Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

by Golan, David E.; Armstrong, Ehrin J.; Galanter, Joshua M.; Armstrong, April Wang; Arnaout, Ramy A.; Rose, Harris S.

• ISBN13: 9780781746786
• ISBN10: 0781746787
• Format: Paperback
• Copyright: 2004-04-13
• Publisher: LWW

Summary

Unlike other pharmacology texts organized by drug class, Principles of Pharmacology integrates relevant knowledge from the basic biomedical sciences - physiology, pathophysiology, cell and molecular biology, biochemistry, anatomy, neurobiology, microbiology and immunology - to build an integrated, conceptual understanding of drug therapy. By discussing the therapeutic and adverse actions of drugs in the framework of the drug's mechanism of action, the book enables students to achieve a level of mastery in pharmacology that far surpasses that achieved by rote memorization. The result is a primary pharmacology textbook that is ideal for a systems-based or discipline-based course in pharmacology.

Table of Contents

Foreword	p. vii
Preface	p. ix
Acknowledgments	p. xi
Contributors	p. xiii
Fundamental Principles of Pharmacology	p. 1
Drug-Receptor Interactions	p. 3
Pharmacodynamics	p. 17
Pharmacokinetics	p. 27
Drug Metabolism	p. 45
Principles of Neuropharmacology	p. 55
Fundamental Principles of Neuropharmacology	p. 57
Principles of Cellular Excitability and Electrochemical Transmission	p. 59
Principles of Nervous System Physiology and Pharmacology	p. 71
Principles of Autonomic and Peripheral Nervous System Pharmacology	p. 87
Cholinergic Pharmacology	p. 89
Adrenergic Pharmacology	p. 107
Local Anesthetic Pharmacology	p. 121
Principles of Central Nervous System Pharmacology	p. 137
Pharmacology of Excitatory and Inhibitory Neurotransmission	p. 139
Pharmacology of Dopaminergic Neurotransmission	p. 161
Pharmacology of Affective Disorders	p. 179
Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System	p. 193
General Anesthetic Pharmacology	p. 205
Pharmacology of Analgesia	p. 229
Pharmacology of Chemical Dependence and Addiction	p. 247
Principles of Cardiovascular Pharmacology	p. 265
Pharmacology of Cardiac Rhythm	p. 267
Pharmacology of Cardiac Contractility	p. 285
Pharmacology of Volume Regulation	p. 299
Pharmacology of Vascular Tone	p. 317
Pharmacology of Hemostasis and Thrombosis	p. 335
Pharmacology of Cholesterol and Lipoprotein Metabolism	p. 357
Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Congestive Heart Failure	p. 375
Principles of Endocrine Pharmacology	p. 401
Pharmacology of the Hypothalamus and Pituitary Gland	p. 403
Pharmacology of the Thyroid Gland	p. 415
Pharmacology of the Adrenal Cortex	p. 425
Pharmacology of Reproduction	p. 441
Pharmacology of the Endocrine Pancreas	p. 457
Pharmacology of Bone Mineral Homeostasis	p. 473
Principles of Chemotherapy	p. 491
Principles of Antimicrobial and Antineoplastic Pharmacology	p. 493
Pharmacology of Nucleotide Synthesis	p. 505
Pharmacology of DNA Replication and Mitosis	p. 519
Pharmacology of Transcription and Translation	p. 535
Pharmacology of Viral Replication	p. 545
Pharmacology of the Bacterial Cell Wall	p. 565
Pharmacology of Fungal Infections	p. 579
Pharmacology of Parasitic Infections	p. 587
Principles of Combination Chemotherapy	p. 603
Principles of Inflammation and Immune Pharmacology	p. 615
Principles of Inflammation and the Immune System	p. 617
Pharmacology of Eicosanoids	p. 627
Histamine Pharmacology	p. 647
Pharmacology of Hematopoietic and Immune Cell Stimulation	p. 655
Pharmacology of Immunosuppression	p. 667
Integrative Inflammation Pharmacology: Peptic Ulcer Disease	p. 683
Integrative Inflammation Pharmacology: Asthma	p. 695
Integrative Inflammation Pharmacology: Gout	p. 709
Principles of Toxicology	p. 717
Principles of Toxicology	p. 719
Contemporary Approaches to Drug Discovery, Development and Delivery	p. 745
Drug Discovery and Development	p. 747
Protein-Based and Gene Therapies	p. 757
Drug Delivery Mechanisms	p. 781
Fundamentals of Drug Evaluation and Pharmacogenomics	p. 789
New Drug Evaluation and Drug Regulation	p. 791
Pharmacogenomics	p. 803
Credit List	p. 811
Index	p. 815
Table of Contents provided by Rittenhouse. All Rights Reserved.