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9781586030926

Vascular Endothelium: Source and Target of Inflammatory Mediators

by
  • ISBN13:

    9781586030926

  • ISBN10:

    1586030922

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2002-01-01
  • Publisher: IOS PRESS INC

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Summary

This is the seventh in a series of monographs on aspects of endothelial cell biology. All are derived from the proceedings of similarly titled NATO-sponsored Advanced Study Institutes. The book includes chapters on the clinical profile of important vascular diseases, such as pulmonary hypertension, atherosclerosis and stroke, as well as chapters in various underlying biological mechanisms. Present are in depth discussions on the role of endothelins, type 1, 2 and 3 nitric oxide synthases, guanyl cyclases, cadherins, pentraxins, various transcriptions factors regulating relevant gene activations, intracellular signaling molecules, thrombin and complement. Also discussed are regulatory processes, including apoptosis, hyperlipidemia and hyperglycemia, endothelial cell permeability, microvascular architecture, as well as exciting new advances in the management of atherosclerosis and stroke.

Table of Contents

Preface
List of Participants
Establishing Endothelial Function in the Immature Pulmonary Vasculature, Normal and Hypertensivep. 1
Vascular Actions of Endothelinp. 19
An Immunotherapeutic Approach for the Treatment of Low Plasma HDL-Cholesterolp. 26
Endothelial Dysfunction and Atherosclerosisp. 34
Transcriptional Regulation of Pro- and Anti-Atherogenic Genesp. 42
Effect of Hyperlipemia and Hyperglycemia on the Vascular Endotheliump. 87
New Endothelium-Based Approaches to Stroke Therapyp. 100
Adhesive Structures in Vascular Endothelial Cellsp. 108
Atheroprotective Mechanisms of Fluid Shear Stress: Nitric Oxide Independent Inhibition of Signal Transduction Mediated by Inflammatory Cytokinesp. 115
IL-1/Toll Receptors and Long Pentraxins in Endothelial Cellsp. 126
Mechanisms Involved in Endothelial Hyperpermeability and Endothelial Barrier Stabilizationp. 135
3D-Morphometry of the Microvascular Unit in Tumors and Normal Tissues: Quantitative Studies on Microvascular Corrosion Castsp. 151
Pathophysiological Consequences of Complement-Endothelial Cell Interactionp. 166
Expressional Regulation and Subcellular Localization of the Nitric Oxide Receptor Soluble Guanylyl Cyclase (sGC)p. 177
Regulation of Vascular Nitric Oxide Synthase IIp. 188
Oral Communicationsp. 211
Postersp. 343
Author Indexp. 397
Table of Contents provided by Blackwell. All Rights Reserved.

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