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9780896033795

Thrombopoiesis and Thrombopoietins

by ; ; ;
  • ISBN13:

    9780896033795

  • ISBN10:

    0896033791

  • Format: Hardcover
  • Copyright: 1997-01-01
  • Publisher: Humana Pr Inc

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Supplemental Materials

What is included with this book?

Summary

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

Table of Contents

Foreword v(8)
Shirley Ebbe
Preface xiii(4)
List of Contributors xvii
PART I: INTRODUCTION 3(92)
1 Megakaryocyte Biology
3(38)
Carl W. Jackson
Julie T. Arnold
Tamara I. Pestina
Paula E. Stenberg
2 Platelet Structure and Function
41(22)
Dorothea Zucker-Franklin
3 The Evolution of Mammalian Platelets
63(16)
Jack Levin
4 Potential Clinical Applications of Thrombopoietic Growth Factors
79(16)
Charles A. Schiffer
PART II: THE SEARCH FOR THE PHYSIOLOGIC REGULATOR OF PLATELET PRODUCTION 95(86)
5 Historical Perspective and Overview
95(14)
Eric M. Mazur
6 The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl
109(14)
Francoise Wendling
Sylvie Gisselbrecht
7 Mpl Expression and Functional Role in Human Megakaryocytopoiesis
123(12)
Francoise Wendling
Najet Debili
William Vainchenker
8 The Purification and Cloning of Human Thrombopoietin
135(8)
Dan Eaton
9 The Purification of Thrombopoietin from Thrombocytopenic Plasma
143(22)
David J. Kuter
Hiroshi Miyazaki
Takashi Kato
10 The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis
165(16)
Ronald Hoffman
PART III: MOLECULAR BIOLOGY 181(36)
11 Structure of Thrombopoietin and the Thrombopoietin Gene
181(8)
Austin L. Gurney
Frederic J. de Sauvage
12 Transcription Factors in Megakaryocyte Differentiation and Gene Expression
189(14)
Ramesh A. Shivdasani
13 The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands
203(14)
Donald Foster
Pamela Hunt
PART IV: CELLULAR BIOLOGY 217(84)
14 In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells
217(20)
Najet Debili
Elisabeth Cramer
Francoise Wendling
William Vainchenker
15 Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis
237(20)
Dorothea Zucker-Franklin
16 The Thrombopoietin Receptor, Mpl, and Signal Transduction
257(14)
Kenneth Kaushansky
Virginia C. Broudy
Jonathan G. Drachman
17 Regulation of Proplatelet and Platelet Formation In Vitro
271(14)
Esther Choi
In Vitro Effects of Mpl Ligands on Platelet Function
285(16)
Laurence A. Harker
Ulla M. Marzec
Christopher F. Toombs
PART V: PRECLINICAL BIOLOGY 301(58)
19 In Vivo Dose-Response Effects of Mpl Ligands on Platelet Production and Function
301(20)
Laurence A. Harker
Christopher F. Toombs
Richard B. Stead
20 Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models
321(28)
Ann M. Farese
Thomas J. MacVittie
21 Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo
349(10)
Frederic J. de Sauvage
Mark W. Moore
PART VI: CLINICAL BIOLOGY 359(38)
22 Serum Levels of Thrombopoietin in Health and Disease
359(18)
Janet Lee Nichol
23 The Regulation of Platelet Production In Vivo
377(20)
David J. Kuter
Glossary 397(4)
Index 401

Supplemental Materials

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

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