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9781588297419

Prostate Cancer

by ; ;
  • ISBN13:

    9781588297419

  • ISBN10:

    1588297411

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-03-30
  • Publisher: Humana Pr Inc

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Summary

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. The authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer and into future, novel treatment strategies.

Table of Contents

Histopathology and Molecular Biology of Prostate Atrophy: A Lesion Associated with Inflammation, Prostate Intraepithelial Neoplasia, and Prostate Cancerp. 1
Epigenetic Gene Silencing in Prostate Cancerp. 17
Inherited Genetic Changes in Prostate Cancerp. 53
Prostate Molecular Oncogenesis: Gene Deletions and Somatic Mutationsp. 71
Somatic Genetic Changes in Prostate Cancer: Androgen Receptor Alterationsp. 99
Androgen Receptor in Prostate Cancer Progressionp. 129
Epigenetic Modification and Acetylation of Androgen Receptor Regulate Prostate Cellular Growthp. 147
Estrogen Receptor [alpha] and [beta] in the Regulation of Normal and Malignant Prostate Epitheliump. 163
Estrogen Action in Normal Prostate Epithelium and in Prostate Cancerp. 181
Hypoxia-Inducible Factor 1 in the Angiogenesis of Prostate Cancerp. 209
Signal Transduction by the Ras-MAP Kinase Pathway in Prostate Cancer Progressionp. 223
Transcription Factors STAT5 and STAT3: Survival Factors for Prostate Cancer Cellsp. 257
Role of PI3K-Akt and PTEN in the Growth and Progression of Prostate Cancerp. 291
New Perspectives in Prediction of Clinical Outcome of Prostate Cancer: TMPRSS2-ETS Gene Fusion in Prostate Cancerp. 309
New Directions in Radiation Therapy of Prostate Cancer: Brachytherapy and Intensity-Modulated Radiation Therapyp. 323
The Current Knowledge of Hormonal Therapy in the Treatment of Prostate Cancerp. 339
Advances in Surgical Intervention of Prostate Cancer: Comparison of the Benefits and Pitfalls of Retropubic, Perineal, and Laparoscopic Radical Prostatectomyp. 355
Targeted Therapy Trials for Prostate Cancerp. 383
New Perspectives on Chemotherapy in Prostate Cancerp. 401
Concluding Remarks: The Future of Prostate Cancerp. 427
Indexp. 439
Table of Contents provided by Blackwell. All Rights Reserved.

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