna
Anticoagulants, Coagulants, and Plasma Extenders	388	(17)
Richard H. Hammer
Diuretics	405	(11)
Gary O. Rankin
Antiallergic and Antiulcer Drugs	416	(28)
Maria Di Bella
Daniela Braghiroli
Donald T. Witiak
Cholesterol, Adrenocorticoids, and Sex Hormones	444	(55)
Robert W. Brueggemeier
Duane D. Miller
Donald T. Witiak
Antilipidemic Drugs	499	(36)
Dennis R. Feller
Larry M. Hagerman
Howard A. I. Newman
Donald T. Witiak
Nonsteroidal Anti-inflammatory Drugs	535	(46)
Ronald F. Borne
Drugs Affecting Sugar Metabolism	581	(20)
Edmund J. Hengesh
Amino Acids, Peptides, and Proteins	601	(21)
Roy L. Kisliuk
Pharmaceutical Biotechnology	622	(30)
Robert D. Sindelar
Vitamins and Coenzymes	652	(36)
Raymond W. Doskotch
Robert W. Curley, Jr.
Thyroid Function and Thyroid Drugs	688	(17)
Alireza Banijamali
Metabolite Antagonism	705	(25)
Nitya Anand
Parasite Chemotherapy	730	(17)
William O. Foye
Antimycobacterial Agents	747	(12)
Thomas L. Lemke
Antibiotics and Antimicrobial Agents	759	(44)
Lester A. Mitscher
Antifungal Agents	803	(9)
Eugene D. Weinberg
Antiseptics and Disinfectants	812	(10)
Thomas L. Lemke
Cancer Chemotherapy	822	(24)
William O. Foye
Sisir K. Sengupta
Antiviral Agents	846	(16)
Manohar L. Sethi
Approaches to Anti-AIDS Agents	862	(15)
Prem Mohan
Horomone Antagonists	877	(16)
V. Craig Jordan
Photochemotherapy	893	(15)
Francesco Dall'Acqua
Giulio Jori
Pesticides	908	(19)
John L. Neumeyer
Raymond G. Booth
Agents for Organ Imaging	927	(21)
Raymond E. Counsell
Jamey P. Weichert
Appendix PKa Values for Some Drugs and Miscellanous Organic Acids and Bases	948	(15)
pH Values for Tissue Fluids
David A. Williams
Index	963