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9780470574881

Evaluation of Drug Candidates for Preclinical Development : Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

by ; ;
  • ISBN13:

    9780470574881

  • ISBN10:

    0470574887

  • Format: eBook
  • Copyright: 2010-01-01
  • Publisher: Wiley
  • Purchase Benefits
List Price: $105.00
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Summary

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. This is an enlightening reference for scientists, medicinal chemists, and others working in drug discovery.

Table of Contents

Preface
ContributorS
Introduction
Pharmacokinetics In Preclinical Drug Development: An Overview
The Role Of Membrane Transporters In Drug Disposition
Cytochrome P450: Structure, Function, And Application In Drug Discovery And Development
The Role Of Drug Metabolism And Metabolite Identification In Drug Discovery
Protein Binding In Drug Discovery And Development
Prediction Of The Pharmacokinetics In Humans
Pharmaceutics Developability Assessment
Safety Assessment In Drug Discovery
Assessment Of Strategies Utilized To Minimize The Potential For Induction Of Acquired Long Qt Syndrome And Torsade De Pointes
Index
Table of Contents provided by Publisher. All Rights Reserved.

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