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9789810225711

PRIMER OF CHEMICAL PATHOLOGY, A

by ; ; ; ;
  • ISBN13:

    9789810225711

  • ISBN10:

    9810225717

  • Format: Nonspecific Binding
  • Copyright: 1996-02-09
  • Publisher: World Scientific Publishing
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Table of Contents

Preface v
Acknowledgement v
Sodium and Water Metabolism
1(24)
Osmolality
1(1)
Water homeostasis
2(5)
Sodium homeostasis
7(2)
Sodium depletion
9(1)
Sodium excess
10(2)
Water deficiency
12(2)
Water excess
14(2)
Disorders of the serum sodium
16(4)
Hypernatraemia
16(2)
Hyponatraemia
18(2)
Disorders of renal water excretion
20(5)
Polyuria
20(3)
Oliguria
23(2)
Potassium
25(10)
Homeostasis
25(2)
Hyperkalaemia
27(3)
Isemia
30(5)
Acid-Base and Blood Gases
35(27)
Definitions
35(1)
Acid-base homeostasis
36(1)
Hydrogen ion metabolism
36(1)
Carbon dioxide metabolism
36(4)
Disturbances of acid-base regulation
40(10)
Metabolic acidosis
41(2)
Metabolic alkalosis
43(2)
Respiratory acidosis
45(2)
Respiratory alkalosis
47(1)
Mixed disturbances
48(2)
Evaluation of acid-base disorders
50(3)
Oxygen metabolism
53(2)
Abnormalities of the Po2
55(4)
Renal H+ excretion:
The modern view
59(1)
The alternative view
60(2)
Mineralocorticoids
62(10)
Normal physiology
62(4)
Aldosterone
62(1)
The renin-angiotensin system
62(4)
Mineralocorticoid excess syndromes
66(3)
Mineralocorticoid deficiency syndromes
69(3)
The Kidney and Renal Disease
72(16)
Normal physiology
72(3)
Concept of clearance
75(1)
Fractional excretion
76(1)
Chronic renal failure
76(2)
Acute renal failure
78(2)
Renal tubular disorders
80(3)
Renal tubular acidoses
81(2)
Proteinuria
83(2)
Nephrolithiasis
85(3)
Calcium
88(15)
Homeostasis
88(4)
Hypercalcaemia
92(5)
Hypocalcaemia
97(2)
Bone disease
99(2)
Markers of bone turnover
101(2)
Phosphate
103(5)
Homeostasis
103(2)
Hyperphosphataemia
105(1)
Hypophosphataemia
106(2)
Magnesium
108(6)
Normal metabolism
108(1)
Hypomagnesaemia
109(2)
Hypermagnesaemia
111(3)
Urate and Gout
114(8)
Purine metabolism
114(1)
Urate metabolism
114(2)
Inborn errors of purine metabolism
116(1)
Hyperuricaemia
116(5)
Gout
118(3)
Hypouricaemia
121(1)
Glucose, Lactate & Ketones
122(21)
Glucose metabolism
122(2)
Carbohydrate digestion and absorption
124(1)
Hormones regulating carbohydrate metabolism
125(1)
Hyperglycaemia
126(7)
Diabetes mellitus
126(5)
Laboratory evaluation
131(2)
Hypoglycaemia
133(3)
Laboratory evaluation
135(1)
Ketogenesis
136(3)
Lactic acid metabolism
139(4)
The Hepatobiliary System
143(19)
Bilirubin metabolism
143(3)
Hepatobiliary disease
146(10)
Jaundice
147(1)
Hepatocellular disease
148(2)
Cholestatic disease
150(3)
Infiltrations
153(1)
Cirrhosis
153(1)
Alcoholic liver disease
154(1)
Drug-induced liver disease
155(1)
Fatty liver
155(1)
Laboratory evaluation
156(6)
Routine liver function tests
156(3)
Specific aetiological tests
159(3)
Plasma and CSF Proteins
162(15)
Plasma proteins
162(1)
Plasma proteins in health and disease
163(2)
Albumin
165(2)
The immunoglobulins
167(3)
Polyclonal hypergammaglobulinaemia
170(1)
Monoclonal hypergammaglobulinaemia
170(4)
The acute phase proteins
174(1)
CSF proteins
175(2)
Enzymes in Diagnosis
177(14)
Enzymes of clinical import
178(9)
Alkaline phosphatase
178(3)
5'-Nucleotidase
181(1)
Acid phosphatase
181(1)
Prostate specific antigen
181(1)
α-Amylase
181(1)
Aspartate aminotransferase
182(1)
Alanine aminotransferase
183(1)
Gamma-glutamyl transferase
183(1)
Creatine kinase
184(1)
Lactate dehydrogenase
185(2)
Cholinesterase
187(1)
Angiotensin converting enzyme
187(1)
Conditions associated with abnormal enzyme profiles
187(4)
Plasma Lipids & Lipoproteins
191(21)
Plasma lipids
191(2)
Plasma lipoproteins
193(2)
Plasma apolipoproteins
195(2)
Lipoprotein metabolism
197(4)
Lipids and cardiovascular disease
201(3)
Investigation of the hyperlipidaemic patient
204(4)
Primary/secondary hyperlipidaemia
208(2)
The hypolipoproteinaemias
210(2)
The Gastrointestinal Tract
212(12)
Gastric function
212(1)
Pancreatic function
212(2)
Intestinal function
214(2)
Endocrine aspects of the gut
216(1)
Disorders of GIT function
217(3)
Laboratory evaluation of the malabsorption syndromes
220(2)
GIT hormone-secreting tumours
222(2)
The Hypothalamus and Pituitary Gland
224(9)
The hypothalamic hormones
224(1)
The pituitary hormones
225(4)
Disturbed function
229(4)
The Thyroid Gland
233(14)
Normal metabolism
233(2)
Autoimmune thyroid disease
235(1)
Thyrotoxicosis
236(3)
Hypothyroidism
239(3)
The sick euthyroid syndrome
242(1)
Drugs and the thyroid
242(1)
Thyroid function tests
243(4)
The Adrenal Cortex
247(15)
Normal physiology
247(3)
Congenital adrenal hyperplasias
250(1)
Hypocortisolism
251(6)
Hypercortisolism
257(5)
Reproductive Endocrinology
262(9)
Normal physiology
262(2)
Fetal sexual development
264(1)
Puberty
264(1)
The menstrual cycle
265(1)
Pregnancy
266(1)
Lactation
267(1)
Menopause
267(1)
Reproductive disorders
267(1)
Hypogonadism
267(1)
Amenorrhoea
268(1)
Hypergonadism
269(1)
Hirsutism and virilism
269(2)
Iron
271(7)
Homeostasis
271(3)
Iron deficiency
274(2)
Iron overload
276(2)
Porphyrins
278(6)
Haem synthesis and porphyrins
278(1)
Porphyrias
279(2)
Lead poisoning
281(1)
Laboratory evaluation of porphyrias
282(2)
Biochemical Syndromes of Tumours
284(7)
Diagnosis of cancer
284(1)
Tumour markers
285(6)
Amines
286(1)
Hormones
286(2)
Enzymes
288(1)
Proteins
289(2)
Biochemical Aspects of Hypertension
291(6)
Causes and pathophysiology
291(1)
Laboratory evaluation
292(3)
Catecholamines and phaeochromocytoma
295(2)
Inherited Metabolic Diseases
297(14)
Types of inheritance
297(1)
Inherited metabolic diseases
297(9)
Laboratory evaluation
306(1)
Prenatal diagnosis of carrier status
307(1)
Molecular testing
308(3)
Nutrition, Vitamins, Trace Elements
311(9)
Assessment of nutritional status
311(1)
Carbohydrates
312(1)
Fats
312(1)
Proteins
312(2)
Vitamins
314(4)
Trace metals
318(2)
Pregnancy, Prenatal Diagnosis and Infertility
320(10)
Pregnancy: metabolic changes
320(1)
Feto-placental unit
321(2)
Biochemical monitoring during pregnancy
323(2)
Prenatal diagnosis of fetal defects
325(2)
Laboratory evaluation of infertility
327(3)
Paediatric Chemical Pathology
330(14)
Renal function and electrolytes
330(3)
Calcium, phosphate, magnesium
333(1)
Glucose homeostasis
334(3)
Liver function
337(3)
Plasma proteins
340(1)
Ammonia
341(3)
Therapeutic Drug Monitoring and Toxicology
344(10)
Therapeutic drug monitoring
344(5)
Anticonvulsants
347(1)
Antibiotics
348(1)
Cardiovascular drugs
348(1)
Psychotropic drugs
348(1)
Bronchodilators
349(1)
Drug overdose and toxicology
349(1)
Evaluation of the unconscious patient
349(1)
Paracetamol
350(1)
Salicylates
351(1)
Ethanol
351(3)
Abbreviations 354(2)
Index 356(34)
Index of Tables 390(2)
Index of Figures 392

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