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9781588291844

Biological Weapons Defense

by ; ; ; ;
  • ISBN13:

    9781588291844

  • ISBN10:

    1588291847

  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2005-01-01
  • Publisher: Humana Pr Inc

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Summary

Prominent experts in biodefense research-many from the US Army Medical Research Institute of Infectious Diseases-authoritatively delineate the universe of scientific, medical, and legal issues facing the biodefense research community. Regarding medical countermeasures and decontamination, the authors describe the treatment and pathogenesis of a variety of established pathogens (anthrax, plague, smallpox, Brucellosis, Glanders, and Coxiella burnettii) and review what is known about the aerosol route of infection and decontamination processes. They also examine how to discover the presence of these agents, or other previously unknown biological weapons, and detail the ongoing efforts to counter these agents, including proteomic and genomic analysis as a gateway to better diagnostics, therapeutics, vaccinations, genotyping, and forensics. Additional chapters discuss the development and use technology to identify and characterize these infectious organisms, emerging threats, and the development of countermeasures.

Table of Contents

Foreword
by David R. Franz, COL (RET.), DVM, PhD
v
Foreword
by Matthew Meselson, PhD
vii
Preface ix
Disclaimer xii
Contributors xvii
I. PREPARATION AND MILITARY SUPPORT FOR A POSSIBLE BIOTERRORISM INCIDENT
1 Department of Defense Capabilities Supporting Bioterrorism Response
Anna Johnson-Winegar, Karl Semancik, Robert S. Borowski, Keith R. Vesely, Brenda Wyler, Matt Eussen, and John V. Wade
3(20)
2 Modeling for Bioterrorism Incidents
Zygmunt F. Dembek
23(18)
3 Biological Weapons Defense: Effect Levels
Ross D. LeClaire and M. Louise M. Pitt
41(24)
II. MEDICAL COUNTERMEASURES AND DECONTAMINATION
4 Pathogenesis by Aerosol
M. Louise M. Pitt and Ross D. LeClaire
65(14)
5 Bacillus anthracis and the Pathogenesis of Anthrax
Dominique M. Missiakas and Olaf Schneewind
79(20)
6 Virologic and Pathogenic Aspects of the Variola Virus (Smallpox) as a Bioweapon
Robert G. Darling, Timothy H. Burgess, James V. Lawler, and Timothy P. Endy
99(22)
7 Plague Vaccines: Retrospective Analysis and Future Developments
Jeffrey J. Adamovicz and Gerard P. Andrews
121(34)
8 Medical Protection Against Brucellosis
David L. Hoover and Richard H. Borschel
155(30)
9 Pathogenesis of and Immunity to Coxiella burnetii
David M. Waag and Herbert A. Thompson
185(24)
10 Glanders: New Insights Into an Old Disease
David M. Waag and David DeShazer
209(30)
11 Medical Countermeasures for Filoviruses and Other Viral Agents
Alan Schmaljohn and Michael Hevey
239(16)
12 Medical Defense Against Protein Toxin Weapons: Review and Perspective
Charles B. Millard
255(30)
13 Antimicrobials for Biological Warfare Agents
Jon B. Woods
285(32)
14 Nonspecific Immunomodulator Therapy: CpG
D.G. Cerys Rees, Arthur M. Krieg, and Richard W. Titball
317(16)
15 Decontamination
Robert J. Hawley and Joseph P. Kozlovac
333(18)
III. EMERGING THREATS AND FUTURE PREPARATION
16 Definition and Overview of Emerging Threats
Luther E. Lindler, Eileen Choffnes, and George W. Korch
351(10)
17 Department of Defense Global Emerging Infections System Programs in Biodefense
Julie A. Pavlin and Patrick W. Kelley
361(26)
18 Information Resources and Database Development for Defense Against Biological Weapons
Frank J. Lebeda, Murray Wolinsky, and Elliot J. Lefkowitz
387(30)
19 Genomic Efforts With Biodefense Pathogens
Rekha Seshadri, Timothy D. Read, William C. Merman, and Ian T. Paulsen
417(18)
20 Genomics for Biodefense: Exploiting the Francisella tularensis Genome Sequence
Siv G.E. Andersson, Mats Forsman, Petra C.F. Oyston, and Richard W. Titball
435(18)
21 Genetic Fingerprinting of Biodefense Pathogens for Epidemiology and Forensic Investigation
Luther E. Lindler, Xiao-Zhe Huang, May Chu, Ted L. Hadfield, and Michael Dobson
453(28)
22 Yersinia pestis as an Emerged Pathogen: What Lessons Can Be Learned?
Luther E. Lindler
481(28)
IV. DIAGNOSTIC DEVELOPMENT FOR BIOWARFARE AGENTS
23 Requirements for Biological Threat Identification Systems
Erik A. Henchal and George V. Ludwig
509(16)
24 DNA-Based Diagnostic Tests for Detection and Identification of Biological Weapons
Luther E. Lindler, David Norwood, Michael Dobson, and Ted L. Hadfield
525(26)
25 Concepts for the Development of Immunodiagnostic Assays for Detection and Diagnosis of Biothreat Agents
George V. Ludwig, Cynthia A. Rossi, and Robert L. Bull
551(30)
Index 581

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