Stroke is a major cause of morbidity and mortality, with carotid disease representing an important contributory risk factor. This book is about the pathogenesis and management of carotid disease with specific focus on the role imaging has to play in the early recognition of symptomatic and asymptomatic disease as well as the treatment of the developed condition. Technological advances in imaging modalities now allow detailed analysis of the disease progression, the prediction of critical events leading to a stroke, as well as the identification of the most effective surgical or other interventional treatments. This book should be read by neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists involved in the care of patients with carotid disease, and also by researchers involved in the development of new therapeutic techniques and drugs.

Dedication
Abbreviations
Introduction Henry J. M. Barnett
1. Pathology of carotid artery atherosclerotic disease Renu Virmani, Allen Burke, Elena Ladich and Frank Kolodgie
2. Epidemiology of carotid artery atherosclerosis Christopher O'Donnell
3. Genetics of carotid atherosclerosis Stephen Rich and Donna Arnett
4. Haematological processes in emboli formation Alison Goodall and Greg McMahon
5. Medical treatment for carotid stenosis Matthew Giles and Peter Rothwell
6. Surgical management of symptomatic carotid disease: carotid endarterectomy and extracranial-intracranial bypass Jonathan Brisman and Marc Mayberg
7. Surgery for asymptomatic carotid stenosis Stella Vig and Alison Halliday
8. Interventional management of carotid disease Andrew Clifton
9. Conventional carotid Doppler ultrasound Gregory Moneta
10. Conventional digital subtraction angiography for carotid disease Jean Marie U-King-Im and Jonathan Gillard
11. Magnetic resonance angiography of the carotid artery Martin Graves, Jean Marie U-King-Im and Jonathan Gillard
12. Computed tomographic angiography of carotid artery stenosis Paul Nederkoorn, Charles Majoie and J. Stam
13. Cost-effectiveness analysis for carotid imaging Jean Marie U-King-Im, William Hollingworth and Jonathan Gillard
14. Morphological plaque imaging Chun Yuan and Tom Hatsukami
15. CT of the plaque Thomas de Weert, Mohamed Ouhlous, Marc van Sambeek and Aad van der Lugt
16. Assessment of carotid disease with ultrasound Stephen Meairs
17. Intravascular ultrasound Gaston Rodriguez-Granillo and Patrick Serruys
18. Image post-processing William Kerwin, Dongxiang Xu and Fei Liu
19. Nuclear imaging for the assessment of patients with carotid artery atherosclerosis John Davies and Peter Weissberg
20. USPIO - enhanced MR imaging of carotid atheroma Simon Howarth, Tjun Tang, Martin Graves, Rikin Trivedi, J. Harle and Jonathan Gillard
21. Gadolinium enhanced plaque imaging William Kerwin
22. Carotid magnetic resonance direct thrombus imaging Alan Moody
23. The proximal carotid arteries - image-based computational modelling X. Xu and Nick Wood
24. Mechanical image analysis using finite element method Tjun Tang, Chun Yang and Chun Yuan
25. Transcranial Doppler monitoring Michael Gaunt
26. MR and CT perfusion Jeroen van der Grond and Matthias van Osch
27. Near infrared spectroscopy in carotid endarterectomy Pippa Al-Rawi and Peter Kirkpatrick
28. Single photon emission computed tomography (SPECT) Kuniaki Ogasawara
29. Monitoring carotid interventions with Xenon CT H. Yonas and A. Carlson
30. Vascular imaging and the clinical development of new pharmaceuticals James Revkin and David Lester
31. Monitoring pharmaceutical interventions with conventional ultrasound (IMT) John Crouse
32. Monitoring pharmaceutical interventions with IVUS Stephen Nicholls, Steven Nissen and Murat Tuzcu
33. Monitoring of pharmaceutical interventions: MR plaque imaging Tom Hatsukami
34. Molecular imaging of carotid artery disease James Rudd, Michael Lipinski, Fabien Hyafil and Zahi Fayad
35. Future technical developments Brian Rutt and John Ronald.

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