Preface and Epilogue

Message from the President of the American Peptide Society

Murray Goodman, Teacher, Mentor, Friend

xiii

In Memoriam: Arno Spatola

People Behind Symposium

xvii

Symposium Sponsors and Exhibitors

xix

American Peptide Society

xxi

American Peptide Symposia

xxii

The Merrifield Award: William F. DeGrado

xxiii

The Makineni Lecture Award: James P. Tam

xxv

Peptide Society Travel Grants

xxvi

Bert Schram Young Investigators' Mini Symposium

xxviii

Young Investigators' Poster Competition

xxix

Abbreviations

xxxi

Contents

xli

Merrifield Award Lecture

De Novo Design of Peptides, Proteins, and Protein Mimetics

(14)

William F. DeGrado

Amino Acid and Peptide Sunthetic Chemistry

An Effective Microwave-Assisted Synthesis of 2,5-Diketopiperazines Libraries

(2)

Maria C. Alcaro, Poetro Bampiglia, Paolo Grieco, Ettore Novellino, Mario Chelli and Anna M. Papini

4-Fluoro-Phenlglcine and 3-Fluoro-Alanine: Labels for 19F-Solid State NMR Structure Analysis of Membrance-Active Peptides

(2)

Parvesh Wadhwani, Sergii Afonin, Marina Berditchevskaja, Ralf W. Glaser and Anne S. Ulrich

Synthesis of 5-FAM-SSSSSSSSSS-OH: Comparison of Fmoc-Ser(Trt)-OH and Fmoc-Ser(tBu)-OH

(2)

Xio-He Tong, Kabun Ichihara, Qing Tian and Anita Hong

Synthesis and Photophysical Properties of Acridonylalanine, a New Fluorescent Amino Acid

(2)

Aneta Szymanska, Katarzyna Wegner, Zbigniew Grzonka and Leszek Lankiewicz

Syntheis of PEG-Inhibitor Conjugates for Affinity Separation of Serine Proteases

(2)

Shin Ono and Makiko Umezaki

N-Methylation at the C-Terminus in Solid Phase Peptide Synthesi

(2)

Yun Wu, Yuan Gao, Wei-Jun Zhang, and Garland R. Marshall

Sterospecific Synthesi of α-Alkyl α,α-Diamino-α-Carboxylates as Core Structural Units of Novel HIV-1 Protease Inhibitors

(2)

Tanaji T, Talele and Mark L. McLaughlin

Amino Acid and Peptide Labeling

(2)

Susana M.B. Fraga, M. Sameiro T. Gonçalves and Hernâni L.S. Maia

The 1-1-Dioxobenzo[b]thiophene-2-ylmetholoxycarbonyl (Bsmoc) Amino-Protecting Group

(2)

Nayan Amin, John Giantsidis, Ted Appleby, Sukhamaya Bain and Ed Price

Facile Synthesis of a Constrained Aza-Dipeptide (ADP)

(2)

Umut Oguz and Mark L. McLaughlin

Synthesis of Azapeptides using N-Boc-Aza¹-dipeptide Building Blocks

(2)

Rosa E. Melendez and William D. Lubell

Efficient Synthesis of Fused Tetracyclic Benzimidazole Systems

(2)

Cornelia E Hoesl, Richard A Houghten and Adel Nefzi

Light-Induced Two-State Structural Transition of a Cyclic PDI-Related Azobenzene-Peptide

(2)

Markus Schütt, Alexander G. Milbradt, Luis Moroder and Christian Renner

Novel Gly Building Units for Backbone Cyclization: Synthesis and Incorporation into Model Peptides

(2)

Sharon Gazal, Gag Gellerman and Chaim Gilon

Application of Aspartic Acid in the Synthesis of Bicyclic Dipeptide Mimetics

(2)

John M. Ndungu, Xuyuan Gu, Dustin E. Gross, Jinja Ying and Victor J. Hruby

Unique Biocatalytic Approach for the Synthesis of Chirally Pure Unnatural a- and b-amino Acids Using Novel Transaminases

(2)

Mohit Bhatia, Eric Law, Craig Lewis, George Matcham, Richard Nelson, Hemlata Rana, Bhavani Stout and Alice Wang

Assessment of 6Cl-HOBt-Based Coupling Reagents in Solid-Phase Cyclopeptide Synthesis

(2)

Giuseppina Sabatino, Maria Claudia Alcaro, Maria de la Cruz Pozo-Carrero, Mario Chelli, Paolo Rovero and Anna Maria Papini

Synthesis and Conformational Study of Peptides Based on Crowned Ca-Methyl L-DOPA

(2)

K. Wright, F. Melandri, M. Wakselman, J.-P. Mazaleyrat, F. Formaggio, S. Oancea, M Crisma and C. Toniolo

Solid-phase Synthesis of des-N-tetramethyl Triostin A (TANDEM)

(2)

John P. Malkinson and Mark Searcey

Total Solid-Phase Synthesis of Differentiation Factor from HL-60 Cells and Related Peptide Fragments

(2)

Lioudmila K. Baidakova, Igor L. Rodionov, Irina A. Kostanyan, Valery M. Lipkin and Vadim T. Ivanov

DioRaSSPâ: Diosynth Rapid Solution Synthesis of Peptides

(2)

Ivo F. Eggen, Frits Bakelaar, Annet Petersen and Paul B.W. Ten Kortenaar

CLEAR-OX™: A New Polymer-Supported Reagent for the Preparation of Disulfide-Bridged Peptides

(2)

Krzysztof Darlak, Andrzej Czerwinski, Miroslawa Darlak, DeAnna W. Long, Francisco Valenzuela, Arno F. Spatola and George Barany

Predicting Lead Compounds Using Libraries of Flexible Molecules

(2)

Adrian Kalászi and Ödön Farkas

Parallel Solid-Phase Synthesis of Difluorinated Dipeptide Analogs

(2)

Agnès Vidal, Richard A. Houghten and Adel Nefzi

Synthetic Peptides as Certified Analytical Standards

(2)

Henriette A. Remmer, Nicholas P. Ambulos, Lynda F. Bonewald, John J. Dougherty, Edward Elsenstein. Elisabeth Fowler, Jinny Johnson, Ashok Khatri, Mark O. Lively, Nadine RitterO and Susan T. Weintraub

A Novel Approach for the Hydrophobic Peptides Synthesis and Purification through O–N Intramolecular Acyl Migration Reaction

(2)

Youhei Sohma, Masato Sasaki, Zyta Ziora, Naoko Takahashi, Tooru Kimura, Yoshio Hayashi and Yoshiaki Kiso

An Efficient Asymmetric Synthesis of Fmoc-L-Cyclopentylglycine Using a Chiral Auxiliary

(2)

Satendra Singh and Michael W. Pennington

Thiazolidine as Protection for Nα-(1-Pheny1-2-Mercaptoethyl) Glycine in Extended Chemical Ligation of Three or More Fragments

(2)

Matteo Villain, Hubert Gaertner and Paolo Botti

Solid-Phase Synthesis of C-Terminal Thio-Linked Glycopeptides

(2)

John P. Malkinson and Robert A. Falconer

Isolation and Characterization of Autoantibodies in Multiple Sclerosis Patients' Sera: Towards a Novel Apheresis Treatment

(2)

Elisa Peroni, Francesco Lolli, Benedetta Mazzanti, Marta Pazzagli, Bruno Bonetti, Johan Hoebeke, Mario Chelli, Paolo Rovero and Anna M. Papini

Small Focused Library of CSF114-type Glycopeptides for the Characterization of Autoantibody Recognition in Multiple Sclerosis

(2)

Francesca Nuti, Ilaria Paolini, Barbara Mulinacci, Maria de la Cruz Pozo-Carrero, Benedetta Mazzanti, Marta Pazzagli, Francesco Lolli, Mario Chelli, Franca Maria Cordero, Alberto Brandi and Anna Maria Papini

O-Glycopeptide Synthesis Made Easy

(2)

Beechanahalli P. Gangadhar, Seetharama D. Jois, Sulaiman Sheriff, William T. Chance and Ambikaipakan Balasubramaniam

Synthesis of Guanidine Compounds Using Resin-Bound Guanidinylating Reagents

(2)

Markus M. Mueller, Hans J. Musiol and Luis Moroder

Facile Synthesis of Protected Hydrazino Amino Acids

(2)

Umut Oguz and Mark L. McLaughlin

Dialkyl Imidazolinones from α, α-Dialkyl Glycines

(2)

S.P.G. Costa, H.L.S. Maia and S.M.MA. Pereira-Lima

A Methionine-Based Linker Strategy for Solid-Phase Synthesis of Lysine-Containing Cyclic Peptides

(2)

Joseph C. Kappel and George Barany

Synthesis of Isotopomers of the MHC II Antagonist AZD2315

(2)

H. Booth, J.R. Harding and D.P. Woodhouse

A Versatile Method for Fast and Selective Introduction of Multiple Probes into Peptides Using Solid Phase Synthesis — Application to Biophysical Models

(2)

Inbar Rofman, Elisha Haas, Varda Ittah and Gerardo Byk

An Efficient Peptide Synthesis in Solution Using Nsc-Amino Acids

(2)

Hyun Jin Lee, Weonu Chweh, Young-Deug Kim, Hyuk-Kwang Jung and Hack-Joo Kim

A Novel Post-Translational Modification: A Conopeptide From Corms gladiator Provides the First Example of γ-Hydroxyvaline (Hyv) Within a Polypeptide Chain

(3)

David Mora, Fred C. Pflueger, Katarzyna Pisarewicz, Gregg B. Fields and Frank Mari

Induced Axial Chirality in the Conformationally Labile, Atropoisomeric Ca,a- Disubstituted Glycine Bip in Peptides

(2)

J-P. Mazaleyrat, K. Wright, N. Toulemonde, A. Gaucher, M Wakselman, Q.B. Broxterman, F. Formaggio, S. Oancea, M. Crisma and C. Toniolo

Preparation and Use of Magnetic Solid Phase Synthesis Supports

100

(2)

Jan Marik, Derick H. Lau and Kit S. Lam

Rapid Microwave-Assisted Solid Phase Peptide Synthesis

102

(2)

Mate Erdélyi, and Adolf Gogoll

Regioselective MCR4 Reaction: One Pot Synthesis of Spiro Heterobicyclic Aliphatic Rings Generated from Natural Amino Acids

104

(2)

Gerardo Byk and Eihab Kahha

Effective Peptide Synthesis Applying Thioesters in the Presence of Metal Ions

106

(2)

Raffaele Ingenito, Dijana Dreznjak, Stefan Guffler and Holger Wenschuh

A Highly Acid-Labile Thiophene Backbone Amide Linker: T-BAL

108

(3)

Ulrik Boas, Mikkel Jessing, Jørn B. Christensen and Knud J. Jensen

A New Method for the Preparation of Peptide C-Terminal a-Thioesters Compatible with Fmoc-Solid-Phase Peptide Synthesis

111

(2)

Julio A. Camarero, Benjamin J. Hackel, James J. de Yoreo and Alexander R. Mitchell

Peptide αThiol Ester Formation Using Standard Fmoc-Chemistry

113

(2)

Regula von Eggelkraut-Gottanka, Annerose Klose, Michael Bienert, Annette G. Beck-Sickinger and Michael Beyermann

Fluorophilic Tagging Reagents for Solid Phase Peptide Synthesis

115

(2)

Dmitri V. Filippov, Dirk J. van Zoelen, Peter C. de Visser, Marcel van Helden, Steven P. Oldfield, Daan Noort, Gijs A. van der Marel, Hermen S. Overkleeft, Jan W. Driffhout and Jacques H. van Boom

Novel Targeting Strategy Based on Multimeric Ligands for Drug Delivery and Molecular Imaging: Homo-oligomers of α-MSH

117

(2)

Josef Vagner, Heather L. Handl, Robert J. Gillies and Victor J. Hruby

P-BOP, a New Polymer-Supported Peptide Coupling Reagent

119

(2)

Sorin V. Filip, Valérie Lejeune, Jean-Pierre Vors, Jean Martinez and Florine Cavelier

New Approach for Peptide Ligation

121

(2)

Nan-Hui Ho, Ralph Weissleder and Ching-Husan Tung

Comparison of Effect of Anionic Ion-Pairing Reagents on Capillary Electrophoresis and Reversed-Phase Chromatography of Cationic Random Coil Peptides

123

(2)

T.V. Popa, Colin T. Mant and Robert S. Hodges

Synthesis of Peptide Thioesters by Masking as Trithioortho Esters in a Fmoc Backbone Amide Linker (BAL) Strategy

125

(2)

Jesper Brask, Fernando Albericio and Knzid J. Jensen

Multiple Condensations of Peptide Thioesters Prepared by the "Safety-Catch" Resin Approach: Synthesis of p53 (303-393)

127

(2)

Kenta Teruya, Sharlyn Mazur and Ettore Appella

Base-Assisted Desulfurization: Synthetic Applications and Mechanistic Studies

129

(2)

Amit K. Galande and Arno F. Spatola

Stereospecific Synthesis of a Carbene-Generating Diazirine Phenylalanine: Non-Selective Photoaffinity Labeling of Angiotensin II Receptors AT1 and AT2

131

(2)

D. Fillon, M. Deraët and E. Escher

ESR-Solvation Study of Different Amine Loaded and Cross-Linked Resins: Implication for Peptide Synthesis and Liquid Chromatography

133

(2)

Elias H. Silva, Erick F. Poletti, Marcia A.F.S. Neves, Fernanda M.B. Coutinho, Shirley Schreier and Clovis R. Nakaie

Asymmetric Syntheses of Enantiomerically Pure α,α-Dialkylated Glycines as Core Structural Units for Novel HIV-1 Protease Inhibitors

135

(2)

Tanaji T. Talele and Mark L. McLaughlin

Preferred Conformation of CαMethyl, CαCyclohexylglycine

137

(2)

Claudio Toniolo, Marco Crisma, Fernando Formaggio, Quirinus B. Broxterman and Bernard Kaptein

Side Reactions During Peptide Cyclization

139

(2)

Haim Tsubery, Tali Scherf and Mati Fridkin

Specificity of PDZ Interaction Using NMR Spectroscopy and Spot Synthesis

141

(2)

Prisca Boisguérin, Rainer Leben, Rudolf Volkmer-Engert, Jens Schneider-Mergener and Hartmut Oschkinat

NMP is Unsuitable as a Solvent for the Rapid Solid Phase Synthesis of CGRP8-37 Using in situ Neutralization

143

(2)

Christopher K. Taylor, Peter W. Abel and D. David Smith,

Isocratic Reversed-Phase Chromatography Separation and Purification of Peptides

145

(2)

A.R. Mehok, C.T. Mant, B. Tripet and R.S. Hodges

New Technology Automates Sorting of Large, Bead-Based Combichem Libraries

147

(2)

K Ver Donck, L. Bols, R. Bongaarts, P. Van Osta, A.J. Brouwer, R.M. Liskamp, D. Perrault, K. Kalutkiewicz, J. Geysen and R. Pulak

Monitoring Self-Association of Small Amphipathic Molecules by Temperature Profiling in Reversed-Phase Chromatography

149

(2)

Darin L. Lee, Colin T. Mont and Robert S. Hodges

Effect of Secondary Structure on Selectivity of Reversed-Phase Chromatography for Peptide Separations at Varying Temperatures

151

(2)

Yusin Chen and Robert S. Hodges

Controlling "Easy" and "Difficult" Fmoc-Deprotections

153

(2)

Phillip W. Banda and Mary Frances Leopold

The Effect of Trp on UV- and Vibrational Circular Dichroism of Helical Peptides

155

(2)

Attila Borics, Chibawanye Ene, Laszlo Otvos Jr, Richard F. Murphy and Sándor Lovas

Improved Automated Waste Handling for the Applied Biosystems 433 Peptide Synthesizer

157

(2)

David H. Singleton, Robert T. Suleske and J. Carter Courtney

X-Cys Ligation

159

(2)

Yi-An Lu and James P. Tam

Orthogonally Protected Sugar Diamino Acids as Building Blocks for Oligosaccharide Mimetics

161

(2)

Frank Sicherl and Valentin Wittmann

Comparison Between NMR And CD Data Of Synthetic Peptides

163

(2)

Fanny Guzmán, Julio C. Calvo, Claudia Reyes, Angela G. Torres, Luz M. Salazar, José M. Lozano and Manuel E. Patarroyo

Molecular Design of Functional Peptides by Utilizing Unnatural Amino Acids that can Coordinate with Metal Ions

165

(2)

Hitoshi Ishida, Masato Kyakuno, Takahiro Nakazato, Mina Fujii and Shigero Oishi

Total Synthesis of Uroguanyline

167

(2)

Yoshitaka Nemoto, Jing Xti, Shawn Lee and Baosheng Liu

Synthesis of Prokineticin 2 Employing a Convergent Solid-Phase Strategy Performed in a Chloroform-Phenol Mixed Solvent

169

(4)

Masanori Ishimaru, Yuji Nishiuchi, Hideki Nishio and Terutoshi Kimura

Peptidomimetic and Pseudopeptide Synthetic Chemistry

3-Aminopiperidones as Dipeptide Constrained Surrogates in Biologically Relevant Compounds

173

(3)

Mònica Garcia, Xavier del Rio, Rachid El Hafi, Patricia López, Eulàlia Pinyol, Jordi Piró, Pilar Forns, Mario Rubiralta, Ernest Giralt, and Anna Diez,

Synthesis of Aminopyrrole Carboxylate Analogs for Peptide Mimicry

176

(3)

Guillaume Jeannotte, Karl A. Hanford, Félix-Antoine Marcotte, Frederik Rombouts, Valeria Zanzarova and William D. Lubell

Advances in a Structure Activity Study of the Aureobasidin Peptide Antibiotics: Synthesis of L-N-Boc-N-Methyl-β-Hydroxyvaline

179

(2)

James E. Dettwiler, Laurent Bélec and William D. Lubell

Backbone Cyclic Peptidomimetic Superantigen Antagonists: Synthesis and Biological Activity

181

(2)

Evgenia Glukhov, Gila Arad, Revital Levy, Karina Hazan, Sharon Gazal, Raymond Kaempfer and Chaim Gilon

Transition Metal Complexes of Linear, Dimeric and Cyclic Pseudopeptides

183

(3)

Siegmund Reissmann, Sebastian Kuenzel, Georg Greiner, Inge Agricola, Sylvia Mueller, David Pretzel, Matthias Schmidt, Raiker Witter and Ullrich Sternberg

Cyclic Peptides from Plants of Genus Linum

186

(2)

B. Picur, P. Ruchala, Lisowski, M. Cebrat, A. Pasternak, R. Zbozieri Pacamaj, P. Stejanowicz, T. Goszczynski and L. Tarnawski

Peptide Mimic Synthesis with Cyclic Sulfamidates

188

(2)

Fabrice Galaud, Priscille Laborde and William D. Lubell

Studies of Photoswitchable β-Hairpin Mimetics

190

(2)

Máté Erdélyi, Anders Karlén and Adolf Gogoll

Lactam Bridge Formation at High Temperature

192

(2)

Alessandra Machado, Giuliano C. Xavier, Giselli H. Lima, Antonio Miranda and Terêsa M. Miranda

Microwave-Assisted Solid-Phase Synthesis of &gamma[CH2NH] Amide Bond Surrogate

194

(2)

Luigi Longobardo, Pietro Compiglia, Isabel Gomez-Monterrey, Ettore Novellino and Paolo Grieco

Metal-Pentaazacrown Peptidomimetics: RGD and WRY

196

(2)

Wei-Jun Zhang, Yon Wu, Yuan Gao, Amruta Poreddy, Urszula Slomczynska, Liwei Chang, Michelle E. Weber and Garland R. Marshall

Enhancing Selectivity, Stability, and Bioavailability of Peptidomimetic Estrogen Receptor Modulators

198

(2)

Arno F. Spatola, Amit K. Galande, Florence M. Brunel, Kelly S. Bramlett, Thomas P. Burris, John O. Trent and James L. Wittliff

Stereoselective Synthesis of 4, 8-Disubstituted Azabicyclo[4.3.0]nonane Amino Acid Esters: Dipeptide β-Turn Mimetics for Melanocortin Peptide Receptors

200

(2)

Junyi Zhang, Xiong and Victor. J. Hruby

Novel Building Blocks for Peptidomimetic Chemistry

202

(3)

Murray Goodman, Juan R. Del Valle and Nicole D. Smith

Solid Phase Syntheses of Monovalent and Bivalent Peptidomimetics of the Neurotrophins

205

(5)

Kevin Burgess

The Sulfonamide Moiety in Peptidomimetics and Peptidomimetic-Peptide Hybrids

210

(3)

Rob M.J. Liskamp, Wilna J. Moree, Dries B.A. De Bont, Dennis W.P.M. Löwik, Arwin J. Brouwer, Menno C.F. Monnee, Remco De Jong and Dirk T.S. Rijkers

Peptoid-Peptide Hybrids as Potent Novel Melanocortin Receptor Ligands

213

(2)

John A.W. Kruijtzer, Wouter A.J. Nijenhuis, Willem Hendrik Gispen, Roger A.H. Adan and Rob M.J. Liskamp

New Methodology for Syntheses of Bicyclic β-Turn Dipeptides (BTD) on Solid Phase Supports

215

(2)

Xuyuan Gu, Josef Vagner, Danice Andrus, Magda Stankova and Victor J. Hruby

Search for Biologically Active Peptidomimetics of beta-Turns and beta-strands Designed Scaffolds and Serendipitous Observations

217

(6)

Ralph Hirschmann and Amos B. Smith, III

Liquid-Phase Synthesis and Conformational Analysis of Pseudoproline-Containing Turn Mimics

223

(2)

C. Tomasini, G. Luppi, D. Lanci, M Garavelli, A. Garelli and V. Trigari

Pseudo-Proline as Reversible Solubilizing Entity in Cyclosporin C

225

(2)

Olivier Turpin, Angela Wittelsberger, Manfred Mutter and Luc Patiny

Synthesis of Modified Prolines for Peptidomimetic Use

227

(2)

Eric Chang, Debra A. Roberts, Yannick Fillon and Jean Chmielewski

Synthetic a-Amino Acids as Building Blocks for Novel RNA Ligands

229

(4)

Andreas Krebs, Oliver Boden, Verena Ludwig and Michael W. Göbel

Protein Mimicry, Engineering, Synthetic Chemistry and Structure-Function

Locally Stable Native-Like Fragments in the Denatured State of PapD Chaperone

233

(2)

James G. Bann, Jeff L.-K. Kao, Yun Wu and Gregory V. Nikiforovich

Chemical Synthesis of Proteins Through Native and Extended Chemical Ligation

235

(5)

Paolo Botti, Matteo Villain, Sonia Manganiello and Hubert Gaertner

Combination of the Convergent and Native Chemical Ligation Methods in the Total Synthesis of Proteins

240

(2)

Dimitrios Gatos, Spyros Goulas and K. Barbs

Chemical Synthesis and Folding/Stability Studies of the Hydrophobic Protein, Crambin

242

(2)

Duhee Bang, Neeraj Chopra and Stephen B.H. Kent

De Novo Four-Helix Bundle Proteins

244

(2)

Heidi K. Huttunen and John C. Sherman

Cavitand Based Four-Helix Bundles

246

(2)

Emily S. Seo and John S. Sherman

Using NMR and Segmental Isotopic Labeling to Elucidate the Role of the N-Terminal Region of s70-like Factors in Regulating Binding of Bacterial RNA Polymerase to DNA Promoter

248

(2)

Julio A Camarero, James J de Yoreo and David Fushman

G protein a-Subunit: Conformation and Dynamics of the C-Terminal Domain

250

(2)

Fabio Casallanovo, Clovis R Nakaie, Antonio CM Paiva and Shirley Schreier

A Biophysical Approach to the Structure of the Rhodopsin: Transducin Interface

252

(2)

Lori L. Anderson, Thomas J. Baranski, Wayne L. Hubbell, Ned Van Eps, Steven O. Smith and Garland R. Marshall

Chemically Modified hIL-8 for Biological Studies

254

(2)

Ralf David, Zuzana Machova and Annette G. Beck-Sickinger

Environmentally Sensitive Hydrogelation Via Designed Peptides

256

(2)

Karthikan Rajagopal, Juliana Kretsinger, Darrin Pochan and Joel P. Schneider

Peptide Microarrays Using Structure-Based Peptide Libraries for Protein Chips

258

(2)

Kenji Usui, Mizuki Takahashi, Tetsunori Ojima, Masato Suzuki, Kiyoshi Nokihara, Eiichi Tamiya and Hisakazu Mihara

A Rationally Designed CD4 Mimic Useful in HIV Inhibition and Vaccine Design

260

(3)

François Stricher, Loïc Martin, Philippe Barthe, Alain Mechulam, Claude Vidaud, Laurent Bellanger, Bernard Maillère, André Ménez, Francisco Veas, Christian Roumestand and Claudio Vita

Engineering New Metal Binding Specificity in Calmodulin Peptides

263

(2)

Loic Le Clainche, Véronique Monjardet and Claudio Vita

Design and Synthesis of Electron Transfer Proteins with Flavin, Heme, and Quinone

265

(2)

Wenwu Li, Thomas Carell and Wolfgang Haehnel

Photo-Control of the Activity of Proteins Via Caging of Their C-Terminus

267

(2)

Jean-Philippe Pellois, Michael E. Hahn and Tom W. Muir

The Chemical Biology of Protein Splicing

269

(7)

Elyse S. Blum, Henning D. Mootz, Izabela Giriat, Alessandra Romanelli, Alexander Shekhtman and Tom W. Muir

The Semisynthesis of the Potassium Channel KcsA

276

(2)

M. Sekedat, F. Valiyaveetil, R. MacKinnon and T.W. Muir

Protein Assembly Using the Staudinger Ligation

278

(2)

Bradley L. Nilsson, Matthew B. Soellner and, Ronald T. Raines

Rao Makineni Lecture

Protein Mimetics as HIV Therapeutics and Vaccines Prepared by Tandem Ligation

280

(10)

James P Tam

Three-Helix Bundles of HIV Mimics Fusion State and Blocks M- and T-Tropic HIV-1 Entry into Host Cells

290

(2)

Jin-Long Yang, Qitao Yu, Hua Li and James P. Tam

Manipulating the Hydrophobic Core of a Coiled Coil Peptide Self Replicator

292

(2)

Xiangqun Li and Jean Chmielewski

Synthetic Expansion of the Central Dogma: Chemical Aminoacylation, 4-Base Codons and Nonnatural Mutagenesis

294

(7)

Masahiko Sisido

Cytoplasmic Domain Of E. con ProP Forms an Antiparallel Coiled-Coil as Determined by NMR Spectroscopy

301

(2)

David L. Zoelewey, Brian Tripet, Tatiana G. Kutateladze, Michael J. Overduin, Janet M. Wood and Robert S. Hodges

De novo Design, Synthesis and Properties of Model Quinoproteins

303

(4)

Wenwu Li, Michaela Ritter, Petra Hellwig, Jürgen Heinze and Wolfgang Haehnel

Protease and Enzyme Substrate/Inhibitor Structure-Function

Different Approaches to Inhibit the Chymotrypsin-Like Activity of the 20's Proteasome

307

(3)

Pascal Furet, Patricia Imbach, Carlos Garcia-Echeverria, Marc Lang, Johannes Roesel, Maria Noorani, Johann Zimmermann, Peter Fuerst and Vito Guagnano

Synthesis and Evaluation of Phosphonopeptide Cathepsin C Inhibitors

310

(3)

Pawel Kajarski, Marcin Drag, Lukasz Berlicki and Malgorzata Pawelczak

Cyclic Peptide Inhibitors of α-Amylase Based on Tendamistat

313

(2)

Leena Khullar, Steve M. Fernandes, James M. Waner, Elizabeth J. Blaney, Dennis A. Brown and Deborah L. Heyl

Betaine: Homocysteine Methyltransferase from Rat Liver: Purification and Inhibition by a Boronic Acid Substrate Analog

315

(2)

Payman Amiri, Mark Cava, Kyung-Hee Lee, Robert N. Lindquist and Tom Ottoboni

Activity and Refolding of Partially Folded Analogues of BPTI

317

(2)

George Barany, Irina V. Getun, Judit Tulla-Puche and Clare Woodward

Solid-Phase Synthesis of Amidoketones: Towards Caspase Inhibitors

319

(2)

Jesús Vázquez, and Fernando Albericio,

Synthesis and Biological Evaluation of Dipeptde Boronic Acids as Potent DPP IV Inhibitors

321

(2)

J.H. Lai, W. Wu, H. Maw, Y. Zhou and W.W. Bachovchin

Cyclic Tetrapeptides Containing a Zinc Ligand as Novel Histone Deacetylase Inhibitors

323

(2)

Binoy Jose, Tamaki Kato, Yuko Sumida, Minoru Yoshida, and Norikazu Nishino,

In Vivo Imaging of Thrombosis-Associated Enzyme Using Fluorescence Peptide Probes

325

(2)

Ching-Hsuan Tung, Nan-Hui Ho, Qing Zeng and Ralph Weissleder

A Fluorescence Resonance Energy Transfer Substrate (FRETS) Library for Determining Protease Specificity

327

(2)

Katsumi Takada, Masahiko Tsunemi, Yuji Nishiuchi and Terutoshi Kimura

Synthesis and Biological Activity of Dimeric HIV-1 Integrase Inhibitory Peptides

329

(2)

Krzysztof Krajewski†, Ya-Qiu Long, Christophe Marchand, Yves Pommier and Peter P. Roller

Peptide-lead Nonpeptidic Protease Inhibitor Targeting Multi-drug Resistant Strains of HIV

331

(2)

Nobutaka Fujii, Hirokazu Tamamura, Tomonori Yamasaki, Akira Otaka, Yasuhiro Koh, Manabu Aoki, Kenji Maeda, Kazuhisa Yoshimura and Hiroaki Mitsuya

Molecular Dynamics of the Caspase-3 Cleaved N-Half of Gelsolin

333

(2)

Inta Liepina, Paul Janmey, Cezary Czaplewski and Adam Liwo

Synthesis of Glutathione Peptidomimetics

335

(2)

Tunde Matola and Istvan Jablonkai

Aib Modified Dimerization Inhibitor of HIV-1 Integrase

337

(2)

Lei Zhao and Jean Chmielewski

HIV-1 Protease Dimerization Inhibitors: Reversing the Southern Peptide

339

(2)

You Seok Hwang and Jean Chmielewski

CD Analysis of Structure and Lipid Interacting Property of Inhibitors of Proprotein Convertases

341

(2)

A. Basak, K. Beking, M Chrétien and S. Basak

Cellular Delivery and Design of Cell Transportable Inhibitors of Proprotein Convertases

343

(3)

A. Basak, F. Dong and S. Basak

Immobilized Bivalent Inhibitors as Tools for the Affinity-based Isolation of Human Mast Cell Tryptases

346

(2)

Norbert Schaschke, Dusica Gabrijelcic-Geiger, Andreas Dominik and Christian P. Sommerhoff

Cyclic Biphenyl Ether Tripeptides as Proteasome Inhibitors

348

(2)

Markus Kaiser, Alexander G. Milbradt, Christian Renner, Irmgard Assfalg-Machleidt, Michael Groll, Robert Huber and Luis Moroder

Triple-Helical Peptide Ligand Dissection of Unique Melanoma Cell Signaling Pathways

350

(3)

Janelle L. Lauer-Fields, Mohammad Al-Ghoul, Diane Baronas-Lowell, Jeffrey A. Borgia and Gregg B. Fields

Synthesis of (Ac-XFRSLK)2 -Rhodamine 110

353

(2)

Xiao-He Tong and Anita Hong

Synthesis and Activity of a Novel Peroxidase Mimetic Peptide

355

(2)

Yali Liu, Lill Guo, Hui Yang, Jingming Zhang, Roger W. Roeske and Wei Li

Novel Potent Peptides That Regulate Phenoloxidase Activity

357

(2)

Takashi Sato, Chihiro Awada and Yoshimi Ogata

Methanethiosulfonyl Derivatives of Linear and Cyclic Peptides as Novel Reagents to Study Topology of Active Center Gorge of Acetylcholinesterase

359

(2)

Peteris Romanovskis, Terrone L. Rosenberry, Bernadette Cusack and Arno F. Spatola

Peptide Anticoagulants in a Rat Model of Disseminated Intravascular Coagulation

361

(2)

Sándor Bajusz, Éva Barabás, Irén Fauszt, Gabriella Szabó and Attila Juhász

Solution Structure of a Cyclic Peptide, Subtilosin A, With Unusual Post-translational Modifications

363

(2)

Tara Sprules, Karen E. Kawulka, Ryan T. McKay, Pascal Mercier, Christopher M. Diaper, Peter Zuber and John C. Vederas

Synthesis and Biological Evaluation of Dimeric uPAR Antagonists and Aomatostatin Analogs

365

(2)

A. Modlinger, M Sukopp, M Buergle, K. Wosikowski and H. Kessler

Peptide-Based Near Infrared Opitical Probes Specific For Matrix Metalloproteinases Activity Detection

367

(4)

Wellington Pham, Ralph Weissleder and Ching-Husan Tung

Peptide Structure-Conformation-Function And Molecular Modeling

2D NMR Studies of Dynorphin A(1-13) in Solution: Potent kappa Opioid Receptor Agonist

371

(2)

V. Renugopalakrishnan, Shaw-Guang Huang and M. Prabhakaran

Effects of Arsenic(III) Binding on α-Helicity

373

(2)

Daniel J. Cline, Colin Thorpe and Joel P. Schneider

310-Helix in Aib-Rich Peptides Containing Lactam-Bridged Side-Chains: Spectroscopic Characterization in TFE by CD and NMR

375

(2)

Elisabetta Schievano, Katiuscia Pagano, Stefano Mammi and Evaristo Peggion

Amphipathic α-Helix Apolipoprotein A-I Peptide Models as Atheroprotective Probes: Design, Construction and Phospholipid/Cholesterol Interactions

377

(2)

Charalampos Alexopoulos, John Mitsios, Alexandros Tselepis, Maria Sakarellos-Daitsiotis and Constantinos Sakarellos

Receptor-Bound Characteristics of MiniANP Analyzed by NMR, MM/MD, and the Use of Unusual Amino Acids

379

(2)

K. Sugase, M. Horikawa and M. Ishiguro

α, α-Dialkylated β-Hairpin Peptides: Design, Synthesis, and Conformational Analysis

381

(2)

Catherine L. Thomas, Marcus A. Etienne, Jia Wang, Vladimir Setnicka, Timothy A. Keiderling and Robert P. Hammer

Computational Design and Chemical Synthesis of a β-Sandwich Protein

383

(3)

Kai Fritzemeier and Wolfgang Haehnel

Design and Conformational Analysis of Peptides Containing α,α-Disubstituted Amino Acid

386

(2)

Jia Wang, Yanwen Martha M. Juban and Robert P. Hammer

An Encoding Method for One-bead One-compound Beta-turn Peptide and Peptidomimetic Libraries

388

(2)

Ruiwu Liu, Xiaobing Wang, Jan Marik and Kit S. Lam

Synthetic Bivalent Inhibitors Based on the Bowman Birk Inhibitors: The BiKK Inhibitor

390

(2)

Agnès M Jaulent and Robin J Leatherbarrow

Understanding b-Structure in Peptides and Proteins

392

(8)

Andrea G. Cochran, Nicholas I Skelton and Melissa A. Starovasnik

Molecular Dynamic Investigation of the β-Turn Forming Nature of Tetra- and Hexapeptides

400

(2)

Attila Borics, Richard F. Murphy and Sándor Lovas

Discovery and Applications of the Cyclotides: Circular Proteins from Plants

402

(5)

David J. Craik, Norelle L. Daly, Michelle L. Colgrave and K. Johan Rosengren

Design of Novel Template Peptides to Mimic the Coiled Coil Conformation of the gp21 Envelope Subunit of HTLV-1 for the Induction of Neutralizing Antibodies

407

(2)

Roshni Sundaram, Sharad V. Rawale, Yiping Sun and Pravin T.P. Kaumaya,

Importance of Hydrophobic Clusters on Protein Folding and Stability

409

(3)

Stephen M. Lu, Stanley C. Kwok and Robert S. Hodges

Visual Molecular Recognition of cAMP with Azo-Bridged Cyclic Peptide Libraries

412

(2)

Martina Cižková, Martin Šafarik, Jaroslav Šebestik, Jan Hlavácek and Ivan Stibor

Organic Functionalization of Carbon Nanotubes with Peptides

414

(2)

D. Pantarotto, C. D. Partidos, J. Hoebeke, J -P. Briand, M. Prato and A. Bianco

Structural and Biological Studies of a Penetratin-Linked Gas C-Terminal peptide

416

(2)

Anna M. D'Ursi, S. Albrizio, L. Giusti , M Mazzoni, E. Novellino and P. Rovero

Structural Analysis of Nanomolar Quantities of Marine Neuropeptides Using 2D-NMR Methods

418

(2)

Elena Matei, Fred Pflueger, Aldo Franco, Herminsul Cano, David Mora and Frank Mari,

Solution Structure of α-Conotoxin OmIA, a Neuronal Toxin Specific for the a4b4 Subunit Interface of Neuronal Nicotinic Acetylcholine Receptor

420

(2)

Seung-Wook Chi, Do-Hyoung Kim and Kyou-Hoon Han

Cyclic Proline Peptides as Privileged Reverse-Turn Templates

422

(2)

Ye Che and Garland R Marshall

Synthesis and Ca²+ Interactions of Model Amphipathic Cyclic Peptides in Detergents

424

(2)

Day Gates, Jack Rostas, Victor Bailey and Maria Ngu-Schwemlein

Conformational Preferences and Biological Activity of Short Peptides Containing (E)-Dehydrophenylalanine

426

(2)

Rafal Latajka, Michal Jewginski, Malgorzata Pawelczak, Maciej Makowski and Pawel Kafarski,

Controlled Assembly of Carbon Nanotubes in Aqueous Solution with Designed Peptides

428

(3)

Gregg R. Dieckmann, Alfonso Ortiz-Acevedo, Alan B. Dalton, Joselito Razal, Jian Chen, Edgar Muñoz, Inga H. Musselman, Ray H. Baughman, and Rockford K. Draper

Role of Disulfide Bonds in the Folding of Prouroguanylin and Heat-stable Enterotoxin

431

(2)

Yuji Hidaka, Len Ito and Hiroshi Yamaguchi

Pseudopeptide Foldamers. The Homo-oligomers of 4(S)-Oxazolidineacetic Acid, 2-Oxo (Oxac)

433

(2)

C. Tomasini, G. Luppi, S. Oancea, F. Formaggio and C. Toniolo

Cα Methyl Norvaline Foldamers

435

(2)

Fernando Formaggio, Marco Crisma, Claudio Toniolo, Quirinus B. Broxterman, Bernard Kaptein, Catherine Corbier, Michele Saviano, Pasquale Palladino and Ettore Benedetti

Structure-Activity Studies of cis-γ-Amino-L-Proline Oligomers: Probing the Relationship between Conformational Stability and Cellular Internalization Capacity

437

(2)

Josep Farrera-Sinfreu, Ernest Giralt, Miguel Pons, Susana Castel, Fernando Albericio and Miriam Royo

Helix Formation in Oligomers of y-Amino Acids (γ-Peptides)

439

(2)

Carsten Baldauf, Robert Günther and Hans-Jörg Hofmann

Vinylogous g-Amino Acids as Building Blocks for Foldamers

441

(2)

Carsten Baldauf Robert Günther and Hans-Jörg Hofmann

Role of Intramolecular Hydrogen Bonds on the Electron Transfer Rate in Structurally Defined Peptides

443

(2)

Fernando Formaggio, Alessandro Moretto, Sabrina Antonello, Flavio Maran and Claudio Toniolo

A Structural Study of a Series of Conformationally Restricted Hexapeptides

445

(2)

Basilio Pispisa, Lorenzo Stella, Mariano Venanzi, Antonio Palleschi, Michel Wakselman, Jean-Paul Mazaleyrat, Ferdinando Fomaggio and Claudio Toniolo

Solution Structure of Daptomycin

447

(3)

Kenneth S. Rotondi and Lila M Gierasch,

One Good Turn Deserves Another: Regular Turns in Peptide and Nucleic Acid Templates

450

(3)

Christian Lehmann

Molecular Modeling of Opioidmimetics Containing the Dmt-Tic-Bid Pharmacophores and Docking with the &delta-Opioid Receptor

453

(2)

Sharon D. Bryant, Severo Salvadori, Remo Guerrini, Gianfranco Balboni, Yunden Jinsmaa and Lawrence H. Lazarus

Molecular Dynamics Simulations of BNP Binding to the NPRA Receptor Dimer

455

(2)

B.C. Wilkes, A. De Léan and P.W. Schiller,

The Symmetries in Changes of Conformational Equilibria Thermodynamic Parameters made by Structure Modifications in Peptides

457

(2)

Boleslaw Picur

Tripeptides as Model Systems to Understand the Random Coil Conformation of Peptides and Proteins: Ionized Tri-aspartatc and Tri-Glutamate in Water

459

(3)

Reinhard Schweitzer-Stenner, Fauna Eker, Coo Xiaolin and Laurence Nafie

Analysis of Peptide β-Sheet Models Using Chemical Shia Deviations

462

(2)

Niels H. Andersen, R. Matthew Fesinmeyer and F. Michael Hudson

Photodimerization in Peptides for High-Density Optical Data Storage

464

(2)

Rolf H Berg and PS Ramanujam

Segmental Isotopic Labeling of RNA Polymerase for NMR Studies

466

(2)

Edmund C. Schwartz, Alexander Shekhtman, Seth A. Darst, David Cowburn and Tom W. Muir

Role of Aromatic Residues in the Structure and Biological Activity of the Small Cytokine, Growth-Blocking Peptide (GBP)

468

(2)

Masahito Tada, Tomoyasu Aizawa, Mineyuki Mizuguchi, Katsutoshi Nitta, Yoichi Hayakawa and Keiichi Kawano

Analysis of Structure and Metal Binding Properties of Secretoneurin and Related Peptides by CD and MALDI-MS

470

(2)

Ajoy Basak, Jane MacAulay and Vance Trudeau

Effect of 4-Fluoroproline in the X-Position on the Stability of the Collagen Triple Helix

472

(2)

Jonathan A Hodges and Ronald T Raines

Synthesis and Calcium Binding of Oligomeric Tropoelastin Analogs

474

(2)

Hiroaki Kodama, Shuhei Ueno, Satoshi Osada, Iori Maeda, Kouji Okamoto and Michio Kondo

Unique Structural Elements Profoundly Influence the Conformation of SOM230

476

(2)

Lukas Oberer, Gianluca Interlandi, Amedeo Caflisch, Günter Bovermann, Claus Ehrhardt and Ian Lewis

Venom Proteomics & Drug Discovery

478

(2)

Reto Stöcklin, Sophie Michalet, Laure Menin, Philippe Bulet, and Philippe Favreau

Fusion of Small Dimerizer Sequence at The Terminal Ends of a Linear Random Coil Peptide Induces Conformational Switch

480

(2)

Tarikere L. Gururaja, Donald G. Payan and D.C. Anderson

Conformational Conversion of Prion Proteins: Role Synthetic PRP 173-195 Fibrillogenic Peptide

482

(2)

Barbara Tizzano, Daniela Marasco, Ettore Benedetti, Antonia De Capua, Pasquale Palladino, Carlo Pedone, Giuseppe Perretta, Filomena Rossi, Raffaele Ragone and Menotti Ruvo

NMR Structure Investigation of α-MSH using TOAC Labeling

484

(2)

Renata de Freitas F. Vieira, Katya Sousa, Clóvis R. Nakaie, Shirley Schreier, Paulo M Bisch, Fábio C.L. Almeida and Ana P. Valente

Antimicrobial and Insecticidal Effects of Crude Extract Momosertatin from Momordica cochinchinensis

486

(2)

Dung Le Nguyen, Annie Heitz, Laurent Chiche, Jean-François Hernandez, Thi Ha Phan and Tran Chau Pham

Effects of NOOPEPT in the Photochemically Induced Stroke Model

488

(2)

Galina A. Romanova, Tatjana A. Gudasheva, Rita U. Ostrovskaya and Fatima M. Shakova

Effect of Chain Length on Coiled-Coil Stability: Decreasing Stability with Increasing Chain Length

490

(5)

Stanley C. Kwok and Robert S. Hodges

Intracellular Signaling, Metabolism and Gene Regulation Structure-Function

Inhibition of HuPrP106-26 Aggregation in Presence of dsDNA by Peptide Libraries

495

(2)

Jaroslav Šebestik, Lenka Borovicková, Jan Hlavácek and Ivan Stibor

Development of Peptides Able to Modulate the Interaction of AKAP121 with Mitochondria

497

(2)

Michele Saviano, Laura Zaccaro, Ettore Benedetti, Carlo Pedone, Annarita del Gatto, Antonio Feliciello, Adele Affaiatati and Enrico V. Avvedimento

Synthesis of Heterodimeric Glycopeptide Hormone Containing Four Disulfide Bonds

499

(2)

H. Hojo, H. Nagasawa and Y. Nakahara

Peptidomimetic Design of Cyclic Grb2-SH2 Domain Antagonists not Relying on pTyr or its Mimics

501

(3)

Peter P. Roller, Peng Li, Manchao Zhang, Xiaodong Zhang, Ya-Qiu Long, Megan L. Peach, Marc Nicklaus, Hongpeng Liu and Dajun Yang

The Structure of a Cyclic Peptide Inhibitor of pp60c-src

504

(2)

K. Kaluarachchi, J.W. Rice, W. Wang and J.S. McMurray

Synthetic Approaches to the Bioactive Marine Cyclodepsipeptide Halipeptin A

506

(2)

Assunta Napolitano, Ines Bruno, Luigi Gomez-Paloma, Raffaele Riccio, Nakia Maulucci, Carmela Della Monica, Irene Izzo and Francesco De Riccardis

Toward the Synthesis of New Designed Analogues of the Marine Cyclodepsipeptide Jaspamide

508

(2)

Stefania Terracciano, Ines Bruno, Giuseppe Bifulco, Luigi Gomez-Paloma and Raffaele Riccio

Direct Translocation of Histone Molecules Across Cell Membrane

510

(2)

Elana Hariton-Gazal, Joseph Rosenbluh, Chaim Gilon and Abraham Loyter

Peptides as A New Family of Compounds with Estrogen-Like Activity

512

(3)

Roni Kasher, Batya Gayer, Tikva Natarajan Venkatesh, Dalia Somjen, Mati Fridkin, Ephraim Katchalski-Katzir and Fortune Kohen

Macrocyclization in the Design of Tetrapeptide Mimetics that Display Potent Inhibition of Grb2 SH2 Domain Binding in Whole Cell Systems

515

(3)

Z.-D. Shi, C.-Q. Wei, X. Wang, K. Lee, H. Liu, M. Zhang, J. Vasselli, L.R. Roberts, K.M. Worthy, M Fivash, R.J. Fisher, D.P. Bottaro, W.M. Linehan, D. Yang and T.R. Burke, Jr.

Potent Grb2-SH2 Domain Antagonists Discovered by Extensive SAR Studies

518

(2)

Peng Li, Megan L. Peach, Manchao Zhang, Hongpeng Liu, Dajun Yang, Marc Nicklaus and Peter P. Roller

Protein P2 from Haemophilus influenzae: The Role of its Surface Exposed Loops on the Mitogen-Activated Protein Kinase Cascade

520

(2)

Stefania Galdiero, Domenica Capasso, Mariateresa Vitiello, Marina D'Isanto, Erminia Di Niola, Simona Monti, Menotti Ruvo, Carlo Pedone, and Massimiliano Galdiero

RDP58, A Rationally Designed Peptide, Inhibits Multiple Forms of Pathogenic Inflammation Through the Inhibition of p38MAPK and JNK

522

(2)

Suhasini Iyer, Ricardo Gonzalez, Jingsong Zhao, Mirella Lazarov, Ajith Welihinda, Roland Buelow, Alexis Te and Timothy Fong

Endeavors Toward a Specific Inhibitor for HDAC6

524

(2)

Tamaki Kato, Binoy Jose, Shinji Okamura, Yuko Sumida, Minoru Yoshida, and Norikazu Nishino,

The Proteome and the Metabolome - A Structural Perspective

526

(8)

Irene Nobeli and Janet M. Thornton

Synthesis and Application of Large Phosphopeptides from the Linker for Activation al- Cells (LAT) Protein

534

(2)

Hiroshi Yamaguchi, Jon C.D. Houtman, Lawrence E. Samelson and Ettore Appella

Binding Interactions of Phospho-Htc Peptide to c-Fgr SH2 Domain

536

(2)

Paolo Ruzza, Alessio Osier, Silvia Del Piero, Arianna Donella-Deana, AnnaMaria Brunati, Giuliano Siligardi, Rohanah Hussain, Andrea Calderan, Andrea Guiotto, Lorenzo A. Pinna and Gianfranco Borin

Fluorescence Detection of Conformationally-Restricted Oxy-Peptide Nucleic Acids/DNA hybrids

538

(2)

Mizuki Kitamatsu, Mamoru Saito, Takashi Nakai and Masahiko Sisido

Preparation of Fluorescent and Radiolabeled Peptide-PNA Conjugates for Imaging bcl-2 Expression

540

(2)

Fabio Gallazzii, Fang Jia, Linda A. Landon, Nalini Shenoy, Geethapriya Sivagurit, Mark Hannink, Susan Z. Lever, and Michael R. Lewis,

Solid Phase Synthesis of Tri-Peptide Derivatives of Kojic Acid Used as Tyrosinase Inhibitor

542

(2)

Hanyoung Kim, Jaehee Choi and Yoon-Sik Lee

Tripeptide Inhibitors of Yersinia Protein-Tyrosine Phosphatase as Potential Leads for Therapeutic Development Against Plague

544

(2)

Kyeong Lee, Sang Uk Kang, Yang Gao, Zhu-Jun Yao, Jason Phan, Li Wu, Jiao Liang, David S. Waugh, Zhong-Yin Zhang and Terrence R. Burke, Jr.

Interference with Protein-Protein Interactions in Signal Transduction

546

(2)

Frank J. Dekker, Nico J. de Mol, Marcel J.E. Fischer and Rob M.J. Liskamp

Testing and Characterizing Focused Tyrosine Kinase Inhibitory Libraries

548

(2)

Györgyi Bökönyi, Eszter Schäfer, Edit Várkondi, Edit Z. Szabó, Frigyes Wáczek, Zsolt Székelyhidi, Péter G.Bánhegyi, György Mészáros, Dániel Erös, László Örfi, Ákos Pap, Richárd E. Schwab and György Kéri,

The Development of Peptide-Based Inhibitors of Stat3alpha

550

(3)

Zhiyong Ren, David R. Coleman, Larry A. Cabell and John S. McMurray

Novel Neutrophil-Activating Peptides: Physiological Roles of Direct Activation of GTP- Binding Regulatory Proteins by These Peptides

553

(3)

Hidehito Mukai, Yuko Matsuo, Rie Kamijo and Kaori Wakamatsu

Ribonucleopeptide Receptors

556

(3)

Masaki Hagihara, Tetsuya Hasegawa, Shin-ichi Sato, Susumu Yoshikawa, Katsutoshi Ohkubo and Takashi Morii,

Deformation of One a-Helix Leads to S-S Bond Formation of YhhP

559

(6)

Toshimasa Yamazaki, Etsuko Katoh, Shizue Katoh, Yuki Tsunoda and Takeshi Mizuno

Receptor and Ion Channel Agonist/Antagonist Structure-Function

Structure and Function Studies of a Bicyclic Agouti-Related Protein (AGRP) Melanocortin-4 Receptor Antagonist

565

(2)

Andrzej Wilczynski, Xiang S. Wang, Rayna M Bauzo, R. Thirumoorthy, Zhimin Xiang, Arthur S. Edison, Nigel G. J. Richards and Carrie Haskell-Luevano

NMR Structure-Based Design of a-MSH Peptide Analogues

567

(2)

Jinfa Ying, Katalin E. Kövér, Xuyuan Gu, Guoxia Han, Josef Vagner, Minying Cai, Christopher M Cabello, Chiyi Xiong, Junyi Zhang, Dev B. Trivedi, Malcolm J. Kavarana and Victor J. Hruby

Design and Synthesis of Novel Antihypertensive Drugs

569

(2)

Panagiotis Zoumpoulakis, Ioanna Kyrikou, Nektarios Giatas, Demetrios Gatos, Maria-Eleni P. Androutsou, Papanastasiou, Anastasia Zoga, P.M. Minakakis, G. Kokotos, Demetrios Vlahakos, Eustathios Iliodromitis and John Matsoukas

Novel Angiotensin II Lactam Bridge Cyclic Analogues

571

(2)

Vani X. Oliveira Jr., Alessandra Machado, Marcos A. Fázio, João B. Pesquero, Edson L. Santos, Cláudio M.C. Neto and Antonio Miranda

Shortcuts to Receptor Structures with Peptide Photoprobes: Angiotensin Receptors

573

(5)

Emanuel Escher, Maud Deraët, Jacqueline Pérodin, Marie-Ève Beaulieu, Lenka Rihakova, Martin Clément, Antony A. Boucard, Gaétan Guillemette, Richard Leduc and Pierre Lavigne

Synthesis and Evaluation of Substituted Benzophenone Photolabeling Amino Acids for the Methionine Proximity Assay

578

(2)

Martin Clément, Maud Deraët, Marie-Ève Beaulieu, Lenka Rihakova, Marie-Thérèse Bawolak, Gaétan Guillemette, P. Lavigne, R. Leduc and Emanuel Escher

The Name Game: Use of Words Composed of Letters of the English Alphabet as a Source of Novel Bioactive Peptides

580

(2)

David Wade

Beta-Methyl Substitution of the Cha Residue in Dmt-Tic-Cha-Phe Peptides Provides Highly Potent Delta Antagonists

582

(2)

Dirk Tourwe, Geza Toth, Gunter Carlens, Csaba Tomboly, Antal Péter, and Peter W Schiller

BKM-570 and Its New Acyl-Amino Acid Amide Analogs for Lung and Prostate Cancer

584

(2)

Lajos Gera, Daniel C. Chan, Eunice J. York, V. Simkeviciene, Adomas Vagonis, D. Bironaite, P.A. Bunn, Jr., Laimute Taraseviciene-Stewart and John M. Stewart,

Identification of a Direct Interaction Between Calcitonin Peptide and its Receptor

586

(2)

Vi Pham, John D. Wade, Brooke W. Purdue and Patrick M Sexton

A Cyclic and Branched Peptide as a New Selective Ligand for the CCKA Receptor

588

(2)

Ettore Benedetti, Giancarlo Morelli, Raffaella Della Moglie, Stejania De Luca, Michele Saviano and Luigi Aloj

Interhelical Side Chain-Side Chain Hydrogen Bonds in Membranes: Capture Potential of Aspartic Acid vs. Glutamic Acid

590

(7)

Charles M. Deber, Mei Y. Choi, and Lia Cardarelli

A Simplified Model of the Interaction Between SDF-1 Chemokine and the CXCR4 Receptor

597

(2)

Pasquale Palladino, Antonia De Capua, Carlo Pedone, Raffaele Ragone, Filomena Rossi, Cristina Limatola, Davide Ragozzino and Ettore Benedetti

Synthetic Unnatural Chemokines: Probes of Receptor-Ligand Interactions and Inhibitors of HIV-1 Entry

599

(2)

Ziwei Huang, Santhosh Kumar, Chang-Zhi Dong, Dongxiang Liu, Shaomin Tian, Won-Tak Choi, Mull Wang, Vitaly Stepensky, Ying Li, Jing An, Navid Madani, Mark Cayabyab and Joseph G Sodroski

Enhanced Hepatic Clearance of Plasma Cholesterol and Inhibition of Atherosclerosis by an Apolipoprotein E-mimetic Peptide

601

(3)

David W. Garber, Himanshu Gupta, Shaila Handattu, Geeta Datta, Manjula Chaddha, M.N. Palgunachari, C. Roger White and G.M Anantharamaiah

Development of CRF-R2 Selective Peptide Ligands

604

(2)

Doreen Wietfeld, Angelika Ehrlich, Reinhard Seifert, Klaus Fechner, Eberhard Krause, Michael Bienert and Michael Beyermann

Discovery of a Novel CXCR4 Antagonist Using Two Orthogonal Cyclic Peptide Libraries

606

(3)

Shinya Ammo Niida, Kenichi Hiramatsu, Satoshi Ueda, Takanobu Araki, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigoni Terakubo, Hideki Nakashima, Zi-xuan Wang, Stephen C. Peiper and Nobutaka Fujii

Design, Synthesis and Pharmacological Evaluation of Potential CXCR4 Chemokine Antagonist Peptides on Breast Cancer Cells

609

(2)

Xin Wang, Kin Wang, J.-P. Perchellet and Sandra C. Vigil-Cruz

Synthesis of Branched Cyclic Peptide Analogs of Angiotensin II

611

(2)

Yuan Gao, Yam Wu, Wei-Jun Zhang and Garland R. Marshall

QSAR Analysis of Ring-Substituted Tyrosine Replacements at the N-Terminus of a Nonselective Deltorphin Analog

613

(2)

Deborah L. Heyl, Kutralanathan Renganathan, Malika N. Jayamaha, David W. Rodgers and Stephen E. Schullery

New Paradigm For Drug Design: Overlapping Pharmacophores of Opioid And Cholecystokinin Ligands In The Design Of New Compounds For The Treatment Of Neuropathic Pain

615

(2)

Richard S. Agnes, Yeon S. Lee, Shou W. Ma, Peg Davis, Todd Vanderah, Jinfa Ying, Katahn Kövér, Josephine Lai, Frank Porreca and Victor J. Hruby

A New Series of Endothelin Receptor Antagonists

617

(2)

Ke-Liang Liu, Jun-Jun Dong, Bo Geng, Yuan-Jun Liang, Han Han Ping Wu, Mu-Gen Chi and Ze-Hui Gong

An Unexpected Modification of Histidine During the Preparation of Ghrelin

619

(2)

David L. Smiley, Steven Afendis, Melvin G. Johnson, Joseph V. Manetta, Xiliang Wang, Derrick R. Witcher and Lianshan Zhang

Misfolded Therapeutic Peptides Give Rise To Caspase-Mediated Cytotoxicity

621

(2)

Satomi Onoue, Keiichi Ohshima, Kazuhiro Debari, Keitatsu Koh, Takehiko Yajima and Kazuhisa Kashimoto

Long Acting Peptide (LAP™) Analogues of Glucagon-Like Peptide-1

623

(2)

Abdelkrim Habi, Daniel Abran, Krishna G. Peri, Patricia Brubaker and Thierry Abribat

Design and Synthesis of Novel GLP-1 Analogs that have Significantly Improved In Vivo Activities

625

(3)

Jesse Z. Dong, Yeelana Shen, Jundong Zhang, John E. Taylor, Chee-Wai Woon, Barry Morgan, S. Skinner, M. Cawthorne, M. Culler and Jacques-Pierre Moreau

The Role of Residues 5-8 of Lamprey Gonadotropin-Releasing Hormone III in the Inhibition of Cancer Cell Growth

628

(2)

Krisztina Herédi-Szabó, Jeremiah Lubke, Richard F. Murphy and Sándor Lovas

Native Chemical Ligation of Transmembrane Receptor Fragments of Ste2p

630

(2)

Vommina V. Suresh Babu, Jeffrey M. Becker and Fred Naider

Development of Highly Potent and Selective Low Molecular Weight Agonists for the Human Orphan Receptor BRS-3

632

(3)

Horst Kessler, Dirk Weber and Jochen Antel

Synthesis and Cross-Linking of Photoactivateable Biotinylated Ligands of G Protein- Coupled Receptors

635

(2)

Hasmik Sargsyan, Cagdas D. Son, Jeffrey M. Becker and Fred Naider

Cyclic Melanocortin-4 Receptor Ligands: Conformational Analysis Using 1 H-NMR Spectroscopic Methodologies

637

(2)

Jerry Ryan Holder, Arthur S. Edison, Zhimin Xiang, Joseph W. Scott and Carrie Haskell-Luevano

Stereochemical Inversion Studies of Monocyclic hAGRP(103-122) Peptide

639

(2)

Christine G. Joseph, Xiang S. Wang, Joseph W. Scott, Rayna Bauzo, Zhimin Xiang, Nigel G. Richards and Carrie Haskell-Luevano

Long Chain Fatty Acid (LCFA) N-Acyl Derivatives of Melanocortin X-His-DPhe-Arg- Trp-NH2 Tetrapeptides: Potency and Selectivity Alteration at mMCR System

641

(2)

Aleksandar Todorovic, Jerry R. Holder, Rayna M. Bauzo, Joseph W. Scott and Carrie Haskell-Luevano

Structurally Related Peptides, Peptoids, and Peptide-Peptoid Hybrids: Comparison of Agonist Activity at the Melanocortin MC4 Receptor

643

(2)

Jerry Ryan Holder, Rayna M. Bauzo, Joseph W. Scott, Zhimin Xiang and Carrie Haskell-Luevano

A Novel AGRP-Melanocortin Peptide Chimeric Library

645

(2)

Krista R. Wilson, Andrzej M Wilczynski, Joseph W. Scott, Rayna M. Bauzo and Carrie Haskell-Luevano

Structural Requirements for the Human MC4 Receptor Selectivity of Novel Cyclic MT-II Analogues

647

(2)

Alexander V. Mayorov, So-Yeop Han, Matthew R. Hammer, Minying Cai, Dev Trivedi and Victor J. Hruby

Novel Ligands for Human Melanocortin Receptor Subtypes: Design, Synthesis and Structure-Activity Relationships

649

(2)

Magda Stankova, Minying Cai, Chris Cabello, Bridgette DeCot, Victor Krchnak Jr. and Victor J. Hruby

Novel a-MSH/γ-MSH Hybrid Analogues that Lead to Selective Ligands for the Human MC1R and Human MC3R

651

(2)

Minying Cai, Magda Stankova, Christopher Cabello, Bridgette Decot, Alexander Mayorov, Dev Trivedi, and Victor J. Hruby

Synthesis and Evaluation of Leu-Enkephalin Analogues Containing Substituted b-Turn Bicyclic Dipeptide Mimetics

653

(2)

Chiyi Xiong, Junyi Zhang, Jinfa Ying and Victor J. Hruby

Using Diverse Topographical and Conformational Privileged Structures to Explore Selectivity in Melanocortin Receptors

655

(2)

Victor J. Hruby, Preeti Balse-Srinivasan, Paolo Grieco, Guoxia Han, Minying Cai, Dev Trivedi, Alexander Mayorov, Jinfa Ying and Magda Stankova

Studies on Synthetic Analogs of the TM VI Segment of the MT1 Melatonin Receptor

657

(2)

Andrea Calderan, Paolo Ruzza, Barbara Biondi, Andrea Guiotto, Alessio Osler and Gianfranco Borin

Opioid Peptide Analogues: Conformation and Pharmacological Properties of Synthetic Dermorphin and Deltorphin 1 Peptide-Peptoid Hybrids

659

(2)

Laura Biondi, Elisa Giannini, Fernando Filira, Marina Gobbo, Mauro Marastoni, Lucia Negri, Barbara Scolaro, Roberto Tomatis and Raniero Rocchi

A Potent Cyclic Opioid Peptide Antagonist Lacking an N-terminal Amino Group

661

(2)

Grazyna Weltrowska, Yixin Lu, Carole Lemieux, Nga N. Chung and Peter W. Schiller

Dimerization of NPY-Receptors by Fluorescence Resonance Energy Transfer (FRET) in Living Cells

663

(2)

Annette G. Beck-Sickinger, Michaela Dinger, Robert Rennert, Ilka Böhme and Karin Mörl

Replacement of the Tic Residue by Benzo-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acids in TIPP Peptides

665

(2)

Sylvia Van Cauwenberghe, José Martins, Mylene Gosselin, Lejla Hodzic, Sylvain Caron, Joanne Butterworth and Dirk Tourwé

Synthesis, Purification, and Stabilization of a Myc/His Epitope Tagged Human d Opioid Receptor

667

(2)

Scott M. Cowell, Isabel Alves, Eva Varga, Tadashi Okura, Padma Nair, Henry I. Yamamura and Victor J. Hruby

Potent Antinociceptive Activity by a Novel Opioid, 3-(3'-Dmt-aminopropyl)-6-(4'-Dmt- aminobuty1)-5-methyl-2(1H)-pyrazinone

669

(2)

Yunden Jinsmaa, Yoshio Okada, Yuko Tsuda, Yusuke Sasaki, Akihio Ambo, Sharon D. Bryant and Lawrence H. Lazarus

ORL I Receptor Agonists and Antagonists

671

(2)

A.K. Judd, D.J. Tuttle, A. Kaushanskaya, R.W. Jones, A. Sanchez, W. Polgar, T. Khroyan and L. Toll

Bioactive N-terminal Undecapeptides Derived from Parathyroid Hormone: The Role of a-helicity

673

(2)

Alessandra Barazza, Nereo Fiori, Elisabetta Schievano, Stefano Mammi, Evaristo Peggion, Joseph M. Alexander, Michael Rosenblatt and Michael Chorev

Carboxy Terminal Modifications of PTH-(1-34) that Confer Skin Protease Resistance and Retain Biological Potency

675

(2)

Krishna G. Peri, Annie Bergeron, Thuy Lam, Kim High and Thierry Abribat

Synthesis of Conformationally Constrained PTH(1-14) Analogs

677

(2)

Ashok Khatri, Xiang-Chen Huang, Naoto Shimizu, and Thomas J. Gardella

Interactions of the Mid-Region of Parathyroid Hormone (1-34) with the Receptor Orient the Hormone for Receptor Activation

679

(3)

Angela Wittelsberger, Martina Corich, Byung-Kwon Lee, Alessandra Barazza, Dale F. Mierke, Michael Rosenblatt, and Michael Chorev

Hydrazide Linked Bifunctional Peptides for the Treatment of Pain

682

(2)

Yeon Sun Lee, Richard S. Agnes, Peg Davis, Shou-wu Ma, Josephine Lai, Frank Porreca and Victor J. Hruby

Assembly of High-Affinity Insulin Agonists and Antagonists from Peptide Building Blocks

684

(3)

Lauge Schäffer, Søren Østergaard, Jane C. Spetzler, Thomas Hoeg-Jensen, Jakob Brandt, Gillian M. Danielsen, Renuka C. Pillutla, Renee E. Brissette, Ulla Ribel, Asser S. Andersen and Neil I. Goldstein

Restoring a Functionally Important Loop in MAdCAM-1, the Primary Ligand of a4b7 Integrins

687

(2)

Gregory V. Nikiforovich and Garland R. Marshall

Synthesis of Membrane Active Peptides with a4b7-Helical Structure

689

(2)

Jyothi Thundimadathil, Lili Guo and Roger W. Roeske

Structure-Activity Relationships of a Novel Cyclic Dynorphin A Analog with Kappa Opioid Receptor Antagonist Activity

691

(2)

Matthew W. Leighty, Thomas F. Murray and Jane V. Aldrich

Multimeric Cyclic RGD Peptides with Improved Tumor Uptake for Tumor Targeting

693

(2)

G. Thumshirn, U. Hersel, T. Poethko, F. Rau, R. Haubner, M. Schwaiger, H.-J. Wester and H. Kessler

Conformational Study of Na+ Channel Inactivation Gate Peptides Interacting with Local Anesthetic Diphenyl Drugs Using NMR and Molecular Modeling

695

(3)

Bih-Show Lou, Ta-Hsien Lin and Chi-Zen Lou

Comparative Conformational Analysis of Neurokinin B and Selective NK3 Receptor Agonist.

698

(2)

Gulshen A Agaeva

Novel PACAP Analogs that Selectively Bind to PACAP-I Receptor

700

(2)

Jesse Z. Dong, Yeelana Shen, John E. Taylor, Michael Culler and Jacques-Pierre Moreau

N-Methylated Analogs of the Receptor-Binding Region of Human Parathyroid Hormone (hPTH)

702

(2)

Jean-René Barbier, Susanne MacLean, James F Whitfield and Gordon E Willick

Are Neuropeptides of the NPY Family Recognized from the Membrane-Bound State?

704

(3)

M Lerch, R. Bader and O. Zerbe

Chemical Synthesis of a Membrane Protein

707

(2)

Takeshi Sato, Yasuhiro Saito and Saburo Aimoto

Effect of RGD Peptides in In Vivo Model for Diabetic Retinopathy

709

(2)

Ralph-Heiko Mattern, Sergio Caballero, Amanda Omlor, Juerg F. Tschopp, Michael D. Pierschbacher and Maria B. Grant

Synthesis of Unusual RGD Cyclic Peptides Incorporating Cα-Fluoromethylamino Acids, as Selective Inhibitors of αv3β3 Integrin

711

(2)

Alma DalPozzo, Minghong Ni and Laura Muzi

Plasmon Waveguide-Resonance Spectroscopy: A New Method to Study GPCR Signal 'Transduction

713

(2)

Isabel D. Alves, Zdzislaw Salomon, Gordon Tollin, and Victor J. Hruby

Novel, Potent, ORL-1 Receptor Agonist Peptides Containing a-Helix Promoting Conformational Constraints

715

(2)

Chongwu Zhang, Paul R. Blake, Shen Shan, K. J. Valenzano and Donald J. Kyle

Synthesis and Pharmacological Activity of Novel Peptide Ligands for the NOP Receptor

717

(2)

Severo Salvadori, Remo Guerrini, Marina Zucchini, Giacomo Carrà, Daniela Rizzi, Domenico Regoli and Girolamo Calo

The Peptide Complementarity

719

(2)

Renata Zbozien-Pacamaj, Piotr Stefanowicz, Alicja Kluczyk, Marek Cebrat, Marek Lisowski and Ignacy Z. Siemion

The Superior Therapeutic Potential of SOM230 Originates from Unique Structural Elements

721

(2)

Ian Lewis, Wilfried Bauer, Rainer Albert, Nagarajan Chandramouli, Janos Pless, Gisbert Weckbecker and Christian Bruns

Sst4-selectivity is Induced by L-Configuration at Position 8 in Somatostatin (SRIF) Octapeptides

723

(2)

Judit Erchegyi, Sandra Wenger, Beatrice Waser, Jean-Claude Schaer, Renzo Cescato, Christy R.R. Grace, Carl Hoeger, Steven C. Koerber, Roland Rick, Jean Claude Reubi and Jean E. Rivier

Design of Oxytocin Antagonists that are Strikingly more Potent and Selective in Human Receptor Assays than Atosiban

725

(2)

LingLing Cheng, Stoytcho Stoev, Maurice Manning, Nga C. Wo, W.Y. Chan, Hazel H. Szeto, Thierry Durroux, Bernard Mouilbac and Claude Barberis

Design, Synthesis and Analysis of Single Chain Mimetics of Relaxin and Rclaxin-Like Factor (INSL3)

727

(2)

Mark P. Del Borgo, Richard A. Hughes and John D. Wade

Relaxin 3, a Novel Member of the Insulin Superfamily of Peptide Hormones

729

(3)

Ross A. Bathgate, Nicky F. Hanson, Feng Lin, Geoffrey W. Tregear and John D. Wade

Non-Peptidic ROD Mimetics for Stimulated Cell Adhesion on Biomaterials

732

(2)

C. Dahmen, Meyer, B. Jeschke, A. Enderle, S.L. Goodman, B. Nies and H. Kessler

Using Plasmon Waveguide Resonance (PWR) Spectroscopy to Directly Examine the Effects of Ligands on G-Protein Binding to Delta Opioid Receptors

734

(3)

Victor J. Itruhr, Isabel Alves, Zdzislaw Salamon and Gordon Tollin

Silylated Amino Acid Containing Substance P Analogues

737

(3)

F. Cavelier, D. Marchand, J. Martinez, S. Lavielle and S. Sagan

Synthesis and Pharmacological Activity of Human Urotensin II Analogues Modified in Position 8

740

(2)

Remo Guerrini, Girolamo Calo, Marina Zucchini, Valeria Camarda, Domenico Regoli and Severo Salvadori

Mapping the N-terminal Contact of Urotensin II with its Receptor Using Peptide Photoprobes

742

(2)

Brian J. Holleran, Antony A. Boucard, Adrian Häberli, Klaus Klarskov, Richard Leduc and Emanuel Escher

3D Structural Analysis of Urotensin-II Analogues in Membrane Mimetic Environment

744

(2)

Alfonso Carotenuto, Paolo Grieco, Pietro Campiglia, Ettore Novellino and Paolo Rovero

Development of New Urotensin-II Receptor Ligands

746

(2)

Pietro Campiglia, Alfonso Carotenuto, Riccardo Patacchini, Carlo A. Maggi, Ettore Novellino, Paolo Rovero and Paolo Grieco

Molecular Modeling of the Urotensin-II Receptor Complex

748

(2)

Paolo Grieco, Antonio Lavecchia, Pietro Campiglia, Teresa Lama, Paolo Rovero, Alfonso Carotenuto, Riccardo Patacchini, Carlo A. Maggi and Ettore Novellino

Structure-Activity Relationship and Bioactive Conformation of Prolactin Releasing Peptides (PrRPs), Ligand for a Potential Obesity Target

750

(2)

Waleed Danho, Joseph Swistok, Wajiha Khan, Theresa Truitt, Grazyna Kutylko, David Fry, David Greeley, Hongmao Sun, Mark Dvorozniak, Garry Mackie, Cheryl Spence and Robert Goodnow, Jr.

Synthesis and Conformational Behavior of the First Extracellular Loop Peptide of a GPCR

752

(2)

Sanjay K. Khare, Boris Arshava, Jeffery M. Becker and Fred R. Naider

Biosynthesis of the Sixth Transmembrane Domain of the Saccharomyces cerevisiae a- Factor Receptor

754

(2)

Racha Estephan, Enrique Arevalo, Jeffrey M. Becker and Fred Naider

Studies on the Cross-reactivity of Synthetic Oxytocin Receptors Prepared by Molecular Imprinting

756

(2)

Maria Kempe

Does a p-Cation Interaction Stabilize the Rhodopsin-Bound Conformation of Transducin's Alpha-Subunit?

758

(2)

Matthew A. Anderson, Rieko Arimoto, Wei Sha and Garland R. Marshall

Novel Peptide Therapeutic Approaches For Immune Tolerance

760

(5)

Stephanie D. Allen, Heike Bernert, Sharad V. Rawale, Anne M VanBuskirk and Pravin T.P. Kaumaya

Protein Aggregation Substrate/Inhibitor Structure-Function

Primary–Quaternary Structure Relationships Controlling Early Ab Oligomerization

765

(3)

Gal Bitan, Marina D. Kirkitadze, Hilal A. Lashuel, Sabrina S. Vollers and David B. Teplow

Conversion of a Natively Amyloidogenic Sequence into an Inhibitor of Amyloid Formation and Cytotoxicity Via Conformational Restriction

768

(3)

Aphrodite Kapurniotu, Andreas Buck, Marco Weber, Anke Schmauder, Thomas Hirsch, Jürgen Bernhagen and Marianna Tatarek-Nossol

Cu (II) Interaction with Amylin's Peptide Fragments

771

(2)

Angela Amoresano, Angela Flagiello, Giuseppe Impellizzeri, Antonio Magri, Giuseppe Pappalardo, Piero Pucci and Enrico Rizzarelli,

Inhibition of Amyloid Formation of Human Amylin

773

(2)

Dirk T.S. Rijkers, Jo W.M. Höppener, George Posthuma, Cornelis J.M. Lips and Rob M.J. Liskamp

Modulation of b-Amyloid 1-42 Aggregation by Other Aggregating Peptides

775

(2)

Lukasz P Frankiewicz and Aleksandra Misicka

Inhibition of β-Amyloid Aggregation with Cα,αDisubstituted Amino Acid Containing Peptides

777

(2)

Marcus A. Etienne, Jed P. Aucoin, Yanwen Fu, Robin L. McCarley and Robert P. Hammer

Amyloid-Like Fibrils of Laminin-1 Peptides

779

(3)

Motoyoshi Nomizu, Shingo Kasai, Yukiko Ohga, Mayumi Mochizuki, Masanori, Yamada, Yuichi Kadoya and Norio Nishi

Mass Spectrometric Elucidation of an Amyloid Plaque-specific Epitope: Molecular Basis for Probing the Proteolytic Mechanism of Alzheimer's Amyloid Precursor Protein

782

(3)

Michael Przybylski, Roxana Cecal, Xiaodan Tian , JoAnne McLaurin , Marilena Manea , Raluca Stefanescu and Peter St. George-Hyslop

Expression of a Synthetic Gene Encoding Human Transthyretin in Escherichia coli

785

(4)

Kimiaki Matsubara, Mineyuki Mizuguchi and Keiichi Kawano

Peptide Drug Delivery, Targeting And Biomaterials

Interactions between Lipid Bilayer and pH-Triggered Amphiphilic Peptides

789

(2)

Hsienming Lee and Jean Chmielewski

Application of Oligoarginine for the Delivery of Protein Complexes into Living Cells

791

(2)

Shiroh Futaki, Ikuhiko Nakase, Miki Niwa, Tomoki Suzuki, Daisuke Nameki, Ei-ichi Kodama, Masao Matsuoka and Yukio Sugiura

In Silico Investigation of LogP Parameters of Amino Acids and Peptides Tethered to C- Alkylated Sugar Bioconjugates

793

(2)

Piotr A Mroz, Florence M. Brunel, K. Grant Taylor and Arno F. Spatola

Are Alkylated C-Sugars Useful as Solubility Buffers?

795

(2)

Florence M. Brunel, Amit K. Galande, Piotr A. Mroz, K. Grant Taylor and Arno F. Spatola

Conformation and Bioactive Properties of Novel Osteoblast-Adhesive Peptides for Biomaterial Design

797

(3)

Manuela Vacatello, Gabriella D'Auria, Lucia Falcigno, Romina Oliva, Carmen Bevilacqua, Monica Dettin, Maria T. Conconi, Roberta Gambaretto, Carlo Di Bello and Livio Paolillo

Evolutionary Combinatorial Chemistry, a Novel Tool for SAR Studies on Peptide Transport across the Blood-Brain Barrier 1. Design, In Silico Validation and First Peptide Generation

800

(2)

Meritxell Teixidó, Ignmi Belda, Sonia González, Miriam Fabre, Senén Vilaró, Josep M. Garrett, Xavier Roselló, Fernando Albericio, and Ernest Giralt,

Structural Requirements for Non-Covalent Peptide-Mediated Cellular Delivery of siRNAs

802

(3)

Sébastien Deshayes, Nicole Van Mau, May C. Morris, Gilles Divita and Frédéric Heitz

Development of Bioavailable Water-Soluble Prodrugs of Peptidomimetics: Importance of the Conversion Time for Higher Gastrointestinal Absorption of Prodrugs based on Spontaneous Chemical Cleavage

805

(2)

Youhei Sohma, Yoshio Hayashi, Tomoko Ito, Hikaru Matsumoto, Tooru Kimura and Yoshiaki Kiso

Cyclic RGD-Peptides with Acidic-Anchors for Stimulated Cell Adhesion on Biomaterials

807

(2)

Jörg Auernheimer, Ulrich Hersel, Claudia Dahmen, Martin Kantlehner, Brigitte Jeschke, Anja Enderle, Berthold Nies, Simon L. Goodman and H. Kessler

Lipid and Carbohydrate Based Macromolecules in Drug and Vaccine Delivery

809

(2)

Istvan Toth. Aniko Horvath, Joanne Blanchfield, Colleen Olive, Michael Good, Norbert Wimmer and P. Elizabeth Rakoczy

Liposaccharides in Peptide Drug Delivery

811

(2)

Joanne Blanchfield, O. Paul Gallagher, Yasuko Koda, Paul Alewood, Richard Lewis and Istvan Toth

In Vivo Pharmacokinetic and Metabolic Studies of Peptide Drugs by MS and MS/MS

813

(2)

Reto Stöcklin, Philippe Favreau, Laure Menin, Philippe Bulet and Sophie Michalet

Peptide Targeting of Daunomycin into Sensitive and Multidrug Resistant Tumors

815

(3)

Ferenc Hudecz, Judit Reményi, Tamás Hegedus, Péter Kovács, Barbara Szabó, Balázs Sarkadi and Dezso Gaál

Characterization of Multicomponent Aggregate Containing a Bioactive Peptide and a Gd Complex

818

(2)

Antonella Accardo, Diego Tesauro, Paola Roscigno, Luigi Paduano, Eliana Gianolio, Giancarlo Morelli and Ettore Benedetti

Synthesis and Application of Functional Peptides for the Therapy of HPV Type 18 Positive Cervix Cancer Cells

820

(2)

Rüdiger Pipkorn, Klaus Braun, Waldemar Waldeck, Mario Koch and Jürgen Debus

Tat Peptide-Mediated Vectorization Of Nucleic Acids

822

(5)

Eric Vivès, Thibault Michel, Françoise Debart, Jean-Philippe Richard, Kamran Melikov, Leonid Chernomordik, Jean-JacquesVasseur and Bernard Lebleu

Peptide Combinatorial Libraries, Proteomics And Screening Methods

A Reassessment of the Role of Cys8 in Annexin A2-tPA Interaction

827

(2)

Oriol Roda, Mari-Luz Valero, Cristina Chiva, Sandra Peiró, Francisco X. Real, Pilar Navarro and David Andreu

Application of Topologically Segregated Bifunctional Beads to Construct Unique Combinatorial Bead Libraries

829

(2)

Xiaobing Wang, Li Peng, Ruiwu Liu and Kit S. Lam

Minimalism Applied To A Hit To Lead Program

831

(2)

Marc Vendrell, Rubén Ventura, Fernando Albericio, Rosario González-Muñiz, Laura Garcia de Diego, Cristina Carreño, A. Ferrer-Montiel, and Miriam Royo

Is it Possible to Minimize the Toxicity of a Hit Compound Without Reducing its Activity?

833

(2)

Rubén Ventura, Marc Vendrell, Fernando Albericio, Rosario González-Muñiz, Laura de Diego, Cristina Carreño, Antonio Ferrer-Montiel, and Miriam Royo

The Combined Solid and Solution-Phase Synthesis of Small Molecular Libraries: The Evolution of the "Libraries from Libraries" Concept

835

(2)

Yongping Yu, John M. Ostresh and Richard A. Houghten

Combinatorial Neoglycopeptide Arrays for the Study of Peptide Resistance to Proteolysis

837

(2)

Michael R. Carrasco, Matthew D. Bernardina, Ryan T. Brown and Katherine A. Rawls

Solid-Phase Synthesis of 1,3,4-Thiadiazolium-2-Aminides

839

(2)

Joseph C. Kappel, T. Scott Yokum and George Barony

Synthesis, Folding and Deconvolution of Combinatorial Peptide Libraries Based on a-Conotoxins: Generation of a Novel Ligand for α7 Nicotinic Acetylcholine Receptors

841

(2)

M. Ellison, J. Nielsen, B. Green, P. Buczek, M.J. McIntosh, B.M. Olivera and G. Bulaj

A Novel Encoding Method for "One-Bead One-Compound" Peptidomimetic and Small Molecule Combinatorial Libraries

843

(2)

Aimin Song, Jinhua Zhang, Carlito B. Lebrilla and Kit S. Lam

Characterizations of Peptides That Selectively Bind Neuroendocrine Differentiated Prostate Cancer Cells

845

(2)

Amanda M Enstrom and Kit S Lam

Increasing Diversity of One-bead One-compound Combinatorial Peptide Libraries Using Side-chain Derivatization

847

(2)

Ruiwu Liu and Kit S. Lam

A Novel Encoded High-Density Chemical Microarray Platform for Proteomics and Drug Development

849

(5)

Jan Marik, Qingchai Xu, Xiaobing Wang, Li Peng and Kit S. Lam

Highly Flexible Assembly of Large Peptide Arrays Using a Novel Fully Automated SPOT-Robot

854

(2)

Johannes Zerweck, Thomas Ast, Stefan Guffler, Karsten Schnatbaum and Holger Wenschuh

Peptide Libraries as a Tool for Studying Proteolytic Enzymes

856

(8)

Benjamin E. Turk and Lewis C. Cantley

Novel Tools And Applications In Parallel Peptides Synthesis

864

(2)

O.J Kreuzer, M Birringer, K. Zarse, J. Henkel, F. Bier, M Thürkand W. Zinsser

Design, Synthesis, and Study of Peptides Able to Recognize Hydrophilic Protein-Surface Patches

866

(3)

Marc Martinell, Xavier Salvatella, Ignasi Belda, Xavier Llorà, Jose J. Pastor, Marta Vilaseca, Margarida Gairi and Ernest Giralt

Chirality-Based Isotope Labeling in Library of Substrates (CHILLS) to Screen for Enzyme Preference by Mass Spectrometry

869

(4)

Laszlo Prokai, Stanley M. Stevens, Jr. and Katalin Prokai-Tatrai

Peptide Antibiotic, Anticancer, Antiviral and Antifungal Structure-Function

Membrane Binding and Antibacterial Activity of Cecropin-Mellitin Hybrid Peptides

873

(2)

Kalpana Bhargava and Jimmy B Feix

Interaction of Cationic Antimicrobial Peptides with Vesicles Mimicking the Outer Membrane of Gram-Negative Bacteria

875

(2)

Marina Gobbo, Laura Biondi, Fernando Filira, and Raniero Rocchi

Structure-Function Studies of Antimicrobial and Endotoxin Neutralizing Peptides

877

(2)

Sylvie E. Blondelle, Roman Jerala, Marta Lamata, Ignacio Moriyon, Klaus Brandenburg, Jörg Andrä, Massimo Porro and Karl Lohner

Fluorescent Analogs of Trichogin GA IV: A New Insight into the Mechanism of Membrane Permeabilization

879

(2)

Basilio Pispisa, Emanuela Gatto, Claudia Mazzuca, Antonio Palleschi, Lorenzo Stella, Mariano Venanzi, Fernando Formaggio and Claudio Toniolo

SAPD: Synthetic Antibiotic Peptides Database

881

(2)

David Wade and Jukka Englund

Generation of Novel Vancomycin–Type Glycopeptide Antibiotics by Mutasynthesis

883

(3)

Stefan Weist, Bojan Bister, Oliver Puk, Daniel Bischoff Stefan Pelzer, Wolfgang Wohllehen and Roderich D. Süssmuth

Solution Structure of an Anti fungal Peptide, Scarabaccin, from the Rhinoceros Beetle

886

(2)

Hikaru Hemmi, Jun Ishihashi, Tetsuya Tonne and Minoru Yamakawa

Small Analogues of Lysozyme with Antibacterial Properties

888

(2)

Xavier Daisy, Dan Ifrah, Trine S. Neerup and Paul R. Hansen

Effects of Glycine and Alanine Substitutions on Activity and Selectivity in Amphipathic β-Sheet Antimicrobial Peptides

890

(2)

Jack Blazyk, Yi Jin, Janet Hammer, Michelle Pate, Adam Bobbey, Jessica Mellinger and Erik Zmuda

Structure of Horseshoe Crab Antimicrobial Peptide, Tachyplesin I in Dodecylphosphocholine Micelles

892

(3)

Mineyuki Mizuguchi, Shinichi Kamata, Shun-ichiro Kawabata and Keiichi Kawano

From Innate Immunity to De Novo Designed Antimicrobial and Anticancer Diastereomeric Peptides

895

(5)

Yechiel Shai

Putative Intracellular Targets of the PR-rich Antimicrobial Peptide Bac7

900

(2)

Elena Podda, Marco Scocchi, Giuseppina Mignogna, Donatella Barra, Fulvio Micali, Andrea Mazzoli and Renato Gennaro

Pyrularia pubera Thionin: a Single Residue Mutation Enhances Antimicrobial Activity

902

(2)

Miguel Vila-Perelló, Andrea Sánchez-Vallet, Antonio Molina and David Andreu

Development of Orally Active Antibacterial Peptide Derivatives That Kill Resistant Urinary and Respiratory Tract Pathogens

904

(3)

Laszlo Otvos, Jr., Daniel J. Weiner, David E. Johnson and Mare Cudic,

Super Adhesive Peptides and Bacterial Adhesion

907

(2)

Yanlei Liu, Kit S. Lam, Xiaobing Wang, Ruiwu Liu, Frank Ventimiglia, and Joseph W. Leung

The Anti-HIV-1 Activity of Cyclic a-Defensins is Not Affected by Deleting Cystine

909

(2)

Hua Li, Qitao Yu, Jin-Long Yang and James P. Tam

Identification of T-Cell Epitopes Using SPOT-Synthesized Peptides

911

(2)

Mathias Streitz, Bernhard Aÿ, Florian Kern and Rudolf Volkmer-Engert

Approaches to the Reconstruction of a Discontinuous Binding Site

913

(2)

Judit Villén, Ricard A. Rodriguez-Mias, Ernest Giralt, Francisco Sobrino, and David Andreu

Inhibition of Antimicrobial Peptides by Exopolysaccharides of Lung Pathogens

915

(2)

Monica Benincasa, Maura Mattiuzzo, Yury Herasimenka, Paola Cescutti, Roberto Rizzo and Renato Gennaro

Structural Study of the HIV-1 gp160 Cleavage Site by Native and Modified Sequences: Role of Site Specific Mutations

917

(2)

Lucia Falcigno, Romina Oliva, Gabriella D'Auria, Massimiliano Maletta, Manuela Vacatello, Monica Dettin, A. Pasquato, Carlo Di Bello and Livio Paolillo

Structural Investigation of the HIV-1 Envelope Glycoprotein gp160 Cleavage Site: Solution Conformation of a 41-mer Peptide

919

(3)

Romina Oliva, Lucia Falcigno, Gabriella D'Auria, Diego Gargiulo, Monica Dettin, Antonella Pasquato, Carlo Di Bello and Livio Paolillo

Dendrimeric e-Peptides: A Novel Design of Antimicrobials

922

(2)

Qitao Yu, Chengwei Wu, Jin-Long Yang and James P. Tam

Membrane Permeable e-Peptides

924

(2)

Khee Dong Eom, Jin-Long Yang and James P. Tam

Structure-Activity Relationship Study of the Fragment 33-61 of a-Chain Bovine Hemoglobin

926

(2)

Alessandra Machado, Mauricio L. Sforça, Sirlei Daffre, Antonio Miranda, Alberto Spisni, Thelma A. Pertinhez and M. Terêsa M. Miranda

Conformational Studies of Gomesin Analogues

928

(2)

Marcos A. Fázio, Sirlei Daffre, M. Terêsa M Miranda and Antonio Miranda

Small 1- and d-Amino Acid Peptides Antagonize HIV-1 Replication

930

(3)

César Boggiano and Sylvie E. Blondelle

Structure-function Relationship of Peptide Analogues of Gaegurin 4, an Antimicrobial Peptide Isolated from a Korean Frog

933

(2)

Hyung-Sik Won and Bong-Jin Lee

Fragments of HIV GAG Polyproteins Expressing Affinity to Opioid Receptors

935

(3)

Andrzej W. Lipkowski, Piotr Kosson, Aleksandra Misicka, Daniel B. Carr, Victor J. Hruby, Masaaki Yoshikawa, Fanni Toth and Geza Toth

Dimeric Analogs of The Immunosuppressory Fragment of HLA-DR

938

(2)

Zbigniew Szewczuk, Monika Biernat, Marcin Dyba and Michal Zimecki

Indolicidin Analogs with Potent Antibacterial Activity

940

(2)

Trine S. Neerup, Xavier Doisy, Dan Ifrah and Paul R. Hansen

MS PepKit: The First Diagnostic Test to Follow-up Multiple Sclerosis

942

(3)

Anna M Papini, Barbara Mulinacci, Alfonso Carotenuto, Bruno Bonetti, Giuseppina Sabatino, Elisa Peroni, Francesca Nuti, Maria C. Alcaro, Maria C. Pozo-Carrero, Benedetta Mazzanti, Marta Pazzagli, Luca Massacesi, Luca Battistini, Mario Chelli, Paolo Rovero and Francesco Lolli

Structural Studies and Sequence Homology Investigations of the Guinea Pig Myelin Basic Protein (MBP) Epitope 74-85 Analogues

945

(2)

Andreas G. Tzakos, Patrick Fuchs, Nico A.J. van Nuland, Anastasios Troganis, Theodore Tselios, Spyros Deraos, George Deraos, Dimitrios Gatos, Ioannis P. Gerothanassis, Alexandre M.J.J. Bonvin and John Matsoukas

Peptide Strategies for Suppression of EAE

947

(2)

Stephanie D. Allen, Sharad V. Rawale, Caroline C. Whitacre and Pravin T.P. Kaumaya

The Temporin/VesCP (T/V)-Like Family of Bioactive Peptides

949

(3)

David Wade

Tissue Specific Peptide Pools: Fine Tuning of Cell Proliferation Rate in Cell Cultures and Tissues

952

(3)

Olga V. Sazonova, Elena Yu. Blishchenko, Konstantin V. Leontiev, S.V. Khaidukov, Evgeny Amchislaysky, Ella A. Starikova, Dmitry I. Sokolov, Irina S. Freidlin, Oleg N. Yatskin, Marina M. Philippova, Andrei A. Karelin and Vadim T. Ivanov

Metastin: Synthesis and Distribution in the Rat Medulla Oblongata and Spinal Cord

955

(6)

Jun Yang, G. Cristina Brailoiu, Siok L. Dun, Jaw-Kang Chang and Nae J. Dun

Peptide Dendrimer, Epitope and Vaccine Structure-Function

An Irreversible Inhibitor of a VIP-Hydrolyzing Antibody

961

(2)

Gita Bhatia, Yogesh Bangale, Hiroaki Taguchi, Robert Dannenbring, Stephanie Planque, Sangeeta Karle, Sudhir Paul and Yasuhiro Nishiyama

Bacterial and Mammalian Cell Penetration of Polycationic Antibacterial Peptides: Potential Utility as Drug Delivery Vehicles

963

(2)

Mare Cudic, Georgia Deliyannis, David C. Jackson and Laszlo Otvo Jr.

Synthetic Peptides in the Form of Dendrimers Retain Biological Activity and Become Resistant to Proteases

965

(3)

Luisa Bracci, Maria G De Montis, Chiara Falciani, Barbara Lelli, Luisa Lozzi, Paolo Neri, Alessandro Pini, Ylenia Runci and Alessandro Tagliamonte

Design and Synthesis of Porphyrin Centered Dendritic Poly(L-Lysine)

968

(2)

Louis A. Watanabe, Katsunori Kontani, Tamaki Kato and Norikazu Nishino

Property and Antibacterial Activity of Dendritic and Linear Cationic Peptides

970

(2)

Haruhiko Aoyagi, Akira Hirano, Takuro Niidome and Tomomitsu Hatakeyama

Introduction of Disulfide Bond Pairing into a TIER-2 B-Cell Epitope Improves Tumor Cell Binding and Antitumor Activities of Peptide Antibodies

972

(2)

Kenneth D. Lute, Naveen Dakappagari, Shard Rawale and Pravin T.P. Kaumaya

Conformational and Conserved Epitope of gp120 Exposed During Viral Fusion in HIV- Vaccine Design

974

(2)

Kristen Sadler, Yi-An Lu, Khee Dong Eom, Ying Zhang and James P. Tam

Multiepitope Analysis of the HIV-1 gp41-Specific Immune Response Using a Panel of Constrained and Unconstrained Peptides

976

(2)

Elisabetta Bianchi, David Opalka, Paolo Ingallinella, William Schleif, Michael McElhaugh, Renee Danzeisen, Romas Geleziunas, Michael Miller, Debra Eckert, David Bramhill, Joseph Joyce, James Cook, William Magilton, Gennaro Ciliberto, John Shiver, Mark Esser and Antonello Pessi

Structural Analysis of the Epitope of the Anti-HIV-1 mAb 2F5 Yields Insights into the Mechanism of Neutralization and into the HIV-1 Fusion Process

978

(3)

Antonello Pessi, Gaetano Barbato, Paolo Ingallinella, William H. Hurni, Michael D. Miller, Gennaro Ciliberto, Riccardo Cortese, Renzo Bazzo, John W. Shiver and Elisabetta Bianchi

Novel Design of Thiol-Containing Lactam-Bridge Constraints for Immune Presentation of the ELDKWAS Epitope from gp41 in the Type-I β-Turn Conformation Recognized by mAb 2F5

981

(2)

Yu Tian, Edward Arnold, Gail F. Arnold, and John W. Taylor

Induction of Protective CTL Responses in HLA-A*0201 Transgenic Mice against HTLV-1 Recombinant Vaccinia Virus Using a Multivalent CTL Epitope Peptide Construct

983

(2)

Roshni Sundaram, Sharad V Rawale, Naveen Dakappagari, Don Young, Christopher M Walker, Steven Jacobson and Pravin T.P. Kaumaya

Totally Synthetic Lipopeptides as Self-adjuvanting Contraceptive Vaccines

985

(2)

Weiguang Zeng, Yuk Fai Lau, Lorena E. Brown and David C. Jackson

The Matrix-Scan: A Micro Array of Peptide Constructs Mimicking Discontinuous Sites

987

(2)

Wim M.M. Schaaper, Jerry W. Slootstra, Wouter C. Puijk, Evert van Dijk, Johannes P.M. Langedijk, Rob H. Meloen and P. Timmerman

Synthetic Peptide Vaccine Strategies for the Enhancement of Cytotoxic T-Cell Responses

989

(2)

Naveen K. Dakappagari, Roshni Sundaram, Sharad Rawale, and Pravin T.P. Kaumaya

Effects of a Specific Peptide Bond Replacement on a Plasmodium falciparum Protein Primary Processing

991

(3)

José Manuel Lozano, Diana R. Tovar, Luz M Salazar, Marisol Ocampo, Fanny Guzmán and Manuel Elkin Patarroyo

Phosphorylated Antigenic Determinants of the La/SSB Autoantigen and Their Contribution as Potential Targets of the Autoimmune Response in Patients with Sjogren's Syndrome

994

(2)

Dimitrios Rokas, Eugenia Panou-Pomonis, Constantinos Sakarellos, Nicolas Coudevylle, Manh-Thong Cung, Athanassios G. Tzioufas, Haralampos M Moutsopoulos and Maria Sakarellos-Daitsiotis

Ligand Binder Arrays

996

(5)

Michael J Taussig

T Cell Immunogenecity of Synthetic Oligopeptides with 91-105 Epitope Core and Ala Flanks of 16 kDa Protein of Mycobacterium Tuberculosis

1001

(2)

Szilvia Bosze, Nadia Caccamo, Zsuzsa Majer, Francesco Dieli, Gábor Mezo and Ferenc Hudecz

Solubility and CTL Activity of Elongated Hydrophobic Peptide Epitopes

1003

(2)

Christine Klinguer-Hamour, Liliane Goetsch, Maryline Lokteff, Marie-Claire Bussat, Aline Blaecke, Alexandra Gonzales, Jean-François Haeuw, Nathalie Corvaia and Alain Beck

Identification of Potential Vaccine T Cell Epitopes Based on Computer Selected Sequences

1005

(2)

Leo Kei Iwai, Márcia Yoshida, M A. Shikanai-Yasuda, Maria A. Juliano, Jurgen Hammer, Luiz Juliano, Jorge Kalil, Luiz R. Travassos and Edecio Cunha-Neto

Structure-Activity Relationship Study of Glycopeptide Antigens Recognizing Specific Autoantibodics in Multiple Sclerosis

1007

(4)

Barbara Mulinacci, Francesca Nuti, Giuseppina Sabatino, Mario Chelli, Alfonso Carotenuto, Paolo Rovero, Benedetta Mazzanti, Marta Pazzagli, Francesco Lolli and Anna M. Papini

Author Index

1011

(10)

Subject Index

1021