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9781847552594

Functional Molecules from Natural Sources

by ; ; ;
  • ISBN13:

    9781847552594

  • ISBN10:

    1847552595

  • Format: Hardcover
  • Copyright: 2010-11-26
  • Publisher: Royal Society of Chemistry

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Summary

Naturally-occurring compounds have been, and continue to be, an important source of new leads and of commercially successful products for various industrial sectors, notably pharmaceuticals and agrochemicals. The last decade has, however, seen many challenges as well as new opportunities for the industrial utilization of molecules from natural sources, including the birth of 'nutraceuticals' and 'cosmeceuticals'. This book is the proceedings of a third successful conference held at Magdalen College, Oxford in July 2009 and highlights current trends, challenges and successes in the exploitation of natural products.

Table of Contents

Modern and Emerging Perspectives on Natural Product Utilisation
Natural Products, Derivatives and Mimics as Antitumour Agents
From Natural Products to Medicinal Chemistryp. 37
Improved Strategies for Natural Product Exploitation
Discovery and Development of Antibiotics with Novel Modes of Actionp. 51
Marine Micro-Organisms: A Source of Novel Bio-Activesp. 71
A Unique Natural Product Platform Applied to the Discovery of Novel Compounds with Activity Against the Malaria Parasite, Plasmodium falciparump. 83
High Capacity Countercurrent Chromatography for Fast Isolation of Natural Productsp. 90
Functional Molecules and Their Enhancement
Strategies to Enhance the Neuroprotective Properties of Rapamycin Analogsp. 101
Pleuromutilins: Antibiotic Optimisation for Humanp. 106
Oxazolomycins and Equisetins: Novel Antibiotic Lead Structuresp. 117
Erucin, an Isothiocyanate from Rocket Salad Species, Enhances the Biological Activity of Transforming Growth Factor-ßp. 124
Advances in Pharmaceutical Applications of Iminosugarsp. 129
Deoxyschizandrin and y-Schizandrin Restore the Cytotoxic Action of Doxorubicin in Multi-Drug Resistant Lung Cancer Cells Cor-L23/Rp. 140
Biosynthesis and Genetics
Elucidation of Pathways for Antibiotic Biosynthesis in Streptomyces coelicolor A3(2)p. 149
Modifying Oxidation and Glycosylation Events in Biosyntheses of Natural Product Anticancer Drugs - Challenges for Combinatorial Biosynthesisp. 161
Studies on the Biosynthesis of the Anthrax Siderophore Petrobactinp. 184
Proposed Quaternary Structure of Type I (Modular) Polyketide Synthasesp. 195
Biosynthesis of Polyenes in Auxarthron umbrinump. 209
Summary of Other Lectures
Functional Molecules from Natural Sources: Summary of Other Lecturesp. 217
Subject Indexp. 225
Table of Contents provided by Ingram. All Rights Reserved.

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