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9781444308471

Staphylococci in Human Disease, 2nd Edition

by ; ; ;
  • ISBN13:

    9781444308471

  • ISBN10:

    1444308475

  • Format: eBook
  • Copyright: 2009-10-01
  • Publisher: Wiley-Blackwell
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Summary

Staphylococci remain the most important cause of hospital-acquired infections in the U.S. and MRSA has become the most common cause of skin and soft tissue infection in many parts of the world.There is now a much greater understanding of the physiology and evolution of the staphylococci and this new edition reflects the rapid advancements in knowledge about this pathogen and provides a comprehensive review from both clinical and basic science perspectives.The first section addresses the basic biology of the staphylococci, their molecular genetics, host defenses and host evasion, virulence determinants, mechanisms of antibiotic resistance, and laboratory techniques. The second section deals with epidemiology, and the third section provides an overview of the varied clinical manifestations of human staphylococcal infections. The fourth section covers prevention and treatment of these often life-threatening infections.Written by experts from around the globe, this book is essential reading for all clinicians and basic scientists studying the staphylococci.

Table of Contents

The Organisms
Biology and Taxonomy
The biology of staphylococci
Genomics of the Staphylococci
The evolution and taxonomy of staphylococci
The molecular basis of pathogenicity
Adaptation to stress: biofilms and small colony variants
Exotoxins
Host Defense Against Staphylococcal Infection
The mechanism of host defense
Evasion of Host Defenses
Antimicrobial Resistance in Staphylococci
Resistance to beta-lactam antibiotics
Resistance to glycopeptides
Resistance to other agents
Laboratory Studies
Issues in the identification and susceptibility testing of staphylococci
Epidemiology of Staphylococcal Infection
Colonization with Staphylococcus aureus and the role of colonization in causing infection
Epidemiology of community-associated Staphylococcus aureus infections
Epidemiology of Healthcare-Associated Staphylococcus aureus Infections
Epidemiology of Coagulase-Negative Staphylococci and Infections Caused by these Organisms
Diseases Caused by Staphylococci
Staphylococcus Aureus Bacteremia and Endocarditis
Surgical Site Infections and Surgical Prophylaxis
Infections of Intravascular Catheters and Vascular Devices
Skin and soft tissue infections
Central nervous system infections
Diseases of the Eye
Osteomyelitis and Other Bone and Joint Infections
Staphylococcal Pneumonia
Urinary tract infections
Toxic Shock Syndrome
Toxin-mediated syndromes
Staphylococcal Diarrhea and Enterocolitis
Infections in Immunocompromised Patients
Clinical Manifestations of Community-Acquired MRSA Infections
Prevention and Treatment of Staphylococcal Infections
Elimination of S. aureus carriage: Importance and strategies
Treatment of Staphylococcal Infections
Vaccine-based strategies for prevention of Staphylococcus aureus infection
Index
Table of Contents provided by Publisher. All Rights Reserved.

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