An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Acknowledgments

v

Preface

vii

Contributors

xiii

Value-Added eBook/PDA

xvii

PART I: BASIC SCIENCE OF TUMOR ANTIGENS AND IMMUNE ACTIVATION

1 Biology of the Cancer Vaccine Immune Response

3

(8)

Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly

2 The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity

11

(8)

John Fikes

3 Identification of Tumor Antigens Using Subtraction and Microarrays

19

(12)

Jiangchun Xu

4 Tumor Antigen Discovery With T Cells

31

(18)

Paul F. Robbins

5 Targeting Viral Antigens for the Treatment of Malignancies

49

(16)

Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau, Michael I. Nishimura, and W. Martin Kast

6 Immune Defects in Cancer

65

(20)

Dmitry Gabrilovich and Vladimir Pisarev

7 Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-s-Signaling Pathway

85

(14)

Gerard C. Blobe

PART II: GENERAL VACCINE AND IMMUNOTHERAPY STRATEGIES

8 Immune Adjuvants

99

(16)

Jory R. Baldridge, Susan Hand Zimmermann, and Sally P. Mossman

9 Heterologous Prime-Boost Vaccination in Tumor Immunotherapy

115

(6)

Michael J. Palmowski and Caroline Smith

10 Peptide-Based Vaccines

121

(16)

Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, Kathy Schiffman, and Mary L. Disis

11 Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens

137

(20)

Govind Ragupathi, John Gathuru, and Philip O. Livingston

12 Anti-Idiotype Vaccines

157

(18)

Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, and Kenneth A. Foon

13 Pox Viral Vaccines

175

(18)

James L. Gulley, Philip M. Arlen, and Jeffrey Schlom

14 Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches

193

(10)

Zachary Hartman and Andrea Amalfitano

15 Alphaviral-Based Strategies for the Immunotherapy of Cancer

203

(22)

Edward L. Nelson and Jonathan Smith

16 DNA Vaccines

225

(24)

Michael Bereta and Howard L. Kaufman

17 Whole-Cell Vaccines

249

(4)

Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, and Michael A. Morse

18 Gene-Modified Tumor-Cell Vaccines

253

(22)

Leisha A. Enrens and Elizabeth M. Jaffee

19 Hapten-Modified Tumor Vaccines

275

(22)

David Berd

20 Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines

297

(20)

Michael W. Graner and Emmanuel Katsanis

21 Dendritic Cell Vaccines

317

(14)

Madhav V. Dhodapkar

22 Exosomes for Immunotherapy of Cancer

331

(10)

Nathalie Chaput, N.E.C. Schartz, Fabrice Andre, and Laurence Zitvogel

23 Immunocytokines for Cancer Immunotherapy

341

(18)

Paul M. Sondel and Steven D. Gillies

24 T-Cell Adoptive Immunotherapy

359

(20)

Gregory E. Plautz, Peter A. Cohen, David E. Weng, and Suyu Shu

PART III: TUMOR-SPECIFIC VACCINE DEVELOPMENT

25 Melanoma Vaccines

379

(18)

Jeffrey Weber

26 Allogenic Melanoma Lysate Vaccines

397

(18)

Malcolm S. Mitchell

27 Renal Cancer Vaccines

415

(10)

Hyung L. Kim, Barbara J. Gitlitz, and Robert A. Figlin

28 Vaccines for Hematological Malignancies

425

(26)

Qing Vi

29 Vaccines for the Immunotherapy of Prostate Cancer

451

(14)

Boris Minev and Michael L. Salgaller

30 Vaccine Therapy for Breast and Ovarian Cancers

465

(26)

Susan E. Smith and Alison T. Stopeck

31 Vaccine Therapy for Gastrointestinal Cancers

491

(14)

John L. Marshall

32 Vaccines for Lung Cancer

505

(8)

Michael A. Morse, Jennifer Garst, and Eric Toloza

33 Vaccines for Other Tumors

513

(6)

Michael A. Morse

PART IV: CLINICAL TRIALS AND IMMUNE ANALYSES

34 Clinical Trial Designs for Therapeutic Vaccine Studies

519

(8)

Richard Simon

35 Analysis of Cellular Immune Responses In Cancer Vaccine Trials

527

(16)

Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, and H. Kim Lyerly

36 Analysis of Humoral Immune Responses in Vaccine Trials

543

(20)

Rajasekharan Somasundaram, Tiangian Zhang, and Dorothee Herlyn

37 Regulatory Issues Affecting Tumor Vaccines

563

(14)

Mark O. Thornton, Alexandra S. Worobec, Keith Wonnacott, and Raj K. Purl

Index

577

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Handbook of Cancer Vaccines

9781588292094

1588292096

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