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9781842142479

An Atlas of Differential Diagnosis in Neoplastic Hematopathology

by ; ;
  • ISBN13:

    9781842142479

  • ISBN10:

    184214247X

  • Format: Hardcover
  • Copyright: 2004-12-29
  • Publisher: Informa Healthc
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List Price: $379.95

Summary

This extensive reference covering neoplastic hematopathology includes over 500 colour illustrations depicting hematopoietic tumors involving lymph nodes, spleen, bone marrow, and commonly affected extranodal organs, with special emphasis on the differential diagnosis. It discusses basic clinical, prognostic, morphologic and phenotypic data, with numerous tables summarizing the phenotypic profiles of the most common hematologic tumors. A major feature of this book is an approach to hematologic tumors based on the WHO classification, with relevant examples and emphasis on the most useful morphologic and immunophenotypic features used in diagnosis.It will be an invaluable reference for all practising hematologists, oncologists and pathologists.

Table of Contents

Contributors x
Acknowledgments xi
Preface xii
Introduction
1(44)
General histologic and cytologic features
1(10)
Lymph node -- histology
1(2)
Bone marrow -- histology
3(2)
Lymph node -- cytology in histologic section
5(2)
Lymph node -- cytology in touch smear preparations
7(1)
Bone marrow -- cytology
7(4)
Peripheral blood -- cytology
11(1)
Introduction to immunohistochemistry
11(4)
Introduction to flow cytometry
15(14)
Flow cytometry of peripheral blood and bone marrow -- gating strategy
17(1)
Intensity of staining and co-expression of antigens
17(1)
Polyclonal versus monoclonal B-cell populations
18(2)
Prognostic markers
20(1)
Aberrant expression of antigens
20(1)
Differential diagnosis of mature B-cell lymphoproliferative disorders
21(3)
Identification of abnormal T-cells by flow cytometry
24(3)
Mature T-cell disorders versus precursor T-lymphoblastic lymphomalleukemia
27(2)
Differential diagnosis of acute leukemias
29(1)
Introduction to cytogenetics/molecular pathology
29(1)
Normal structure of hematolymphoid organs
30(5)
Lymph node
30(2)
Bone marrow
32(2)
Spleen
34(1)
Approach to the diagnosis of hematopoietic tumors
35(1)
WHO classification of hematopoietic tumors
35(10)
Mature B-cell neoplasms
45(72)
Chronic lymphocytic leukemia/small lymphocytic lymphoma
45(3)
B-cell prolymphocytic leukemia
48(1)
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia
49(7)
Marginal zone B-cell lymphoma
56(8)
Splenic marginal zone B-cell lymphoma
56(4)
Nodal marginal zone B-cell lymphoma
60(1)
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
60(4)
Hairy cell leukemia
64(3)
Plasma cell neoplasms
67(12)
Follicular lymphoma
79(9)
Mantle cell lymphoma
88(4)
Diffuse large B-cell lymphoma
92(16)
Mediastinal large B-cell lymphoma
108(1)
Intravascular large B-cell lymphoma
108(1)
Primary effusion lymphoma
108(1)
Burkitt lymphoma
108(6)
Lymphomatoid granulomatosis
114(3)
Mature T-cell lymphoproliferative disorders
117(40)
T-cell prolymphocytic leukemia
117(6)
Large granular lymphocyte leukemia
123(2)
Adult T-cell lymphoma/leukemia
125(1)
Extranodal NK/T-cell lymphoma, nasal type
125(3)
Enteropathy-type T-cell lymphoma
128(2)
Hepatosplenic T-cell lymphoma
130(1)
Subcutaneous panniculitis-like T-cell lymphoma
130(3)
Mycosis fungoides and Sezary syndrome
133(2)
Primary cutaneous anaplastic large cell lymphoma
135(1)
Peripheral T-cell lymphoma, unspecified
136(10)
Angioimmunoblastic T-cell lymphoma
146(1)
Anaplastic large cell lymphoma
147(8)
Lymphomatoid papulosis
155(2)
Hodgkin lymphoma
157(18)
Classification of Hodgkin lymphoma
157(1)
Nodular lymphocyte-predominant HL
157(7)
Classical HL
164(11)
Nodular sclerosis HL
164(1)
Lymphocyte-rich classical HL
165(1)
Mixed cellularity HL
165(1)
Lymphocyte-depleted HL
166(1)
Extranodal involvement of classical HL
167(8)
Chronic myeloproliferative disorders
175(16)
Classification and general diagnostic criteria of CMPD
175(1)
Morphology
175(1)
Cytogeneticslmolecular tests
175(1)
Immunophenotyping
176(1)
Chronic myelogenous leukemia
176(6)
CML, chronic phase
177(2)
CML, accelerated phase
179(1)
CML, blast crisis
180(2)
Chronic eosinophilic leukemia/hypereosinophilic syndrome
182(1)
Polycythemia vera
182(1)
Chronic idiopathic myelofibrosis
183(1)
Essential thrombocythemia
184(1)
Differential diagnosis of CMPD
184(7)
Myelodysplastic/myeloproliferative diseases
191(4)
Chronic myelomonocytic leukemia
191(3)
Myelodysplastic/myeloproliferative disease, unclassifiable
194(1)
Myelodysplastic syndromes
195(12)
Introduction
195(1)
Morphologic features
195(3)
Phenotypic features (flow cytometry)
196(2)
Cytogenetics
198(1)
Refractory anemia
198(2)
Refractory anemia with ringed sideroblasts
200(1)
Refractory cytopenia with multilineage dysplasia
200(1)
Refractory anemia with excess blasts
200(1)
5q(-) syndrome (del(5q) syndrome)
200(2)
Differential diagnosis of MDS
202(5)
Acute myeloid leukemia
207(30)
Introduction
207(2)
General morphologic features
207(2)
Phenotypic features of acute leukemias
209(1)
AML with t(8;21)(q22;q22) (AML1/ETO)
209(1)
AML with inv(16)(p13q22) or t(16;16)(p13;q22)
209(1)
Acute promyelocytic leukemia (APL, AML-M3; AML with t(15;17)(q22;q12))
209(7)
Acute myeloid leukemia (AML-M0, M1 and M2)
216(2)
Acute myelomonocytic leukemia (AML-M4)
218(1)
Acute monocytic leukemia (AML-M5)
219(3)
Acute erythroid leukemia (AML-M6)
222(3)
Acute megakaryoblastic leukemia (AML-M7)
225(1)
Acute basophilic leukemia
225(1)
Differential diagnosis of AML
225(2)
Extramedullary myeloid tumor
227(1)
Biphenotypic acute leukemia
227(10)
Precursor neoplasms
237(14)
Precursor B-lymphoblastic leukemia/lymphoma
237(3)
Precursor T-lymphoblastic lymphoma/leukemia
240(11)
Thymocytes versus precursor T-lymphoblastic lymphoma
240(4)
Blastic NK-cell lymphoma (DC2 acute leukemia)
244(7)
Histiocytic and dendritic cell tumors
251(6)
Histiocytic sarcoma
251(1)
Langerhans cell histiocytosis
252(3)
Follicular dendritic cell sarcoma
255(2)
Mastocytosis
257(4)
Composite hematolymphoid tumors
261(8)
Differential diagnosis - morphology
269(30)
Vacuolated cells
269(1)
Lymph node with diffuse small lymphocytic infiltrate
269(1)
Lymph node with diffuse, mixed small, medium-sized and large cell infiltrate
269(1)
Lymph node with diffuse large cell infiltrate
269(1)
Lymph node with nodular infiltrate
269(1)
Lymph node with paracortical/interfollicular infiltrate
270(1)
Lymph node with blastic/blastoid infiltrate
270(1)
Lymph node with starry-sky pattern
270(1)
Lymph node with clear cell infiltrate
270(1)
Large cell infiltrate with anaplastic features
270(1)
Lymphoid infiltrate with large multilobated (multinucleated) cells with prominent nucleoli
270(1)
Lymphoid infiltrate with numerous histiocytes
270(1)
Lymph node with plasma cell/plasmablastic infiltrate
270(1)
Bone marrow with large cell infiltrate
270(1)
Bone marrow with atypical megakaryocytosis
271(1)
Bone marrow with reactive lymphoid aggregates
271(1)
Bone marrow with nodular lymphoid infiltrate
271(1)
Bone marrow with paratrabecular lymphoid infiltrate
271(1)
Bone marrow -- discrepancy between the size of lymphocytes in primary lymphoma and the bone marrow involvement
271(1)
Bone marrow with diffuse lymphoid infiltrate
271(1)
Bone marrow -- patterns of involvement by mature T-cell lymphoproliferative disorders
271(1)
Bone marrow with intrasinusoidal lymphoid infiltrate
271(1)
Bone marrow with non-hematopoietic tumors
271(28)
Differential diagnosis -- phenotype
299(40)
ALK-1+ neoplasms
299(1)
Bcl-1+ neoplasms
299(1)
Bcl-6+ neoplasms
299(1)
CD4:CD8 ratio
299(1)
CD5+ neoplasms
300(1)
CD10 expression
300(1)
CD15 expression
300(1)
CD20+ neoplasms
300(1)
CD20- B-cell neoplasms
300(1)
CD21 expression in hematolymphoid neoplasms
300(1)
CD23 expression
300(1)
CD25+ neoplasms
301(1)
CD30+ expression
301(1)
CD45- hematopoietic neoplasms
301(1)
CD45 versus side scatter -- flow cytometric gating strategy
301(1)
CD45 versus side scatter -- pattern recognition in flow cytometry analysis
301(1)
CD56+ neoplasms
301(1)
CD103+ neoplasms
301(1)
CD117+ neoplasms
301(1)
EBV/EBER expression
302(1)
Epithelial membrane antigen (EMA) expression
302(1)
TCRγδ+ neoplasms
302(1)
HHV-8+ lesions
302(1)
Ki-67 (MIB-1) expression
302(1)
Pax-5 expression
302(37)
Differential diagnosis -- localization
339(40)
Body cavity
339(1)
Lung
339(1)
Mediastinum
339(1)
Salivary gland
339(1)
Skin
339(1)
Spleen
339(1)
Stomach
340(1)
Small and large intestine
340(39)
References 379(24)
Abbreviations 403(2)
Index 405

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