Nanotechnology for Biomedical Imaging and Diagnostics From Nanoparticle Design to Clinical Applications

Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine.

Grouped into three sections, the book:

• Elucidates all major aspects of nanotechnology and bioimaging
• Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine
• Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference
• With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike

Mikhail Y. Berezin, PhD, is an Assistant Professor of Radiology at the Washington University School of Medicine. He earned his M. Sc. in Chemical Engineering and his Ph.D. in Organic Chemistry from the Moscow Institute of Oil and Gas and Institute of Organic Chemistry (Academy of Science), after which he conducted research in optical imaging at Washington University in St. Louis. He is a research member of the Siteman Cancer Center, as well as a member of the American Chemical Society and the Biomedical Optics Society.

Contributors ix

PREFACE xiii

Acknowledgments xix

1 Historical Perspective on Nanoparticles in Imaging from 1895 to 2000 1
Mikhail Y. Berezin

Part I Nanoparticle design, synthesis and characterization 25

2 Iron Oxide-Based Magnetic Nanoparticles Synthesized from the Organic Solution Phase for Advanced Biological Imaging 27
Sen Zhang and Shouheng Sun

3 Lipid-Based Pharmaceutical Nanocarriers for Imaging Applications 49
Tamer Elbayoumi and Vladimir Torchilin

4 Hollow Nanocapsules in Biomedical Imaging Applications 83
Sergey A. Dergunov and Eugene Pinkhassik

5 Nanoparticles as Contrast Agents for Optoacoustic Imaging 111
Anton V. Liopo and Alexander A. Oraevsky

6 Nanoparticles for Bioimaging: Analytical Characterization and Measurements 151
Kate Nelson, Patrick Winter, Monica Shokeen, Steven Wang, and Mikhail Y. Berezin

Part II Imaging modalities: from concepts to applications 193

7 Radio-Labeled Nanoparticles for Biomedical Imaging 195
Tolulope Aweda, Deborah Sultan, and Yongjian Liu

8 MRI with Gadolinium-Based Nanoparticles 223
François Guérard, Geoffrey L. Ray, and Martin W. Brechbiel

9 In Vivo Molecular Fluorescence Imaging 263
Yasaman Ardeshirpour, Victor Chernomordik, Moinuddin Hassan, Dan Sackett, and Amir H. Gandjbakhche

10 Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents 293
Mansik Jeon and Chulhong Kim

11 Surface-Enhanced Raman Scattering-Based Bioimaging 325
Limei Tian and Srikanth Singamaneni

Part III Nanotechnology in biomedical imaging and beyond 347

12 Pandia®: Gold Nanorods and their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and their Potential Application to Humans 349
Christian Schoen and Cheryl London

13 Imaging Genetic Information 373
John-Stephen Taylor

14 The Application of Plant Viral Nanoparticles in Tissue-Specific Imaging 401
Amy M. Wen, Choi-Fong Cho, John D. Lewis, and Nicole F. Steinmetz

15 Design and Development of Theranostic Nanomedicines 429
Jelena M. Janjic and Mingfeng Bai

16 Animal Models for Preclinical Imaging 467
Grayson Talcott and Walter J. Akers

Index 487

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