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9780896039971

Neural Mechanisms of Anesthesia

by ; ;
  • ISBN13:

    9780896039971

  • ISBN10:

    0896039978

  • Format: Hardcover
  • Copyright: 2002-10-01
  • Publisher: Humana Pr Inc

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Summary

Leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.

Table of Contents

Preface v
Contributors xi
I. Introduction
The Development of Concepts of Mechanisms of Anesthesia
3(10)
Donald Caton
Joseph F. Antognini
II. Anesthesia, Consciousness, and Memory
Mechanisms of Consciousness with Emphasis on the Cerebral Cortical Component
13(8)
G. Bryan Young
Anesthesia Meets Memory: Tools for Critical Appraisal
21(44)
Robert A. Veselis
III. Sleep, Coma, and Anesthesia-Similarities and Differences
Sleep and Anesthesia
65(10)
John Keifer
Possible Relationships of Anesthetic Coma and Pathological Disorders of Consciousness
75(18)
Nicholas D. Schiff
Fred Plum
IV. Neural Mechanisms
Cerebral Cortex-Anesthetic Action on the Electroencephalogram: Cellular and Synaptic Mechanisms and Clinical Monitoring
93(20)
Heath Lukatch
Scott Greenwald
Cerebral Mechanisms of Analgesia and Anesthesia in Humans Elucidated by In Vivo Brain Imaging
113(12)
Ferenc Gyulai
Leonard Firestone
Thalamus
125(24)
Anthony Angel
The Hippocampus
149(20)
M. Bruce MacIver
Anesthetic Effects on the Reticular Formation, Brainstem and Central Nervous System Arousal
169(14)
Joseph F. Antognini
Earl Carstens
Anesthesia, the Spinal Cord and Motor Responses to Noxious Stimulation
183(22)
Joseph F. Antognini
Earl Carstens
Spinal Cord-Dorsal Horn
205(10)
J. G. Collins
Spinal Cord: Anesthetic Actions on Motor Neurons
215(16)
Joan J. Kendig
Simple Genetic Models for Anesthetic Action
231(18)
Philip G. Morgan
Margaret Sedensky
Genetic Dissection of Anesthetic Action
249(16)
Gregg E. Homanics
Leonard L. Firestone
V. Cellular and Molecular Mechanisms
General Anesthetic Effects on GABAA Receptors
265(18)
Robert A. Pearce
Nicotinic Acetylcholine Receptors and Anesthetics
283(16)
Stuart A. Forman
Pameta Flood
Douglas Raines
Actions of General Anesthetic on Voltage-Gated Ion Channels
299(20)
Norbert Topf
Esperanza Recio-Pinto
Thomas J. J. Blanck
Hugh C. Hemmings, Jr.
Glutamate Receptors: Physiology and Anesthetic Pharmacology
319(14)
Misha Perouansky
Joseph F. Antognini
General Anesthetic Effects on Glycine Receptors
333(12)
Stephen Daniels
Presynaptic Actions of General Anesthetics
345(26)
Misha Perouansky
Hugh C. Hemmings, Jr.
The Meyer-Overton Relationship and Its Exceptions
371(24)
Warren S. Sandberg
Keith W. Miller
Protein Models
395(18)
Jonas S. Johansson
Roderic G. Eckenhoff
The Opioid Receptors
413(14)
Gary J. Brenner
Jianren Mao
Carl Rosow
Local Anesthetics
427(14)
Ging Kuo Wang
Neuromuscular Blocking Agents and General Anesthesia
441(8)
Gerald A. Gronert
Timothy Tautz
VI. Future Research
The Future of Anesthetic Mechanisms Research
449(6)
Joseph F. Antognini
Douglas E. Raines
Earl Carstens
Index 455

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