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9780192632678

Vascular Cognitive Impairment Preventable Dementia

by ;
  • ISBN13:

    9780192632678

  • ISBN10:

    0192632671

  • Format: Hardcover
  • Copyright: 2003-06-26
  • Publisher: Oxford University Press

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Summary

Vascular dementia, caused by multiple small strokes, is the second commonest cause of dementia behind Alzheimer's disease. In recent years there has been a radical reappraisal of the concept of vascular dementia and a move away from an Alzheimer-based diagnostic paradigm towards one moreappropriately tailored for vascular disease. Vascular Cognitive Impairment presents a new definition for this class of cerebrovascular process with an emphasis on early detection, prompt treatment and the prevention of disease progression. Vascular Cognitive Impairment: Preventable Dementia presents an overview of the current state of our knowledge in this field. It reviews the historical background, prevalence, risk factors and economic consequences of the condition. In addition, the book summarises our knowledge of thepathological process, describing insight derived from genetic and imaging studies, before examining opportunities for early diagnosis, prevention and the options for management, both now, and as a result of ongoing clinical trials. With contributions from an expert team of international contributors, this book provides a comprehensive summary of the state-of-the-art in this field, providing a framework for a new understanding of a complex, disabling but Preventable condition.

Table of Contents

Preface ix
List of Contributors xi
1 Current criteria for vascular dementia - a critical appraisal 1(11)
J.V. Bowler & V. Hachinski
2 Historical evolution of the concept of vascular dementia 12(9)
G.C. Román
3 Prevalence and incidence patterns of vascular dementia 21(12)
W.A. Rocca & D.S. Knopman
4 Evidence-based prognosis of vascular dementia: survival and rate of cognitive decline 33(18)
H.C. Chuff, W. Mack, A. Varpetian, & D. Mungas
5 The cost of vascular cognitive impairment 51(6)
K. Rockwood, M. Brown, & J.D. Fisk
6 Histopathology 57(19)
D.G. Munoz
7 Experimental models of vascular dementia: a focus on white matter disease and incomplete infarction 76(17)
C. Sarti & L. Pantoni
8 Genetics of vascular dementia 93(17)
H.S. Markus
9 Behavioral and psychological symptoms in vascular cognitive impairment 110(16)
K. Rockwood & C. Shea
10 Cognitive patterns 126(13)
D.W. Desmond
11 Measurement of cognition 139(14)
S.H. Ferris
12 Neuropsychological differentiation of Alzheimer's disease and vascular dementia 153(23)
P.S. Sachdev & J.C.L. Looi
13 Anatomical imaging 176(17)
T. Erkinjuntti & T. Pohjasvaara
14 Cerebral blood flow and metabolism in vascular dementia 193(15)
N.S.Ward & M.M. Brown
15 Neurochemical markers 208(9)
M. Sjögren, K. Blennow, & A. Wallin
16 Subtypes of vascular dementia and their pathogenesis: a critical overview 217(13)
L. Pantoni
17 White matter changes in vascular dementia 230(9)
P. Scheltens
18 Post-stroke dementia 239(12)
H. Hénon, F. Pasquier, & D. Leys
19 Vasculitis, collagen vascular disease, and vascular dementia 251(9)
N. Futrell
20 Vascular disorders and Alzheimer's disease 260(17)
I. Skoog & D. Gustafson
21 Treatment of vascular dementias 277(16)
D. Inzitari, M. Lamassa, & L. Pantoni
22 Clinical trials in vascular dementia 293(15)
J. Marler
23 Prevention 308(13)
P.B. Gorelick
24 Vascular cognitive impairment - a new concept 321(18)
J.V. Bowler & V. Hachinski
Index 339

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