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9780470391563

Cancer Stem Cells: Identification and Targets

by
  • ISBN13:

    9780470391563

  • ISBN10:

    0470391561

  • Format: eBook
  • Copyright: 2008-10-01
  • Publisher: Wiley-Interscience
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Summary

Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.

Table of Contents

Cancer Stem Cells (CSCs): Similarities and Variation of the Theme of Normal Stem Cells
Introduction
Stem cells in the life of an organism
Cancer Stem Cells (CSCs)
Self-renewal and differentiation in CSCs
CSC plasticity as regulated by intrinsic and extrinsic factors
Future Perspectives
Abbreviations
References
Leukemic Stem Cells
Introduction
Dysregulation of hematopoiesis in leukemia
Identification and isolation of Cancer Initiating Cell(s) in Leukemia
Molecular regulation of the aberrant hierarchies
Future Perspectives
Abbreviations
References
Isolation and Characterization of Breast and Brain Cancer Stem Cells
Introduction
Breast cancer Stem Cells
Brain Cancer Stem Cells
Conclusion
Abbreviations
References
Cancer Stem Cell Side Populations
Introduction
Stem cell side populations (SP)
SP in normal tissues
SP in tumors
Overcoming SP limitations
Conclusion and future perspectives
Abbreviations
References
Evidence for Cancer Stem Cells in Retinoblastoma
Introduction
Elusive Origins of Retinoblastoma
Sources of Retinoblastoma cells for study
Precedent for cancer stem cells
Side populations in Retinoblastoma
Immunoreactivity to stem cell markers in Retinoblastoma
Conclusion
Abbreviations
References
Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer Stem Cells
Introduction
Human ovary: An overview
Stem Progenitor Cells Exist In the Adult Mammalian Ovary
Is ovarian cancer a stem cell disease?
Abbreviations
References
Prostate Cancer Stem Cells
Introduction
The human prostate: biology, gland architecture and pathological alterations
Prostate epithelial stem cells
Prostate cancer stem cells
Stem cell tracking in the prostate
Conclusions and future directions
Abbreviations
References
Molecular Signatures of Highly Malignant Melanoma Stem Cells
General Properties of Human Melanomas
Characteristics of Stem Cell-derived Melanomas
The Cat Model System for Stem Cell Melanomas
Challenges of Research in Cancer Stem Cells and Therapeutics
Summary and Conclusions
Abbreviations
References
Invasion Program of Normal and Cancer Stem Cells
Introduction
The basics of tumor progression: invasion and metastasis
Epithelial to mesenchymal transitions in development and its relation to the invasive process
Regulation of EMT: from signals to molecular pathways
EMT and cancer stem cells
Can stem cell properties be extensive to invasive tumor cells?
Is there a unique EMT program linked to invasion?
Evidences of EMT in human clinical tumors
Expression of mesenchymal markers and cadherin switching in carcinomas
Expression of EMT inducers in human tumors
EMT may occur in a specific subset of breast carcinomas
Conclusions and perspectives
Abbre
Table of Contents provided by Publisher. All Rights Reserved.

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