Williams Hematology

Part I: Clinical Evaluation of the Patient

1: Approach to the Patient.

2: Examination of the Blood.

3: Examination of the Marrow.

Part II: General Hematology.

4: Structure of the Marrow.

5: Spleen and Other Lymphoid Tissues.

6: The Inflammatory Response.

7: Hematology of The Newborn.

8: Hematology in The Aged.

Part III: Molecular and Cellular Hematology.

9: Genetic Principles and Molecular Biology.

10: Cytogenetics and Gene Rearrangement.

11: Apoptosis.

12: Principles of Cell Regulation.

13: The Cluster of Differentiation (CD) Antigens.

14: Hematopoietic Stem Cells, Progenitor Cells, and Cytokines.

15: Immune Accessory Molecules and Signal Transduction.

Part IV: Therapeutic Principles.

16: Pharmacology and Toxicity of Antineoplastic Drugs.

17: Treatment of Infections in The Immunocompromised Host.

18: Allogeneic and Autologous Stem Cell Transplantation.

19: Gene Therapy.

20: The Use of Venous Access Devices.

21: Pain Management.

Part V: The Erythrocyte.

22: Morphology of The Erythron.

23: Composition of The Erythrocyte.

24: Iron Metabolism.

25: Metabolic Aspects of Folic Acid and Cobalamin.

26: Energy Metabolism and Maintenance of Erythrocytes.

27: The Red Cell Membrane

28: Structure and Function of Hemoglobin.

29: Production and Destruction of Erythrocytes.

30: Clinical Manifestations and Classification of Erythrocyte Disorders.

31: Aplastic Anemia.

32: Pure Red Cell Aplasia.

33: Anemia of Chronic Renal Failure.

34: Anemia of Endocrine Disorders.

35: The Congenital Dyserythropoietic Anemias.

36: Paroxysmal Nocturnal Hemoglobinuria.

37: The Megaloblastic Anemias.

38: Iron Deficiency.

39: Anemia Due to Other Nutritional Deficiencies.

40: Anemia Associated With Marrow Infiltration.

41: Anemia of Chronic Disease.

42: Disorders of Iron Transport and Storage.

43: Hereditary Spherocytosis, Elliptocytosis and Related Disorders.

44: Acanthocytosis, Stomatocytosis, and Related Disorders.

45: G 6 Phosphate Dehydrogenase Deficiency and Other Red Cell Enzyme Abnormalities.

46: The Thalassemias.

47: The Sickle Cell Diseases and Related Disorders.

48: Hemoglobinopathies Associated With Unstable Hemoglobin.

49: Methemoglobinemia and Other Causes of Cyanosis.

50: Traumatic Cardiac Hemolytic Anemia.

51: Microangiopathic Hemolytic Anemia.

52: March Hemoglobinuria, Sports Anemia, and Space Anemia.

53: Hemolytic Anemia Due to Chemical and Physical Agents.

54: Hemolytic Anemia Due to Infections With Microorganisms.

55: Acquired Hemolytic Anemia Due to Warm- Reacting Autoantibodies.

56: Cryopathic Hemolytic Syndromes

57: Drug- Related Immune Hemolytic Anemia.

58: Alloimmune Hemolytic Disease of the Newborn.

59: Acute Blood Loss Anemia.

60: Hypersplenism and Hyposplenism.

61: Polycythemia.

62: The Hematologic Aspects of Porphyria.

63: Hereditary and Acquired Sideroblastic Anemias.

Part VI: Neutrophils, Eosinophils, Basophils and Mast Cells.

64: Morphology of Neutrophils, Eosinophils, and Basophils.

65: Composition of Neutrophils. The Metabolism of Neutrophils

66: Production, Distribution, and Fate of Neutrophils.

67: Functions of Neutrophils.

68: Eosinophils and Their Disorders.

69: Production, Biochemistry, and Function of Basophils and Mast Cells. Basophilopenia, Basophilia, and Mastocytosis.

70: Classification and Clinical Manifestations of Neutrophil Disorders.

71: Neutropenia. and Neutrophilia.

72: Neutrophil Disorders: Qualitative Abnormalities of the Neutrophil.

Part VII: Monocytes and Macrophages.

73: Morphology of Monocytes and Macrophages.

74: Biochemistry and Function of Monocytes and Macrophages.

75: Production, Distribution, and Fate of Monocytes and Macrophages.

76: Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages.

77: Monocytosis and Monocytopenia.

78: Inflammatory and Malignant Histiocytosis.

79: Lipid Storage Diseases.

Part VIII: Lymphocytes and Plasma Cells.

80: Morphology of Lymphocytes and Plasma Cells.

81: Composition and Biochemistry of Lymphocytes and Plasma Cells.

82: Lymphoid Ontogeny and Homing Receptors.

83: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin.

84: Functions of T Lymphocytes: T-Cell Receptors for Antigen.

85: Functions of Natural Killer Cells.

86: Classification and Clinical Manifestation of Lymphocyte and....

87: Lymphocytosis and Lymphocytopenia.

88: Immunodeficiency Diseases.

89: Acquired Immunodeficiency Syndrome (AIDS).

90: Mononucleosis Syndromes.

Part IX: Malignant Diseases.

91: Classification of Myeloid Malignancies.

92: Myelodysplastic Disorders.

93: Acute Myelogenous Leukemia.

94: Chronic Myelogenous Leukemia and Related Disorders.

95: Idiopathic Myelofibrosis (Agnogenic Myeloid Metaplasia).

96: Classification of Malignant Lymphoid Disorders.

97: Acute Lymphocytic Leukemia.

98: Chronic Lymphocytic Leukemia and Related Diseases.

99: Hairy Cell Leukemia.

100: Large Granular Lymphocytic Leukemia.

101: Pathology of Malignant Lymphomas.

102: Hodgkin Disease.

103: Lymphomas.

104: Plasma Cell Neoplasms: General Considerations.

105: Essential Monoclonal Gammopathy.

106: Plasma Cell Myeloma.

107: Amyloidosis.

108: Macroglobulinemia.

109: Heavy- Chain Disease.

Part X: Hemostatasis and Thrombosis.

110: Megakaryopoiesis and Thrombopoiesis.

111: Platelet Morphology, Biochemistry and Function.

112: Molecular Biology, Biochemistry and Life- Span of Plasma... The Pathway of Blood Coagulation.

113: Control of Coagulation Reactions.

114: Vascular Function in Hemostasis.

115: Evaluation, Classification and Clinical Manifestations of Disorders of Hemos..

116: Molecular Mechanisms of Fibrinolysis.

117: Thrombocytopenia.

118: Thrombocytosis and Essential Thrombocythemia.

119: Hereditary Qualitative Platelet Disorders.

120: Acquired Qualitative Platelet Disorders Due to Disease, Drugs, and Foods.

121: The Vascular Purpuras.

122: Bleeding Disorders Due to Coagulation Factors II, V, VII, X, XI, XIII and Combined FV and VIII.

123: Hemophilia A and Hemophilia B.

124: Hereditary Abnormalities in Fibrinogen.

125: Coagulopathies Associated With Liver Disease, Liver Transplantation.

126: Disseminated Intravascular Coagulation.

127: The Inherited Thrombophilias.

128: Lupus Anticoagulants and Related Disorders.

129: Venous Thrombosis.

130: Thrombosis, Arteriosclerosis, and Coronary Artery Disease.

131: Antiplatelet Drugs and Therapy.

132: Oral Anticoagulants.

133: Heparin, Hirudin and Related Agents.

134: Fibrinolytic Therapy.

135: Von Willebrand Disease.

136: Disorders of Fibrinolysis and Use of Antifibrinolytic Agents.

Part XI: Transfusion Medicine.

137: Erythrocyte Antigens and Antibodies.

138: Human Leukocyte and Platelet Antigens.

139: Blood Procurement and Screening.

140: Preservation and Clinical Use of Erythrocytes and Whole Blood.

141: Collection and Transfusion of Leukocytes, Dendritic Cells, and Stem Cells.

142: Preservation and Clinical Use of Platelets.

143: Preparation and Clinical Use of Plasma and Plasma Fractions.

144: Therapeutic Hemapheresis: Indications, Efficacy, Complications.

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