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9780471252719

The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions

by ;
  • ISBN13:

    9780471252719

  • ISBN10:

    0471252719

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2001-09-01
  • Publisher: Wiley-Liss
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Summary

The rising number of incidences of melanoma has led to increased interest in the disease from diagnostic, management, and basic science perspectives. TheMelanocytic Proliferations describes the pathobiology of pigmented melanocytic lesions, and provides guidelines for their diagnosis and management as they affect the skin and mucosas. Extensively illustrated, this book is divided into four parts: the biology of melanocytes and malignant melanoma; nonmelanocytic lesions (e.g., lentigo, congenital nevi, compound nevi); melanocytic lesions with the potential to develop as melanoma (e.g., dysplastic nevi); and malignant melanoma (e.g., radial and vertical growth phases). Offering extensive discussions of each lesion,The Melanocytic Proliferations covers clinical applications, histology, differential diagnostic features, diagnostic algorithms, immunohistochemistry, electromicroscopy, and, where applicable, treatment, prognosis, and adjuvant therapy. The Melanocytic Proliferations is an excellent and indispensable resource for dermatologists, pathologists, dermapathologists, and surgical pathologists.

Table of Contents

Introduction xv
An Approach to the Clinical Diagnosis of Malignant Melanoma, Its Precursors, and Its Clinical Mimics
1(48)
Introduction
1(1)
Incidence
2(1)
Risk
2(1)
Precursors to Melanoma
3(1)
The Approach to the Patient
3(4)
The Initial Encounter
3(1)
History
4(1)
Physical Examination
4(2)
The Approach to the Individual Pigmented Lesion
6(1)
Summary
7(1)
Atlas of Clinical Lesions Correlating to Various Entities Discussed in the Text
7(42)
The Freckles and Lentigines
49(24)
Freckles (Ephelides)
49(1)
Lentigines: Lentigo Simplex and the Lentigionses
50(4)
Mucosal Lentigines
54(2)
Labial Melanotic Macule
54(1)
Genital Lentigines
54(1)
Vulvar and Penile Melanosis
55(1)
Acral Lentigines
56(1)
Melanotic Macule of the Nail Matrix
56(1)
Actinic (Solar) Lentigo
56(3)
Pigmented Actinic Keratoses
59(1)
PUVA-Induced Lentigines (PUVA Therapy/Tanning Beds/Xeroderma Pigmentosum)
59(1)
Large Cell Acanthoma
60(1)
Becker's Nevus
61(1)
Ink Spot Lentigo
62(1)
Melasma
62(1)
Albright's Syndrome
63(1)
The Cafe au Lait Macule
64(2)
Postinflammatory Hyperpigmentation
66(2)
References
68(5)
The Nondysplastic Acquired Nevi: Common Acquired Nevus and Other Benign Acquired Nevi
73(24)
Broad Overview of Clinical Features of the Common Acquired Nevus
73(3)
Broad Overview of the Histologic Features of the Common Acquired Nevus
76(1)
Histopathology of the Common Acquired Junctional Nevus
76(2)
Histopathology of the Common Acquired Compound Nevus
78(1)
Histopathology of the Common Acquired Dermal Nevus
78(3)
Other Acquired Benign Nevi
81(6)
Ballon Cell Nevus
81(4)
Cockarde Nevus
85(1)
Nevus Spilus
85(2)
Problematic Topics in the Realm of the Common Acquired Nevus
87(5)
Melanocytic Nevi with Focal Atypical Epithelioid Cell Components/Inverted Type A Nevus/Clonal Nevus
87(3)
Compound and Dermal Nevi with Mitotic Activity
90(1)
Effects of Exogenous or Endogenous Hormones on Nevocellular Nevi
90(2)
Differential Diagnosis of the Common Acquired Nevus and Its Distinction from the Dysplastic Nevus
92(1)
References
92(5)
The Dermal Dendritic Melanocytic Proliferations/Dermal Melanocytosis
97(24)
Introduction
97(1)
The Common Blue Nevus of Jadassohn-Tieche
97(7)
Epithelioid Blue Nevus
104(1)
Cellular Blue Nevus
105(7)
The Nevi of Ota and Ito
112(3)
The Mongolian Spot
115(2)
Sun's Nevus
117(1)
The Dermal Melanocyte Hamartoma
117(1)
References
118(3)
Spitz Nevus
121(62)
Introduction
121(1)
The Classical Compound Spitz Nevus
122(15)
Dermal Spitz Nevus and Its Nonmelanocytic Mimics: Neurothekeoma, Epithelioid Cell Histiocytoma, Plexiform Fibrohistiocytic Tumor, and Epithelioid Angiosarcoma
137(11)
Sclerosing or Desmoplastic Spitz Nevus/Desmoplastic Nevus
148(7)
Pagetoid Intraepidermal Spitz Nevus
155(1)
Pigmented Spindle Cell Nevus
155(6)
Pigmented Epithelioid Cell Nevus
161(1)
Plaque-Type Spitz Nevus
162(1)
Atypical Spitz Tumor
163(2)
Molecular and Immunohistochemical Studies as an Adjunct to Diagnosis of Spitz Nevus
165(11)
References
176(7)
Combined Nevus, Deep-Penetrating Nevus, and Plexiform Spindle Cell Nevus
183(12)
The Combined Nevus
183(3)
The Deep-Penetrating Nevus
186(6)
The Plexiform Spindle Cell Nevus
192(2)
References
194(1)
Recurrent Melanocytic Nevus
195(14)
Introduction and Clinical Features
195(1)
Histopathology
195(7)
Differentiation from Malignanat Melanoma with Regression and Recurrent Melanoma
202(5)
Grading Atypia in Recurrent Nevi
207(1)
References
207(2)
The Congential Nevus
209(16)
Introduction and Clinical Features
209(3)
Histology
212(5)
Proliferative Nodules in Congential Nevus
217(5)
Clinical Features
217(1)
Pathologic Features of Benign Proliferative Nodule
218(1)
Treatment
219(3)
References
222(3)
The Dysplastic Melanocytic Nevus, De Novo Intraepidermal Epithelioid and Lentiginous Melanocytic Dysplasia, and Nevi at Specific Anatomic Sites
225(56)
Dysplastic Melanocytic Nevus
225(13)
Incipient Junctional Dysplastic Nevus/De Novo Melanocytic Dysplasia of Lentiginous Type/Atypical Lentiginous Melanocytic Hyperplasia With Architectural Features of a Dysplastic Nevus
238(2)
Lentiginous Junctional and Compound Dysplastic Nevus
240(15)
De Novo Intraepidermal Epithelioid Melanocytic Dysplasia
255(2)
Nevomelanocytic Proliferations Peculiar to Specific Anatomic Sites
257(19)
The Vulvar Nevus
257(9)
The Acral Melanocytic Nevus
266(7)
The Halo Nevus
273(3)
References
276(5)
Malignant Melanoma
281(118)
Introduction
281(1)
Specific Subtypes of Malignant Melanoma
282(33)
Superficial Spreading Melanoma
282(2)
Histopathology of Radial Growth Phase-Confined Malignant Melanoma of Superficial Spreading Type
284(3)
Lentigo Maligna
287(18)
Acral Lentiginous Melanoma
305(5)
Mucosal Melanoma
310(5)
The Vertical Growth Phase of Malignant Melanoma
315(8)
Prognostication Including Microstaging of Malignant Melanoma
323(9)
Survival Based on Tumor Thickness for Malignant Melanoma
332(1)
Unusual Histologic and Clinical Variants of Malignant Melanoma
332(50)
Desmoplastic Melanoma
332(14)
Minimal Deviation Melanoma
346(2)
Spitzoid Melanoma
348(4)
A Summary of the Histopathologic Features of Minimal-Deviation Melanoma
352(1)
Nevoid Malignant Melanoma
353(2)
Equine/Animal-Type Melanoma in Humans: Malignant Melanoma with Prominent Pigment Synthesis
355(8)
Malignant Blue Nevus
363(1)
Malignant Melanoma with Concomitant Atypical Squamous Epithelial Cell Proliferations
364(2)
Metaplastic Change in Malignant Melanoma
366(2)
Baloon Cell Malignant Melanoma
368(1)
Metastatic Malignant Melanoma
369(2)
Myxoid Malignant Melanoma
371(4)
Signet Ring Cell Melanoma
375(1)
Small Cell Malignant Melanoma
375(3)
Malignant Melanoma in Childhood
378(3)
Other Rare Manifestations of the Morphological Diversity of Malignant Melanoma
381(1)
Other Malignant Superficial and/or Cutaneous Tumors of Neural Crest Origin
382(1)
References
382(17)
Conjunctival Melanocytic Proliferations
399(18)
Introduction
399(1)
Primary Acquired Melanosis
399(6)
Nevi of the Conjunctiva and Eyelid Skin
405(3)
Conjunctival Melanoma
408(4)
References
412(5)
The Use of Adjunctive Immunoperoxidase, Molecular, and Ultrastructural Studies in the Diagnosis of Melanocytic Proliferations
417(32)
Introduction
417(1)
The Melanosome/Premelanosome Associated Antigenic Markers: gp100, Melan-A/MART-1, Tyrosinase, MAGE-1/3, and gp75
418(11)
HMB-45
418(5)
Anti Melan-A/MART-1
423(2)
Tyrosinase
425(1)
MAGE
425(1)
Mel-5
425(1)
S100 Protein
426(1)
p75 Nerve Growth Factor Receptor
426(2)
Microphathalmia Transcription Factor (Mitf)
428(1)
Peripherin
429(1)
Type IV Collagen
429(1)
The Role of Molecular Adjuncts in Melanoma Diagnosis
429(6)
The Reverse Transcriptase Polymerase Chain Reaction as a Diagnostic and Prognostic Adjunct
429(4)
Molecular Diagnosis of Malignant Melanoma through Microarray Techniques
433(2)
The Role of the Electron Microscope in Melanoma Diagnosis
435(4)
The Ultrastructure of Common Malignant Melanoma
435(4)
Specturm of Different Forms of Melanosomes
439(1)
Premelanosomes and Aberrant Melanosomes
439(1)
References
439(10)
The Biology of Malignant Melanoma
449(28)
Introduction
449(1)
The Genetic Basic of Malignant Melanoma: Cell Cycle Dysregulation and the Malignant Phenotype
449(3)
p53, BCL-2, Fas, Telomerases and the Apoptotic Pathways
452(2)
The Oncogenes and Proto-Oncogenes
454(1)
Markers of Cell Proliferative Activity
455(2)
Ki-67/MIB-1 and PCNA
455(1)
The Agryophilic Nucleolar Organizer Region (AgNOR)
456(1)
Metallopanstimulin/S27 Ribosomal Protein
456(1)
Growth Factor Interdependence and Regulatory Pathways in Malignant Melanoma
457(1)
Cell-Matrix Interactions in Malignant Melanoma Progression
458(5)
Cell Surface Adhesion Molecules and Their Expression in Melanoma
458(3)
Cytoskeletal Components, Invasion, and the Metastatic Pathway
461(1)
The Matrix Metalloproteinases
462(1)
p75 Nerve Growth Factor Receptor
463(1)
Angiogenesis and the Metastatic Phenotype
463(2)
Vascular Endothelial Growth Factor and Intercellular Adhesion Molecule (ICAM)-1
463(1)
Basic Fibroblast Growth Facor (bFGF)
464(1)
Laminin Expression and Extravascular Migratory Metastasis
465(1)
CD40
465(1)
The Immune Response to malignant Melanoma
465(2)
References
467(10)
Approach to the Reporting of Equivocal/Borderline Nevomelanocytic Lesions: The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation as a Transition Step in Lesional Progression to malignant Melanoma
477(24)
Introduction
477(1)
The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation with Borderline Features of Radial Growth Phase Malignant Melanoma
478(1)
The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation with Borderline Features of Early Vertical Growth Phase Melanoma
479(1)
Severely Atypical Intraepidermal Epithelioid Cell Melanocytic Dysplasia---Is It Superficial Spreading Malignant Melanoma In Situ?
480(1)
De Novo Dermal Based Epithelioid Melanocytic Dysplasia
481(1)
The Atypical Lentiginous Melanocytic Proliferation/De Novo Melanocytic Dysplasia---Is It Lentigo Maligna?
481(1)
The Severely Atypical Dermal Based Melanocytic Proliferation That Does Not Fulfill Criteria for Designation as Nevoid Melanoma or Minimal-Deviation Melanoma of Spitzian Type
482(1)
The Severely Atypical Superficial Compound Spitz Tumor---Is It Superficial Spreading Malignant Melanoma Either in Radial or Early Vertical Growth Phase?
483(1)
The Severely Atypical Spitzian Proliferation---Is It Atypical Spitz Tumor or Spitzian Melanoma?
484(1)
Borderline Lesions Raising Consideration to Nevoid Melanoma
484(17)
The Therapy of Malignant Melanoma
501(22)
Surgical Therapy
501(1)
Excision of the Primary Lesion
501(1)
Elective Lymph Node Dissection
502(1)
Sentinel Lymph Node Biopsy
502(2)
Surgical and Pathologic Procedures
503(1)
Adjuvant Therapy of Melanoma
504(3)
Adjuvant Cytostatic Therapy
506(1)
Adjuvant Therapy with Combined Cytostatic and Immunotherapeutic Agents
506(1)
Therapy of Metastatic Melanoma
507(1)
Therapy of Regional Metastases
507(1)
Therapy for Distant Metastases
507(1)
Biologic Response Modifiers and Immunotherapy
508(1)
Specific Immunization Including Vaccination Strategies
509(2)
Radiation Therapy
511(1)
Therapy of Lentigo Maligna
511(1)
Therapy of Head and Neck Melanoma
512(1)
Cerebral Metastasis Therapy with Radiation
512(1)
References
513(10)
Appendix I: The TNM Staging Classification for Malignant Melanoma 523(2)
Appendix II: The Synoptic Report for Primary Cutaneous Malignant Melanoma 525(2)
Index 527

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