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9781555814083

Pneumococcal Vaccines

by ; ;
  • ISBN13:

    9781555814083

  • ISBN10:

    1555814085

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-02-28
  • Publisher: Amer Society for Microbiology

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Summary

Summarizes latest findings on the effects of pneumococcal conjugate vaccine. Includes chapters on epidemiology, immunologic mechanisms, conjugation methods, antibiotic resistance, and PCV immunogenicity in health and high-risk individuals. For practitioners and public health professionals. DNLM: Pneumococcal Vaccines--immunology.

Table of Contents

Dedication: Robert Austrian
History
The History of Pneumococcal Diseasep. 3
History of Pneumococcal Immunizationp. 19
Biological Basis
Genetics, Biosynthesis, and Chemistry of Pneumococcal Capsular Polysaccharidesp. 33
Animal Models of Invasive Pneumococcal Diseasep. 47
Animal Models of Pneumococcal Colonizationp. 59
The Immunobiology of Polysaccharide and Conjugate Vaccinesp. 67
Interactions of Streptococcus pneumoniae with Complement Proteinsp. 83
Clinical Disease and Epidemiology
Epidemiology, Diagnosis, and Treatment of Serious Pneumococcal Infections in Childrenp. 95
Pneumococcal Pneumonia in Adults: Epidemiology, Clinical Features, Diagnosis, and Therapyp. 117
Pneumococcal Serotype Epidemiologyp. 139
Manufacturing and Product Release Issues
Conjugation Chemistryp. 163
Pneumococcal Vaccines: Manufacture and Quality Control for Product Releasep. 175
Licensing of Pneumococcal Conjugate Vaccines for Children and Adults: Regulatory Perspective from the European Medicines Agency and the U.S. Food and Drug Administrationp. 183
Immunogenicity
Quantitation of Anti-Pneumococcal Capsular Antibody in Ligand-Binding Assaysp. 199
Functional Assays for Pneumococcal Antibodyp. 213
Immunogenicity and Reactogenicity of Pneumococcal Conjugate Vaccines in Infants and Childrenp. 227
Immunogenicity and Safety in Adultsp. 245
Immunogenicity in High-Risk and Immunocompromised Children and Adultsp. 261
Efficacy and Safety
Nasopharyngeal Carriagep. 279
Acute Otitis Media and Its Sequelaep. 301
Meta-Analysis of the Efficacy of Conjugate Vaccines against Invasive Pneumococcal Diseasep. 317
Efficacy and Safety of Conjugate Pneumococcal Vaccine in the Prevention of Pneumoniap. 327
Establishing Immune Correlates of Protectionp. 339
Public Health Impact
Direct and Indirect Effectiveness and Safety of Pneumococcal Conjugate Vaccine in Practicep. 353
Impact of Conjugate Pneumococcal Vaccine on Antibiotic Resistancep. 369
Pharmacoeconomics of Pneumococcal Conjugate Vaccinesp. 387
Opportunities and Challenges for Pneumococcal Conjugate Vaccines in Low- and Middle-Income Countriesp. 405
Where Next
Protein Vaccinesp. 421
Conclusionsp. 437
Indexp. 441
Table of Contents provided by Blackwell. All Rights Reserved.

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