RNA Interference

RNAi is a revolution in biology, representing a breakthrough in understanding how genes are regulated in cells, and a completely new approach to drug discovery and development. RNAi offers the opportunity to harness a natural mechanism to develop specific and potent medicines, and has the potential to become the foundation for a whole new class of therapeutic products. This book, written by leading researchers in the field, covers selection of siRNA, screening for the active molecules, general considerations in introducing chemical modifications, as well as discussing formulations used to deliver siRNA and applications of RNAi in many exciting therapeutic areas. These are exciting times for RNAi therapeutics, with important scientific and clinical advancements being made at a very rapid pace. The discovery of RNAi has been widely acknowledged as a major breakthrough in biology, and the belief that this technology has the potential to make a broad and significant impact in medicine is stronger than ever. The authors' research is part of the effort in translating the science of RNAi into a robust drug discovery capability, with the goal of building a sustainable product pipeline of innovative medicines. The book reflects their role in this cutting area of R&D.