Nutrition Research Methodologies

A new book in the acclaimed Nutrition Society Textbook Series, Nutrition Research Methodologies addresses the rapidly advancing field of nutrition research. It covers the diverse methodologies required for robust nutritional research to ensure thorough understanding of key concepts, both for students at undergraduate and postgraduate levels and for scientists working in nutrition research.

Combining theory with practical application, Nutrition Research Methodologies addresses both traditional research methods and new technologies, and focuses on a range of complex topics, including energy compensation, nutrient-gene interactions and metabolic adaptation. It also considers statistical issues as well as application of data to policy development.

• Provides the reader with the required scientific basics of nutrition research in the context of a systems and health approach
• Written specifically to meet the needs of individuals involved in nutrition research
• Combines the viewpoints of world-leading nutrition experts from academia and research with practical applications
• Accompanied by a companion website with a range of self-assessment material (www.wiley.com/go/lovegrove/nutritionresearch)

Professor Julie A Lovegrove, Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular Research, Department of Food and Nutritional Sciences, University of Reading, UK.

Associate Professor Leanne Hodson, Oxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, UK.

Professor Sangita Sharma, Centennial Professor, Endowed Chair in Aboriginal Health, Professor of Aboriginal & Global Health Research, Aboriginal and Global Health Research Group, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Canada.

Professor Susan A Lanham-New, Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, UK.

Contributors vii

Series Foreword ix

Preface x

About the Companion Website xii

1 Nature, Purpose and Implications of Research in Nutrition 1
Alan A Jackson, Stephen A Wootton and Martin Wiseman

2 Study Design: Population-Based Studies 13
Janet Cade and Jayne Hutchinson

3 Study Design: Intervention Studies 28
Jayne V Woodside, Robert W Welch, Chris C Patterson and Michelle C McKinley

4 Methods to Determine Dietary Intake 48
Nadia Slimani, Heinz Freisling, Anne-Kathrin Illner and Inge Huybrechts

5 Food Composition 71
Barbara Burlingame and U Ruth Charrondiere

6 Biomarkers of Intake 90
Gunter G C Kuhnle

7 Methods of Data Analysis 108
Graham Horgan

8 Considerations for Including Different Population Groups in Nutrition Research 123
Maria J Maynard

9 Use of Biobanks in Nutrition Research 141
Kurt Zatloukal, Pieter van’t Veer, Christian Viertler, Marc-Jeroen Bogaardt and Peter Hollman

10 Methods Investigating Food-Related Behaviour 151
Moira Dean, Monique M Raats and Liisa Lähteenmäki

11 Methods for Assessing Nutritional Status and Body Composition 169
Peter Murgatroyd, Les Bluck and Laura Watson

12 Energy Expenditure and Intake Methods 186
Klaas R Westerterp

13 Application of ‘Omics’ Technologies 198
Helen M Roche, Baukje de Roos and Lorraine Brennan

14 Epigenetics 212
John C Mathers

15 Nutrient–Gene Interactions 225
Anne Marie Minihane

16 Data Analytical Methods for the Application of Systems Biology in Nutrition 235
Corrado Priami and Melissa J Morine

17 Stable Isotopes in Nutrition Research 250
Margot Umpleby and Barbara A Fielding

18 Animal Models in Nutrition Research 265
Andrew M Salter

19 Cellular Models in Nutrition Research 278
Kathleen M Botham

20 Translation of Nutrition Research 307
Judith Buttriss

Glossary 326

Index 335

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