The only comprehensive guide to the clinical management of hematologic and lymphatic cancers Filling an unmet need in the clinical literature, this commanding, just-in-time reference sheds light on the full spectrum of cancers in the blood, bone marrow, and lymphatic system (leukemia, lymphoma, myeloma). Clinical Malignant Hematology is edited by staff members from the renowned Taussig Cancer Center at the Cleveland Clinic, which has pioneered some of the most important clinical discoveries and treatment trends in recent years. Look inside and you'll see a consistent, unified patient management strategy in each chapter, as well as a streamlined three-section format that expertly examines ontogeny and physiology of blood cells, myeloid neoplasia, and lymphoid neoplasia. You'll also find never-before-published perspectives and precise recommendations for dosing and other critical areas that reflect the latest scholarship of this increasingly vital field. Features Full coverage of all treatment modalities-chemotherapy, monoclonal antibodies, and hematopoietic stem cell transplantation Strong background chapters that offer guidance on how to address treatment complications and other supportive care issues A detailed, regimen-based orientation in each chapter Abundance of clinical pictures and photomicrographs displaying examples of peripheral blood smears and bone marrow aspirates Uniform headings and tables in each chapter, which convey specific recommendations on the work-up, staging, diagnosis, differential diagnosis, and treatment of hematologic malignancies Nearly 200 illustrations

Brian Bolwell, MD is Director, Department of Hematologic Malignancies and Bone Marrow Transplantation, Taussig Cancer Center, The Cleveland Clinic.

Matthew Kalacyio, MD is Director, Division of Leukemia, Taussig Cancer Center, The Cleveland Clinic.

Mikael Sekeres, MD, Associate Director, Division of Leukemia, Taussig Cancer Center, The Cleveland Clinic.

Table of Contents

Section 1-Ontogeny and Physiology of Blood Cells

1Production of Blood Cells

2Host Response to Infection/Ontogeny of Lymphoid Cells

Section 2Myeloid Neoplasia

3Chronic myeloid leukemia

4Myeloproliferative syndromesMyelofibrosis, Polycythemia Vera, Essential Thrombocythemia

5Hypereosinophilic syndromes

6Mast cell disease

7Chronic myelomonocytic leukemia

8Myelodysplastic syndromes

9Juvenile chronic myeloid leukemia

10Acute myeloid leukemia

11Acute myeloid leukemia with emphasis on stem cell transplantation therapy

12Treatment-related acute myeloid leukemia

13Acute promyelocytic leukemia

14Histiocytic disorders

Section 3Lymphoid Neoplasia

15Precursor B- and precursor T-lymphoblastic leukemia/lymphoma

16Chronic lymphocytic leukemia/small lymphocytic lymphoma

17B-cell prolymphocytic leukemia